Search Results - "Naumov, Yuri N."

Role of cross-reactivity in cellular immune targeting of influenza A M158-66 variant peptide epitopes by Petrova, Galina V., Naumov, Yuri N., Naumova, Elena N., Gorski, Jack

“…The immunologic significance of cross-reactivity of TCR recognition of peptide:MHC complexes is still poorly understood. We have described TCR cross-reactivity…”
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Age-Based Dynamics of a Stable Circulating Cd8 T Cell Repertoire Component by Naumova, Elena N, Yassai, Maryam B, Demos, Wendy, Reed, Erica, Unruh, Melissa, Haribhai, Dipica, Williams, Calvin B, Naumov, Yuri N, Gorski, Jack

“…T-cell memory to pathogens can be envisioned as a receptor-based imprint of the pathogenic environment on the naïve repertoire of clonotypes. Recurrent…”
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Activation of CD1d-Restricted T Cells Protects NOD Mice from Developing Diabetes by Regulating Dendritic Cell Subsets by Naumov, Yuri N., Bahjat, Keith S., Gausling, Rudolph, Abraham, Roshini, Exley, Mark A., Koezuka, Yasuhiko, Balk, Steven B., Strominger, Jack L., Clare-Salzer, Michael, Wilson, S. Brian

“…CD1d-restricted invariant NKT (iNKT) cells are immunoregulatory cells whose loss exacerbates diabetes in nonobese diabetic (NOD) female mice. Here, we show…”
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Narrowing of human influenza A virus-specific T cell receptor α and β repertoires with increasing age by Gil, Anna, Yassai, Maryam B, Naumov, Yuri N, Selin, Liisa K

“…Alterations in memory CD8 T cell responses may contribute to the high morbidity and mortality caused by seasonal influenza A virus (IAV) infections in older…”
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CD1d-Restricted T Cells Regulate Dendritic Cell Function and Antitumor Immunity in a Granulocyte-Macrophage Colony-Stimulating Factor-Dependent Fashion by Gillessen, Silke, Naumov, Yuri N., Edward E. S. Nieuwenhuis, Exley, Mark A., Lee, Frederick S., Mach, Nicolas, Luster, Andrew D., Blumberg, Richard S., Taniguchi, Masaru, Balk, Steven P., Strominger, Jack L., Dranoff, Glenn, Wilson, S. Brian

“…CD1d-restricted T cells contribute to tumor protection, but their precise roles remain unclear. Here we show that tumor cells engineered to secrete…”
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Incorporating calendar effects to predict influenza seasonality in Milwaukee, Wisconsin by Simpson, Ryan B, Alarcon Falconi, Tania M, Venkat, Aishwarya, Chui, Kenneth H H, Navidad, Jose, Naumov, Yuri N, Gorski, Jack, Bhattacharyya, Sanjib, Naumova, Elena N

“…Social outings can trigger influenza transmission, especially in children and elderly. In contrast, school closures are associated with reduced influenza…”
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Memory of mice and men: CD8+ T-cell cross-reactivity and heterologous immunity by Selin, Liisa K., Brehm, Michael A., Naumov, Yuri N., Cornberg, Markus, Kim, Sung-Kwon, Clute, Shalyn C., Welsh, Raymond M.

“…The main functions of memory T cells are to provide protection upon re‐exposure to a pathogen and to prevent the re‐emergence of low‐grade persistent…”
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Quantitative measurement of pathogen-specific human memory T cell repertoire diversity using a CDR3 beta-specific microarray by Wang, Xujing, Jia, Shuang, Meyer, Lisa, Yassai, Maryam B, Naumov, Yuri N, Gorski, Jack, Hessner, Martin J

“…Providing quantitative microarray data that is sensitive to very small differences in target sequence would be a useful tool in any number of venues where a…”
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CD8 T Cell Cross-Reactivity Networks Mediate Heterologous Immunity in Human EBV and Murine Vaccinia Virus Infections by Cornberg, Markus, Clute, Shalyn C, Watkin, Levi B, Saccoccio, Frances M, Kim, Sung-Kwon, Naumov, Yuri N, Brehm, Michael A, Aslan, Nuray, Welsh, Raymond M, Selin, Liisa K

“…In this study, we demonstrate complex networks of CD8 T cell cross-reactivities between influenza A virus and EBV in humans and between lymphocytic…”
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Selective T cell expansion during aging of CD8 memory repertoires to influenza revealed by modeling by Naumov, Yuri N, Naumova, Elena N, Yassai, Maryam B, Gorski, Jack

“…The aging of T cell memory is often considered in terms of senescence, a process viewed as decay and loss of memory T cells. How senescence would affect memory…”
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Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes by Clute, Shalyn C, Naumov, Yuri N, Watkin, Levi B, Aslan, Nuray, Sullivan, John L, Thorley-Lawson, David A, Luzuriaga, Katherine, Welsh, Raymond M, Puzone, Roberto, Celada, Franco, Selin, Liisa K

“…Memory T cells cross-reactive with epitopes encoded by related or even unrelated viruses may alter the immune response and pathogenesis of infection by a…”
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Two Compensatory Pathways Maintain Long-Term Stability and Diversity in CD8 T Cell Memory Repertoires by Naumova, Elena N, Gorski, Jack, Naumov, Yuri N

“…The time-dependent changes of human memory T cell repertoires are still poorly understood. We define a T cell memory repertoire as the pool of clonotypic…”
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Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis by Clute, Shalyn C, Watkin, Levi B, Cornberg, Markus, Naumov, Yuri N, Sullivan, John L, Luzuriaga, Katherine, Welsh, Raymond M, Selin, Liisa K

“…The marked proliferation of activated CD8+ T cells is pathognomonic of EBV-associated infectious mononucleosis (IM), common in young adults. Since the…”
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A clonotype nomenclature for T cell receptors by Yassai, Maryam B., Naumov, Yuri N., Naumova, Elena N., Gorski, Jack

“…T cell receptor (TCR) nucleotide sequences are often generated during analyses of T cell responses to pathogens or autoantigens. The most important region of…”
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Multiple glycines in TCR alpha-chains determine clonally diverse nature of human T cell memory to influenza A virus by Naumov, Yuri N, Naumova, Elena N, Yassai, Maryam B, Kota, Kalyani, Welsh, Raymond M, Selin, Liisa K

“…Detailed assessment of how the structural properties of T cell receptors affect clonal repertoires of Ag-specific cells is a prerequisite for a better…”
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Complex T Cell Memory Repertoires Participate in Recall Responses at Extremes of Antigenic Load by Naumov, Yuri N, Naumova, Elena N, Clute, Shalyn C, Watkin, Levi B, Kota, Kalyani, Gorski, Jack, Selin, Liisa K

“…The CD8 T cell memory response to the HLA-A2-restricted influenza epitope M1(58-66) can be an instructive model of immune memory to a nonevolving epitope of a…”
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A Fractal Clonotype Distribution in the CD8+ Memory T Cell Repertoire Could Optimize Potential for Immune Responses by Naumov, Yuri N, Naumova, Elena N, Hogan, Kevin T, Selin, Liisa K, Gorski, Jack

“…The nature of CD8(+) T cell memory is still incompletely understood. We have previously reported that the response to an HLA-A2-restricted influenza-derived…”
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Disproportional effects in populations of concern for pandemic influenza: insights from seasonal epidemics in Wisconsin, 1967–2004 by Lofgren, Eric T., Wenger, Julia B., Fefferman, Nina H., Bina, David, Gradus, Steve, Bhattacharyya, Sanjib, Naumov, Yuri N., Gorski, Jack, Naumova, Elena N.

“…Please cite this paper as: Lofgren et al. (2010) Disproportional effects in populations of concern for pandemic influenza: insights from seasonal epidemics in…”
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Simulation Studies for a Multistage Dynamic Process of Immune Memory Response to Influenza: Experiment in silico by Naumova, Elena N, Gorski, Jack, Naumov, Yuri N

“…This communication provides an illustration for the use of computer simulations in human immunology. When traditional experiments are impossible, unethical, or…”
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A Class I MHC-Restricted Recall Response to a Viral Peptide Is Highly Polyclonal Despite Stringent CDR3 Selection: Implications for Establishing Memory T Cell Repertoires in "Real-World" Conditions by Naumov, Yuri N, Hogan, Kevin T, Naumova, Elena N, Pagel, Jeminah T, Gorski, Jack

“…In this study, we analyze the recall response to influenza A matrix peptide M1(58-66) restricted by HLA-A2 in one individual and find a strict CDR3 selection…”
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