Search Results - "Nauseef, W. M."

Characterization of Staphylococcus aureus Cardiolipin Synthases 1 and 2 and Their Contribution to Accumulation of Cardiolipin in Stationary Phase and within Phagocytes by KOPRIVNJAK, T, ZHANG, D, ERNST, C. M, PESCHEL, A, NAUSEEF, W. M, WEISS, J. P

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Salmonella Pathogenicity Island 2-Encoded Type III Secretion System Mediates Exclusion of NADPH Oxidase Assembly from the Phagosomal Membrane by Gallois, Annabelle, Klein, Joanna R, Allen, Lee-Ann H, Jones, Bradley D, Nauseef, William M

“…Salmonella typhimurium requires a type III secretion system encoded by pathogenicity island (SPI)-2 to survive and proliferate within macrophages. This…”
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Neutrophils exposed to bacterial lipopolysaccharide upregulate NADPH oxidase assembly by DeLeo, F R, Renee, J, McCormick, S, Nakamura, M, Apicella, M, Weiss, J P, Nauseef, W M

“…Bacterial LPS is a pluripotent agonist for PMNs. Although it does not activate the NADPH-dependent oxidase directly, LPS renders PMNs more responsive to other…”
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Two cytosolic components of the human neutrophil respiratory burst oxidase translocate to the plasma membrane during cell activation by CLARK, R. A, VOLPP, B. D, LEIDAL, K. G, NAUSEEF, W. M

“…The superoxide-forming respiratory burst oxidase of human neutrophils is composed of membrane-associated catalytic components and cytosolic constituents…”
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Assembly of the neutrophil respiratory burst oxidase. Protein kinase C promotes cytoskeletal and membrane association of cytosolic oxidase components by Nauseef, W M, Volpp, B D, McCormick, S, Leidal, K G, Clark, R A

“…Activated human polymorphonuclear neutrophils (PMNs) convert molecular oxygen into superoxide anion, a process known as the respiratory burst, through the…”
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Cloning of the cDNA and Functional Expression of the 47-Kilodalton Cytosolic Component of Human Neutrophil Respiratory Burst Oxidase by Volpp, Bryan D., Nauseef, William M., Donelson, John E., Moser, David R., Clark, Robert A.

“…Neutrophil NADPH oxidase is a multicomponent enzyme that is activated to generate superoxide anion and is defective in the cells of patients with chronic…”
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Insights into myeloperoxidase biosynthesis from its inherited deficiency by NAUSEEF, W. M

“…Myeloperoxidase (MPO) is a heme protein present in the granules of neutrophils and monocytes. The activated neutrophil releases MPO into the phagolysosome or…”
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The proper study of mankind by Nauseef, W M

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Transient Association of the Nicotinamide Adenine Dinucleotide Phosphate Oxidase Subunits p47phox and p67phox With Phagosomes in Neutrophils From Patients With X-Linked Chronic Granulomatous Disease by Allen, Lee-Ann H., DeLeo, Frank R., Gallois, Annabelle, Toyoshima, Satoshi, Suzuki, Kensuke, Nauseef, William M.

“…Optimal microbicidal activity of polymorphonuclear leukocytes (PMNs) requires recruitment of a functional nicotinamide adenine dinucleotide phosphate (NADPH)…”
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Sorting for storage in myeloid cells of nonmyeloid proteins and chimeras with the propeptide of myeloperoxidase precursor by Bülow, E., Nauseef, W. M., Goedken, M., McCormick, S., Calafat, J., Gullberg, U., Olsson, I.

“…During formation of polymorphonuclear neutrophils, proteins are synthesized for storage in granules. Whereas sorting of proteins into distinct subtypes of…”
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Editorial: Celebrating the 50th anniversary of the seminal discovery that the phagocyte respiratory burst enzyme is an NADPH oxidase by Berton, G., Castaldi, M. A., Cassatella, M. A., Nauseef, W. M.

“…Commemorative of Dr. Filippo Rossi’s demonstration that the phagocyte respiratory burst enzyme is an NADPH oxidase…”
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Primary inherited defects in neutrophil function: etiology and treatment by Malech, H L, Nauseef, W M

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Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly : translocation of p47-phox and p67-phox requires interaction between p47-phox cytochrome b558 by HEYWORTH, P. G, CURNUTTE, J. T, NAUSEEF, W. M, VOLPP, B. D, PEARSON, D. W, ROSEN, H, CLARK, R. A

“…Two of the cytosolic NADPH oxidase components, p47-phox and p67-phox, translocate to the plasma membrane in normal neutrophils stimulated with phorbol…”
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Pattern of inheritance in hereditary myeloperoxidase deficiency associated with the R569W missense mutation by Nauseef, W. M., Cogley, M., Bock, S., Petrides, P. E.

“…Myeloperoxidase (MPO) is an essential component of the oxygen‐dependent microbicidal system of neutrophils and monocytes. Hereditary deficiency of MPO occurs…”
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NADPH oxidase of human neutrophils. Subcellular localization and characterization of an arachidonate-activatable superoxide-generating system by Clark, R.A., Leidal, K.G., Pearson, D.W., Nauseef, W.M.

“…The superoxide-forming NADPH oxidase of human neutrophils was studied in subcellular fractions of unstimulated cells. Purified neutrophils were disrupted by…”
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The NADPH-dependent oxidase of phagocytes by Nauseef, W M

“…Polymorphonuclear leukocytes (PMNs) represent a prominent cellular element in the innate immune system, serving to ingest exogenous particles and microbes and…”
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Two Cytosolic Neutrophil Oxidase Components Absent in Autosomal Chronic Granulomatous Disease by Volpp, Bryan D., Nauseef, William M., Clark, Robert A.

“…Neutrophils kill microorganisms with oxygen radicals generated by an oxidase that uses the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH)…”
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Impact of missense mutations on biosynthesis of myeloperoxidase by Nauseef, W M, McCormick, S, Goedken, M

“…We have examined the biosynthesis of normal and mutant forms of myeloperoxidase (MPO) in order to gain insights into the critical features of normal biogenesis…”
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Functional domain in an arginine-rich carboxyl-terminal region of p47phox by NAUSEEF, W. M, MCCORMICK, S, RENEE, J, LEIDAL, K. G, CLARK, R. A

“…Activation of the neutrophil respiratory burst oxidase involves phosphorylation-dependent translocation of the cytosolic proteins p47phox and p67phox to the…”
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Myeloperoxidase deficiency by Nauseef, W M

“…MPO activity is critical for optimal microbicidal activity of normal PMNs. In the absence of MPO, auxiliary mechanisms protect most MPO-deficient hosts from…”
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