Search Results - "Nava Zaarur"

Sortilin and retromer mediate retrograde transport of Glut4 in 3T3-L1 adipocytes by Pan, Xiang, Zaarur, Nava, Singh, Maneet, Morin, Peter, Kandror, Konstantin V

“…Sortilin is a multiligand sorting receptor responsible for the anterograde transport of lysosomal enzymes and substrates. Here we demonstrate that sortilin is…”
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Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue by Liu-Yesucevitz, Liqun, Bilgutay, Aylin, Zhang, Yong-Jie, Vanderweyde, Tara, Vanderwyde, Tara, Citro, Allison, Mehta, Tapan, Zaarur, Nava, McKee, Ann, Bowser, Robert, Sherman, Michael, Petrucelli, Leonard, Wolozin, Benjamin

“…Tar DNA Binding Protein-43 (TDP-43) is a principle component of inclusions in many cases of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral…”
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Proteasome Failure Promotes Positioning of Lysosomes around the Aggresome via Local Block of Microtubule-Dependent Transport by Zaarur, Nava, Meriin, Anatoli B., Bejarano, Eloy, Xu, Xiaobin, Gabai, Vladimir L., Cuervo, Ana Maria, Sherman, Michael Y.

“…Ubiquitinated proteins aggregate upon proteasome failure, and the aggregates are transported to the aggresome. In aggresomes, protein aggregates are actively…”
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ATGL-1 mediates the effect of dietary restriction and the insulin/IGF-1 signaling pathway on longevity in C. elegans by Zaarur, Nava, Desevin, Kathleen, Mackenzie, James, Lord, Avery, Grishok, Alla, Kandror, Konstantin V.

“…Animal lifespan is controlled through genetic pathways that are conserved from nematodes to humans. Lifespan-promoting conditions in nematodes include fasting…”
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RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils by Zaarur, Nava, Xu, Xiaobin, Lestienne, Patrick, Meriin, Anatoli B, McComb, Mark, Costello, Catherine E, Newnam, Gary P, Ganti, Rakhee, Romanova, Nina V, Shanmugasundaram, Maruda, Silva, Sara TN, Bandeiras, Tiago M, Matias, Pedro M, Lobachev, Kirill S, Lednev, Igor K, Chernoff, Yury O, Sherman, Michael Y

“…The aggresome is an organelle that recruits aggregated proteins for storage and degradation. We performed an siRNA screen for proteins involved in aggresome…”
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Molecular determinants of selective clearance of protein inclusions by autophagy by Wong, Esther, Bejarano, Eloy, Rakshit, Moumita, Lee, Karen, Hanson, Hugo H., Zaarur, Nava, Phillips, Greg R., Sherman, Michael Y., Maria Cuervo, Ana

“…Protein quality control is essential for cellular survival. Failure to eliminate pathogenic proteins leads to their intracellular accumulation in the form of…”
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Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors by ZAARUR, Nava, GABAI, Vladimir L, PORCO, John A, CALDERWOOD, Stuart, SHERMAN, Michael Y

“…Novel classes of anticancer drugs, including proteasome inhibitors and Hsp90 inhibitors, potently induce heat shock proteins (Hsps). Because Hsps show…”
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Stereocontrolled Synthesis of a Complex Library via Elaboration of Angular Epoxyquinol Scaffolds by Lei, Xiaoguang, Zaarur, Nava, Sherman, Michael Y, Porco, John A

“…We have accomplished the synthesis of a complex chemical library via elaboration of angular epoxyquinol scaffolds with distinct skeletal frameworks. The key…”
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Triggering Aggresome Formation by Zaarur, Nava, Meriin, Anatoli B., Gabai, Vladimir L., Sherman, Michael Y.

“…Abnormal polypeptides that escape proteasome-dependent degradation and aggregate in cytosol can be transported via microtubules to an aggresome, a recently…”
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Akt may associate with insulin‐responsive vesicles via interaction with sortilin by Zaarur, Nava, Meriin, Anatoli B., Singh, Maneet, Goel, Raghuveera K., Zaia, Joseph, Kandror, Konstantin V.

“…Insulin‐responsive vesicles (IRVs) deliver the glucose transporter Glut4 to the plasma membrane in response to activation of the insulin signaling cascade:…”
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Detection of Detergent-sensitive Interactions Between Membrane Proteins by Zaarur, Nava, Pan, Xiang, Kandror, Konstantin V.

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Association of translation factor eEF1A with defective ribosomal products generates a signal for aggresome formation by Meriin, Anatoli B, Zaarur, Nava, Sherman, Michael Y

“…Aggresome formation is initiated upon proteasome failure, and facilitates autophagic clearance of protein aggregates to protect cells from proteotoxicity. Here…”
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Detection of Detergent-sensitive Interactions Between Membrane Proteins by Zaarur, Nava, Pan, Xiang, Kandror, Konstantin V

“…Our ability to explore protein-protein interactions is the key to understanding regulatory connections in the cell. However, detection of protein-protein…”
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Triggering aggresome formation. Dissecting aggresome-targeting and aggregation signals in synphilin 1 by Zaarur, Nava, Meriin, Anatoli B, Gabai, Vladimir L, Sherman, Michael Y

“…Abnormal polypeptides that escape proteasome-dependent degradation and aggregate in cytosol can be transported via microtubules to an aggresome, a recently…”
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A high-content screen identifies novel compounds that inhibit stress-induced TDP-43 cellular aggregation and associated cytotoxicity by Boyd, Justin D, Lee, Peter, Feiler, Marisa S, Zauur, Nava, Liu, Min, Concannon, John, Ebata, Atsushi, Wolozin, Benjamin, Glicksman, Marcie A

“…TDP-43 is an RNA binding protein found to accumulate in the cytoplasm of brain and spinal cord from patients affected with amyotrophic lateral sclerosis (ALS)…”
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A Novel Approach to Recovery of Function of Mutant Proteins by Slowing Down Translation by Meriin, Anatoli B., Mense, Martin, Colbert, Jeff D., Liang, Feng, Bihler, Hermann, Zaarur, Nava, Rock, Kenneth L., Sherman, Michael Y.

“…Protein homeostasis depends on a balance of translation, folding, and degradation. Here, we demonstrate that mild inhibition of translation results in a…”
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Abnormal proteins can form aggresome in yeast: aggresome-targeting signals and components of the machinery by Wang, Yan, Meriin, Anatoli B, Zaarur, Nava, Romanova, Nina V, Chernoff, Yury O, Costello, Catherine E, Sherman, Michael Y

“…In mammalian cells, abnormal proteins that escape proteasome-dependent degradation form small aggregates that can be transported into a centrosome-associated…”
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Correction: Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue by Liu-Yesucevitz, Liqun, Bilgutay, Aylin, Zhang, Yong-Jie, Vanderweyde, Tara, Citro, Allison, Mehta, Tapan, Zaarur, Nava, McKee, Ann, Bowser, Robert, Sherman, Michael, Petrucelli, Leonard, Wolozin, Benjamin

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Tar DNA Binding Protein-43 by Liu-Yesucevitz, Liqun, Bilgutay, Aylin, Zhang, Yong-Jie, Vanderwyde, Tara, Citro, Allison, Mehta, Tapan, Zaarur, Nava, McKee, Ann, Bowser, Robert, Sherman, Michael, Petrucelli, Leonard, Wolozin, Benjamin

“…Tar DNA Binding Protein-43 (TDP-43) is a principle component of inclusions in many cases of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral…”
Get full text

Correction: Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue by Liqun Liu-Yesucevitz, Aylin Bilgutay, Yong-Jie Zhang, Tara Vanderweyde, Allison Citro, Tapan Mehta, Nava Zaarur, Ann McKee, Robert Bowser, Michael Sherman, Leonard Petrucelli, Benjamin Wolozin

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