Search Results - "Navai, Shoba"

CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression by Fousek, Kristen, Watanabe, Junji, Joseph, Sujith K., George, Ann, An, Xingyue, Byrd, Tiara T., Morris, Jessica S., Luong, Annie, Martínez-Paniagua, Melisa A., Sanber, Khaled, Navai, Shoba A., Gad, Ahmed Z., Salsman, Vita S., Mathew, Pretty R., Kim, Hye Na, Wagner, Dimitrios L., Brunetti, Lorenzo, Jang, Albert, Baker, Matthew L., Varadarajan, Navin, Hegde, Meenakshi, Kim, Yong-Mi, Heisterkamp, Nora, Abdel-Azim, Hisham, Ahmed, Nabil

“…Chimeric antigen receptor (CAR) T-cells targeting CD19 demonstrate remarkable efficacy in treating B-lineage acute lymphoblastic leukemia (BL-ALL), yet up to…”
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Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma by Hegde, Meenakshi, Joseph, Sujith K., Pashankar, Farzana, DeRenzo, Christopher, Sanber, Khaled, Navai, Shoba, Byrd, Tiara T., Hicks, John, Xu, Mina L., Gerken, Claudia, Kalra, Mamta, Robertson, Catherine, Zhang, Huimin, Shree, Ankita, Mehta, Birju, Dakhova, Olga, Salsman, Vita S., Grilley, Bambi, Gee, Adrian, Dotti, Gianpietro, Heslop, Helen E., Brenner, Malcolm K., Wels, Winfried S., Gottschalk, Stephen, Ahmed, Nabil

“…Refractory metastatic rhabdomyosarcoma is largely incurable. Here we analyze the response of a child with refractory bone marrow metastatic rhabdomyosarcoma to…”
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Tandem CAR T cells targeting HER2 and IL13R alpha 2 mitigate tumor antigen escape by Hegde, Meenakshi, Mukherjee, Malini, Grada, Zakaria, Pignata, Antonella, Landi, Daniel, Navai, Shoba A, Wakefield, Amanda, Fousek, Kristen, Bielamowicz, Kevin, Chow, Kevin K H, Brawley, Vita S, Byrd, Tiara T, Krebs, Simone, Gottschalk, Stephen, Wels, Winfried S, Baker, Matthew L, Dotti, Gianpietro, Mamonkin, Maksim, Brenner, Malcolm K, Orange, Jordan S, Ahmed, Nabil

“…In preclinical models of glioblastoma, antigen escape variants can lead to tumor recurrence after treatment with CAR T cells that are redirected to single…”
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Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape by Hegde, Meenakshi, Mukherjee, Malini, Grada, Zakaria, Pignata, Antonella, Landi, Daniel, Navai, Shoba A, Wakefield, Amanda, Fousek, Kristen, Bielamowicz, Kevin, Chow, Kevin K H, Brawley, Vita S, Byrd, Tiara T, Krebs, Simone, Gottschalk, Stephen, Wels, Winfried S, Baker, Matthew L, Dotti, Gianpietro, Mamonkin, Maksim, Brenner, Malcolm K, Orange, Jordan S, Ahmed, Nabil

“…In preclinical models of glioblastoma, antigen escape variants can lead to tumor recurrence after treatment with CAR T cells that are redirected to single…”
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Targeting the tumour profile using broad spectrum chimaeric antigen receptor T-cells by Navai, Shoba A, Ahmed, Nabil

“…A variety of distinct and redundant mechanisms support tumour propagation and survival. Tumour parenchyma consists of a variety of geographically diverse cells…”
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Pediatric liposarcoma: A case series and literature review by Baday, Yiressy Izaguirre, Navai, Shoba A., Hicks, M. John, Venkatramani, Rajkumar, Whittle, Sarah B.

“…Liposarcoma is arare soft tissue sarcoma in children. While prognosis, clinical behavior, and response to therapy among the various histologic subtypes are…”
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Malignant melanoma incidence among children and adolescents in Texas and SEER 13, 1995–2013 by Danysh, Heather E., Navai, Shoba A., Scheurer, Michael E., Hunt, Raegan, Venkatramani, Rajkumar

“…Background Epidemiological knowledge and predictors of melanoma among children and adolescents in multiethnic populations are limited. Procedure Using data…”
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Severe COVID‐19 infection in a child receiving immunotherapy for cancer by Smith, Valeria R., Whittle, Sarah B., Coleman, Ryan D., Munoz, Flor M., De Guzman, Marietta M., Foster, Jennifer H., Navai, Shoba A.

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Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape by Hegde, Meenakshi, Mukherjee, Malini, Grada, Zakaria, Pignata, Antonella, Landi, Daniel, Navai, Shoba A, Wakefield, Amanda, Fousek, Kristen, Bielamowicz, Kevin, Chow, Kevin Kh, Brawley, Vita S, Byrd, Tiara T, Krebs, Simone, Gottschalk, Stephen, Wels, Winfried S, Baker, Matthew L, Dotti, Gianpietro, Mamonkin, Maksim, Brenner, Malcolm K, Orange, Jordan S, Ahmed, Nabil

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Incidence and predictors of treatment‐related conjugated hyperbilirubinemia during early treatment phases for children with acute lymphoblastic leukemia by Hashmi, Saman K., Navai, Shoba A., Chambers, Tiffany M., Scheurer, Michael E., Hicks, M. John, Rau, Rachel E., Gramatges, Maria M.

“…Conjugated hyperbilirubinemia (CHB) and liver transaminase elevation are known complications of acute lymphoblastic leukemia (ALL) therapy, but host risk…”
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Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape by Hegde, Meenakshi, Mukherjee, Malini, Grada, Zakaria, Pignata, Antonella, Landi, Daniel, Navai, Shoba A, Wakefield, Amanda, Fousek, Kristen, Bielamowicz, Kevin, Chow, Kevin Kh, Brawley, Vita S, Byrd, Tiara T, Krebs, Simone, Gottschalk, Stephen, Wels, Winfried S, Baker, Matthew L, Dotti, Gianpietro, Mamonkin, Maksim, Brenner, Malcolm K, Orange, Jordan S, Ahmed, Nabil

“…Expression of Concern Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells Motoshi Suzuki, Ke Cao, Seiichi Kato, Yuji…”
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Advancing the Care of Pediatric Rare Solid Tumors: A virtual rare tumor board by Mahajan, Priya, Navai, Shoba, Smith, Valeria, Potter, Samara, Venkatramani, Rajkumar

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803: CARDIOTOXICITY OF IMMUNE EFFECTOR CELLULAR THERAPIES IN PEDIATRIC HEMATOLOGIC AND SOLID TUMORS by Ross, Aaron, Puri, Kriti, Rainusso, Nino, Morales, erin, Navai, Shoba, Ahmed, Nabil, Hegde, Meenakshi, Omer, Bilal, Heczey, Andras, Salem, Baheyeldin, Steffin, David, Heslop, Helen, Bhar, Saleh

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Abstract 6605: Functional screening of bispecific CAR ectodomains targeting HER2 and GD2 in melanoma by Joseph, Sujith K., Navai, Shoba A., Grada, Zakaria, Fousek, Kristen, Mathew, Pretty R., Shree, Ankita, Wakefield, Amanda, Ahmed, Nabil, Hegde, Meenakshi

“…Abstract We describe the development of targeted immunotherapy using a bispecific chimeric antigen receptor (CAR) modified T-cell directed against the tumor…”
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Prolonged cytopenias after immune effector cell therapy and lymphodepletion in patients with leukemia, lymphoma and solid tumors by Miller, Anne, Daum, Rachel, Wang, Tao, Wu, Mengfen, Tat, Candise, Pfeiffer, Thomas, Navai, Shoba, Heczey, Andras, Hegde, Meenakshi, Ahmed, Nabil, Whittle, Sarah B., Hill, LaQuisa, Martinez, Caridad, Krance, Robert, Ramos, Carlos A., Rouce, Rayne H., Lulla, Premal, Heslop, Helen E., Omer, Bilal, Shekar, Meghan

“…The success of chimeric antigen receptor (CAR) T-cell therapy in treating B-cell malignancies has led to the evaluation of CAR T-cells targeting a variety of…”
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Tandem CAR T cells targeting HER2 and IL13Ra2 mitigate tumor antigen escape by Hegde, Meenakshi, Mukherjee, Malini, Grada, Zakaria, Pignata, Antonella, Landi, Daniel, Navai, Shoba A, Wakefield, Amanda, Fousek, Kristen, Bielamowicz, Kevin, Chow, Kevin K.H, Brawley, Vita S, Byrd, Tiara T, Krebs, Simone, Gottschalk, Stephen, Wels, Winfried S, Baker, Matthew L, Dotti, Gianpietro, Mamonkin, Maksim, Brenner, Malcolm K, Orange, Jordan S, Ahmed, Nabil

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Abstract LB-147: Administration of HER2-CAR T cells after lymphodepletion safely improves T cell expansion and induces clinical responses in patients with advanced sarcomas by Navai, Shoba A., Derenzo, Christopher, Joseph, Sujith, Sanber, Khaled, Byrd, Tiara, Zhang, Huimin, Mata, Melinda, Gerken, Claudia, Shree, Ankita, Mathew, Pretty R., Dakhova, Olga, Salsman, Vita, Hicks, John, Yi, Zhongzhen, Wu, Meng-Fen, Wang, Tao, Grilley, Bambi, Rooney, Cliona, Brenner, Malcom, Heslop, Helen, Gee, Adrian, Gottschalk, Stephen, Ahmed, Nabil, Hegde, Meenakshi

“…Abstract Background: Patients with advanced sarcoma have limited treatment options and poor survival. In our phase 1 dose-escalation trial, intravenous…”
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Targeting Primary Pre-B Cell Acute Lymphoblastic Leukemia and CD19-Negative Relapses Using Trivalent CAR T Cells by Fousek, Kristen, Watanabe, Junji, George, Ann, An, Xingyue, Samaha, Hebatalla, Navai, Shoba Alaska, Byrd, Tiara T, Jang, Albert, Kim, Hye Na, Joseph, Sujith, Baker, Matthew, Varadarajan, Navin, Hegde, Meenakshi G., Kim, Yong-Mi, Heisterkamp, Nora, Abdel-Azim, Hisham, Ahmed, Nabil

“…B-Acute Lymphoblastic Leukemia (B-ALL) is the most common malignancy in children, and limited treatment options exist for patients with relapsed or refractory…”
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392. Super-Resolution (STED) Imaging Reveals Simultaneous Co-Docking of Tandem Chimeric Antigen Receptors to Two Target Antigens Enhancing T Cell Functionality and Mitigating Antigen Escape by Mukherjee, Malini, Navai, Shoba, Landi, Daniel, Fousek, Kristen, Pignata, Antonella, Bielamowicz, Kevin, Byrd, Tiara, Mamonkin, Maksim, Hegde, Meenakshi, Brenner, Malcolm K., Orange, Jordan S., Ahmed, Nabil

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Targeting CD19-negative relapsed B-acute lymphoblastic leukemia using trivalent CAR T cells by Fousek, Kristen, Watanabe, Junji, George, Ann, An, Xingyue, Samaha, Heba Samir, Navai, Shoba Alaska, Byrd, Tiara T, Jang, Albert, Kim, Hye Na, Joseph, Sujith, Baker, Matthew, Varadarajan, Navin, Hegde, Meenakshi G., Kim, Yong-Mi, Heisterkamp, Nora, Abdel-Azim, Hisham M., Ahmed, Nabil M.

“…Abstract only 121 Background: Chimeric antigen receptor (CAR) T cells targeting CD19 have shown remarkable efficacy in treating relapsed B cell acute…”
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