Search Results - "Naundorf, S"

Lentivirus-induced ‘Smart’ dendritic cells: Pharmacodynamics and GMP-compliant production for immunotherapy against TRP2-positive melanoma by Sundarasetty, B S, Chan, L, Darling, D, Giunti, G, Farzaneh, F, Schenck, F, Naundorf, S, Kuehlcke, K, Ruggiero, E, Schmidt, M, von Kalle, C, Rothe, M, Hoon, D S B, Gerasch, L, Figueiredo, C, Koehl, U, Blasczyk, R, Gutzmer, R, Stripecke, R

“…Monocyte-derived conventional dendritic cells (ConvDCs) loaded with melanoma antigens showed modest responses in clinical trials. Efficacy studies were…”
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Airway surface liquid contains endogenous DNase activity which can be activated by exogenous magnesium by Rosenecker, Joseph, Naundorf, S, Rudolph, C

“…The removal of highly viscous mucus from the airways is an important task in the treatment of chronic lung disease like in cystic fibrosis. The inhalation of…”
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Generation and qualification of a GMP compliant master cell stock of CAR expressing ErbB2-specific NK-92 cells for clinical trials by Nowakowska, P, Odendahl, M.K, Wels, W.S, Grez, M, Naundorf, S, Bönig, H, Seifried, E, Tonn, T

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Interaction of bronchoalveolar lavage fluid with polyplexes and lipoplexes: analysing the role of proteins and glycoproteins by Rosenecker, J., Naundorf, S., Gersting, S. W., Hauck, R. W., Gessner, A., Nicklaus, P., Müller, R. H., Rudolph, C.

“…Background Plasmid DNA complexed with cationic lipids (lipoplexes) or cationic polymers (polyplexes) has been used for gene transfer into the lung. Topical…”
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Retroviral vector insertions in T-lymphocytes used for suicide gene therapy occur in gene groups with specific molecular functions by GIORDANO, F. A, FEHSE, B, ZELLER, W. J, HO, A. D, FRUEHAUF, S, LAUFS, S, HOTZ-WAGENBLATT, A, JONNAKUTY, S, DEL VAL, C, APPELT, J.-U, NAGY, K. Z, KUEHLCKE, K, NAUNDORF, S, ZANDER, A. R

“…Graft-versus-host disease (GvHD) is a severe complication in the context of allogeneic stem cell transplantation and adoptive immunotherapy. The transfer of a…”
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Retroviral MDR1 gene transfer into marrow-engrafting human peripheral blood progenitor cells results in preferential transgene expression in the immature myeloid compartment rather than in mature myeloid progeny in vivo by Buss, E.C., Laufs, S., Naundorf, S., Kuehlcke, K., Nagy, K.Z., Zeller, W.J., Fruehauf, S.

“…The objective of multidrug resistance-1 (MDR1) gene therapy is protection of the myeloid cell lineage. It is therefore important to examine the effect of…”
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Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1 , PRDM16 or SETBP1 by von Kalle, Christof, Grez, Manuel, Ott, Marion G, Schmidt, Manfred, Schwarzwaelder, Kerstin, Stein, Stefan, Siler, Ulrich, Koehl, Ulrike, Glimm, Hanno, Kühlcke, Klaus, Schilz, Andrea, Kunkel, Hana, Naundorf, Sonja, Brinkmann, Andrea, Deichmann, Annette, Fischer, Marlene, Ball, Claudia, Pilz, Ingo, Dunbar, Cynthia, Du, Yang, Jenkins, Nancy A, Copeland, Neal G, Lüthi, Ursula, Hassan, Moustapha, Thrasher, Adrian J, Hoelzer, Dieter, Seger, Reinhard

“…Gene transfer into hematopoietic stem cells has been used successfully for correcting lymphoid but not myeloid immunodeficiencies. Here we report on two adults…”
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Retroviral vector integration occurs in preferred genomic targets of human bone marrow–repopulating cells by Laufs, Stephanie, Gentner, Bernhard, Nagy, K. Zsuzsanna, Jauch, Anna, Benner, Axel, Naundorf, Sonja, Kuehlcke, Klaus, Schiedlmeier, Bernhard, Ho, Anthony D., Zeller, W. Jens, Fruehauf, Stefan

“…Increasing use of hematopoietic stem cells for retroviral vector–mediated gene therapy and recent reports on insertional mutagenesis in mice and humans have…”
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In vivo gene delivery to the lung using polyethylenimine and fractured polyamidoamine dendrimers by Rudolph, Carsten, Lausier, James, Naundorf, Sonja, Müller, Rainer H., Rosenecker, Joseph

“…Background Gene transfer into the airways could be of importance for the treatment of chronic lung diseases such as cystic fibrosis. In the past few years…”
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In vitro and in vivo activity of MT201, a fully human monoclonal antibody for pancarcinoma treatment by Naundorf, Stefanie, Preithner, Susanne, Mayer, Petra, Lippold, Sandra, Wolf, Andreas, Hanakam, Frank, Fichtner, Iduna, Kufer, Peter, Raum, Tobias, Riethmüller, Gert, Baeuerle, Patrick A., Dreier, Torsten

“…In our study, a novel, fully human, recombinant monoclonal antibody of the IgG1 isotype, called MT201, was characterized for its binding properties,…”
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ERBB2/HER2-SPECIFIC NATURAL KILLER CELLS FOR ADOPTIVE IMMUNOTHERAPY OF GLIOBLASTOMA by Steinbach, J. P., Zhang, C., Burger, M., Jennewein, L., Schonfeld, K., Genssler, S., Sahm, C., Brendel, C., Naundorf, S., Odendahl, M., Kohl, U., Nowakowska, P., Seifried, E., Bonig, H., Tonn, T., Grez, M., Mittelbronn, M., Wels, W. S.

“…BACKGROUND: While EGFRvIII appears a logical target for immunotherapy, only a subpopulation of tumor cells express EGFRvIII and immune escape has been…”
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Clonal Analysis of Individual Marrow‐Repopulating Cells after Experimental Peripheral Blood Progenitor Cell Transplantation by Nagy, K. Zsuzsanna, Laufs, Stephanie, Gentner, Bernhard, Naundorf, Sonja, Kuehlcke, Klaus, Topaly, Julian, Buss, Eike C., Zeller, W. Jens, Fruehauf, Stefan

“…Methods to analyze the clonality of an adverse event in preclinical or clinical retroviral stem cell gene therapy protocols are needed. We analyzed the progeny…”
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Long-Term Follow-Up of Patients Treated by Gene Therapy for X-Linked Chronic Granulomatous Disease by Ott, Marion G., Grez, Manuel, Stein, Stefan, Siler, Ulrich, Koehl, Ulrike, Kuehlcke, Klaus, Schmidt, Manfred, Schilz, Andrea, Kunkel, Hana, Naundorf, Sonja, Brinkmann, Andrea, Hassan, Moustapha, von Kalle, Christof, Trasher, Adrian, Seger, Reinhard, Hoelzer, Dieter

“…Chronic granulomatous disease (CGD) is a primary immunodeficiency in which phagocytic cells of affected patients have impaired antimicrobial activity due to a…”
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In vivo gene delivery to the lung using polyethylenimine and fractured polyamidoamine dendrimers by Rudolph, C, Lausier, J, Naundorf, S, Mueller, R H, Rosenecker, J

“…Gene transfer into the airways could be of importance for the treatment of chronic lung diseases such as cystic fibrosis. In the past few years several…”
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