Search Results - "Navalkar, Ambuja"

α-Synuclein aggregation nucleates through liquid–liquid phase separation by Ray, Soumik, Singh, Nitu, Kumar, Rakesh, Patel, Komal, Pandey, Satyaprakash, Datta, Debalina, Mahato, Jaladhar, Panigrahi, Rajlaxmi, Navalkar, Ambuja, Mehra, Surabhi, Gadhe, Laxmikant, Chatterjee, Debdeep, Sawner, Ajay Singh, Maiti, Siddhartha, Bhatia, Sandhya, Gerez, Juan Atilio, Chowdhury, Arindam, Kumar, Ashutosh, Padinhateeri, Ranjith, Riek, Roland, Krishnamoorthy, G., Maji, Samir K.

“…α-Synuclein (α-Syn) aggregation and amyloid formation is directly linked with Parkinson’s disease pathogenesis. However, the early events involved in this…”
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Intermolecular interactions underlie protein/peptide phase separation irrespective of sequence and structure at crowded milieu by Poudyal, Manisha, Patel, Komal, Gadhe, Laxmikant, Sawner, Ajay Singh, Kadu, Pradeep, Datta, Debalina, Mukherjee, Semanti, Ray, Soumik, Navalkar, Ambuja, Maiti, Siddhartha, Chatterjee, Debdeep, Devi, Jyoti, Bera, Riya, Gahlot, Nitisha, Joseph, Jennifer, Padinhateeri, Ranjith, Maji, Samir K.

“…Liquid-liquid phase separation (LLPS) has emerged as a crucial biological phenomenon underlying the sequestration of macromolecules (such as proteins and…”
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Direct evidence of cellular transformation by prion-like p53 amyloid infection by Navalkar, Ambuja, Pandey, Satyaprakash, Singh, Namrata, Patel, Komal, Datta, Debalina, Mohanty, Bhabani, Jadhav, Sachin, Chaudhari, Pradip, Maji, Samir K

“…Tumor suppressor p53 mutations are associated with more than 50% of cancers. Aggregation and amyloid formation of p53 is also implicated in cancer…”
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p53 amyloid formation leading to its loss of function: implications in cancer pathogenesis by Ghosh, Saikat, Salot, Shimul, Sengupta, Shinjinee, Navalkar, Ambuja, Ghosh, Dhiman, Jacob, Reeba, Das, Subhadeep, Kumar, Rakesh, Jha, Narendra Nath, Sahay, Shruti, Mehra, Surabhi, Mohite, Ganesh M, Ghosh, Santanu K, Kombrabail, Mamata, Krishnamoorthy, Guruswamy, Chaudhari, Pradip, Maji, Samir K

“…The transcriptional regulator p53 has an essential role in tumor suppression. Almost 50% of human cancers are associated with the loss of p53 functions, where…”
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Fabrication of Silver Nanowire/Polydimethylsiloxane Dry Electrodes by a Vacuum Filtration Method for Electrophysiological Signal Monitoring by Kisannagar, Ravinder Reddy, Jha, Pallavi, Navalkar, Ambuja, Maji, Samir K, Gupta, Dipti

“…Flexible and dry electrodes have attracted huge attention due to their potential application in long-term electrophysiological signal monitoring. In this work,…”
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Co-aggregation and secondary nucleation in the life cycle of human prolactin/galanin functional amyloids by Chatterjee, Debdeep, Jacob, Reeba S, Ray, Soumik, Navalkar, Ambuja, Singh, Namrata, Sengupta, Shinjinee, Gadhe, Laxmikant, Kadu, Pradeep, Datta, Debalina, Paul, Ajoy, Arunima, Sakunthala, Mehra, Surabhi, Pindi, Chinmai, Kumar, Santosh, Singru, Praful, Senapati, Sanjib, Maji, Samir K

“…Synergistic-aggregation and cross-seeding by two different proteins/peptides in the amyloid aggregation are well evident in various neurological disorders…”
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Cyclic Organoselenide BODIPY-Based Probe: Targeting Superoxide in MCF-7 Cancer Cells by Madibone, Kashinath S, Deshmukh, Pratiksha P, Navalkar, Ambuja, Maji, Samir K, Badani, Purav M, Manjare, Sudesh T

“…All aerobic cells contain reactive oxygen species (ROSs) in balance with biochemical antioxidants. Oxidative stress is developed when this balance gets…”
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First person – Ambuja Navalkar

“…ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career…”
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First person – Ambuja Navalkar

“…ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career…”
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Prion-like p53 Amyloids in Cancer by Navalkar, Ambuja, Ghosh, Saikat, Pandey, Satyaprakash, Paul, Ajoy, Datta, Debalina, Maji, Samir K

“…The global transcription factor, p53, is a master regulator of gene expression in cells. Mutations in the TP53 gene promote unregulated cell growth through the…”
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Amyloid fibril-based thixotropic hydrogels for modeling of tumor spheroids in vitro by Singh, Namrata, Patel, Komal, Navalkar, Ambuja, Kadu, Pradeep, Datta, Debalina, Chatterjee, Debdeep, Mukherjee, Semanti, Shaw, Ranjit, Gahlot, Nitisha, Shaw, Abhishek, Jadhav, Sachin, Maji, Samir K.

“…Biomaterials mimicking extracellular matrices (ECM) for three-dimensional (3D) cultures have gained immense interest in tumor modeling and in vitro organ…”
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Phenylselenyl containing turn-on dibodipy probe for selective detection of superoxide in mammalian breast cancer cell line by Deshmukh, Pratiksha P., Navalkar, Ambuja, Maji, Samir K., Manjare, Sudesh T.

“…[Display omitted] •New selenium containing diBODIPY-based probe was synthesized for selective and sensitive detection of superoxide.•Phenyl selenide group in…”
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Organoselenium-based BOPHY as a sensor for detection of hypochlorous acid in mammalian cells by Malankar, Gauri S., Sakunthala, Arunima, Navalkar, Ambuja, Maji, Samir K., Raju, Saravanan, Manjare, Sudesh T.

“…Phenylselenide substituted BOPHY probes (BOPHY-SePh and PhSe-BOPHY-SePh) were synthesized and characterized by NMR spectroscopy and single-crystal XRD. Both…”
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MYC phase separation selectively modulates the transcriptome by Yang, Junjiao, Chung, Chan-I, Koach, Jessica, Liu, Hongjiang, Navalkar, Ambuja, He, Hao, Ma, Zhimin, Zhao, Qian, Yang, Xiaoyu, He, Liang, Mittag, Tanja, Shen, Yin, Weiss, William A., Shu, Xiaokun

“…Dysregulation and enhanced expression of MYC transcription factors (TFs) including MYC and MYCN contribute to the majority of human cancers. For example, MYCN…”
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Author Correction: MYC phase separation selectively modulates the transcriptome by Yang, Junjiao, Chung, Chan-I, Koach, Jessica, Liu, Hongjiang, Navalkar, Ambuja, He, Hao, Ma, Zhimin, Zhao, Qian, Yang, Xiaoyu, He, Liang, Mittag, Tanja, Shen, Yin, Weiss, William A., Shu, Xiaokun

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Oncogenic gain of function due to p53 amyloids occurs through aberrant alteration of cell cycle and proliferation by Navalkar, Ambuja, Paul, Ajoy, Sakunthala, Arunima, Pandey, Satyaprakash, Dey, Amit Kumar, Saha, Sandhini, Sahoo, Sarthak, Jolly, Mohit Kumar, Maiti, Tushar K., Maji, Samir K.

“…ABSTRACT Transcription factor p53 (also known as TP53) has been shown to aggregate into cytoplasmic and nuclear inclusions, compromising its native tumor…”
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Comparison of Kinetics, Toxicity, Oligomer Formation, and Membrane Binding Capacity of α‑Synuclein Familial Mutations at the A53 Site, Including the Newly Discovered A53V Mutation by Mohite, Ganesh M, Kumar, Rakesh, Panigrahi, Rajlaxmi, Navalkar, Ambuja, Singh, Nitu, Datta, Debalina, Mehra, Surabhi, Ray, Soumik, Gadhe, Laxmikant G, Das, Subhadeep, Singh, Namrata, Chatterjee, Debdeep, Kumar, Ashutosh, Maji, Samir K

“…The involvement of α-synuclein (α-Syn) amyloid formation in Parkinson’s disease (PD) pathogenesis is supported by the discovery of α-Syn gene (SNCA) mutations…”
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Direct Demonstration of Seed Size-Dependent α‑Synuclein Amyloid Amplification by Sakunthala, Arunima, Datta, Debalina, Navalkar, Ambuja, Gadhe, Laxmikant, Kadu, Pradeep, Patel, Komal, Mehra, Surabhi, Kumar, Rakesh, Chatterjee, Debdeep, Devi, Jyoti, Sengupta, Kundan, Padinhateeri, Ranjith, Maji, Samir K.

“…The size of amyloid seeds is known to modulate their autocatalytic amplification and cellular toxicity. However, the seed size-dependent secondary nucleation…”
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Lipopolysaccharide from Gut Microbiota Modulates α‑Synuclein Aggregation and Alters Its Biological Function by Bhattacharyya, Dipita, Mohite, Ganesh M, Krishnamoorthy, Janarthanan, Gayen, Nilanjan, Mehra, Surabhi, Navalkar, Ambuja, Kotler, Samuel A, Ratha, Bhisma N, Ghosh, Anirban, Kumar, Rakesh, Garai, Kanchan, Mandal, Atin K, Maji, Samir K, Bhunia, Anirban

“…Altered intestinal permeability has been correlated with Parkinson’s pathophysiology in the enteric nervous system, before manifestations in the central…”
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An efficient chemodosimeter for the detection of Hg(II) via diselenide oxidation by Deshmukh, Pratiksha P, Malankar, Gauri S, Sakunthala, Arunima, Navalkar, Ambuja, Maji, Samir K, Murale, Dhiraj P, Saravanan, Raju, Manjare, Sudesh T

“…Mercury ions are toxic and exhibit hazardous effects on the environment and biological systems, and thus demand for the selective and sensitive detection of…”
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