Search Results - "Naumann, Ivonne"

Examination of betahistine bioavailability in combination with the monoamine oxidase B inhibitor, selegiline, in humans—a non-randomized, single-sequence, two-period titration, open label single-center phase 1 study (PK-BeST) by Strupp, Michael, Churchill, Grant C., Naumann, Ivonne, Mansmann, Ulrich, Al Tawil, Amani, Golentsova, Anastasia, Goldschagg, Nicolina

“…BackgroundBetahistine was registered in Europe in the 1970s and approved in more than 80 countries as a first-line treatment for Menière's disease. It has been…”
Get full text

G-Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1 by Richter, Günther HS, Fasan, Annette, Hauer, Kristina, Grunewald, Thomas GP, Berns, Colette, Rössler, Sabine, Naumann, Ivonne, Staege, Martin S., Fulda, Simone, Esposito, Irene, Burdach, Stefan

“…Metastatic spread in Ewing sarcomas (ES) is frequent and haematogenous. G‐protein coupled receptor 64 (GPR64), an orphan receptor with normal expression…”
Get full text

PI3K inhibition enhances doxorubicin-induced apoptosis in sarcoma cells by Marklein, Diana, Graab, Ulrike, Naumann, Ivonne, Yan, Tiandong, Ridzewski, Rosalie, Nitzki, Frauke, Rosenberger, Albert, Dittmann, Kai, Wienands, Jürgen, Wojnowski, Leszek, Fulda, Simone, Hahn, Heidi

“…We searched for a drug capable of sensitization of sarcoma cells to doxorubicin (DOX). We report that the dual PI3K/mTOR inhibitor PI103 enhances the efficacy…”
Get full text

Targeting Aberrant PI3K/Akt Activation by PI103 Restores Sensitivity to TRAIL-Induced Apoptosis in Neuroblastoma by OPEL, Daniela, NAUMANN, Ivonne, SCHNEIDER, Maxi, BERTELE, Daniela, DEBATIN, Klaus-Michael, FULDA, Simone

“…Because we recently identified Akt activation as a novel poor prognostic indicator in neuroblastoma, we investigated whether phosphoinositide 3'-kinase (PI3K)…”
Get full text

Bortezomib Primes Neuroblastoma Cells for TRAIL-Induced Apoptosis by Linking the Death Receptor to the Mitochondrial Pathway by NAUMANN, Ivonne, KAPPLER, Roland, VON SCHWEINITZ, Dietrich, DEBATIN, Klaus-Michael, FULDA, Simone

“…Searching for novel strategies to modulate apoptosis in neuroblastoma, we investigated the potential of the proteasome inhibitor bortezomib. The effect of…”
Get full text

The cytotoxic potential of interleukin-15-stimulated cytokine-induced killer cells against leukemia cells by Rettinger, Eva, KuçI, Selim, Naumann, Ivonne, Becker, Petra, Kreyenberg, Hermann, Anzaghe, Martina, Willasch, Andre, Koehl, Ulrike, Bug, Gesine, Ruthardt, Martin, Klingebiel, Thomas, Fulda, Simone, Bader, Peter

“…Abstract Background aims Cytokine-induced killer (CIK) cells may serve as an alternative approach to adoptive donor lymphocyte infusions (DLI) for patients…”
Get full text

Safety and Efficacy of Acetyl-DL-Leucine in Certain Types of Cerebellar Ataxia: The ALCAT Randomized Clinical Crossover Trial by Feil, Katharina, Adrion, Christine, Boesch, Sylvia, Doss, Sarah, Giordano, Ilaria, Hengel, Holger, Jacobi, Heike, Klockgether, Thomas, Klopstock, Thomas, Nachbauer, Wolfgang, Schöls, Ludger, Steiner, Katharina Marie, Stendel, Claudia, Timmann, Dagmar, Naumann, Ivonne, Mansmann, Ulrich, Strupp, Michael

“…Cerebellar ataxia is a neurodegenerative disease impairing motor function characterized by ataxia of stance, gait, speech, and fine motor disturbances. To…”
Get full text

Effects of acetyl-DL-leucine on cerebellar ataxia (ALCAT trial): study protocol for a multicenter, multinational, randomized, double-blind, placebo-controlled, crossover phase III trial by Feil, Katharina, Adrion, Christine, Teufel, Julian, Bösch, Sylvia, Claassen, Jens, Giordano, Ilaria, Hengel, Holger, Jacobi, Heike, Klockgether, Thomas, Klopstock, Thomas, Nachbauer, Wolfgang, Schöls, Ludger, Stendel, Claudia, Uslar, Ellen, van de Warrenburg, Bart, Berger, Ingrid, Naumann, Ivonne, Bayer, Otmar, Müller, Hans-Helge, Mansmann, Ulrich, Strupp, Michael

“…Cerebellar ataxia (CA) is a frequent and often disabling condition that impairs motor functioning and impacts on quality of life (QoL). No medication has yet…”
Get full text

Abstract 4341: Bortezomib primes neuroblastoma cells for TRAIL- triggered apoptosis by linking the death receptor to the mitochondrial pathway by Naumann, Ivonne, Kappler, Roland, von Schweinitz, Dietrich, Debatin, Klaus-Michael, Fulda, Simone

“…In contrast to remarkable improvements in the survival and cure rates that have been encountered for many childhood malignancies, the prognosis of children…”
Get full text

Identification of sulfoglycolipids from the alga Porphyridium purpureum by matrix-assisted laser desorption/ionisation quadrupole ion trap time-of-flight mass spectrometry by Naumann, Ivonne, Darsow, Kai H., Walter, Christian, Lange, Harald A., Buchholz, Rainer

“…Sulfoglycolipids, isolated from different phototrophic organisms, particularly plants and algae, have already been identified as bioactive compounds. In…”
Get full text

Identification of sulfoquinovosyldiacyglycerides from Phaeodactylum tricornutum by matrix-assisted laser desorption/ionization QTrap time-of-flight hybrid mass spectrometry by Naumann, Ivonne, Klein, Barbara C., Bartel, Sebastian J., Darsow, Kai H., Buchholz, Rainer, Lange, Harald A.

“…The pharmaceutical industry is interested in identifying novel target compounds. Due to their versatile pharmacological activities (e.g. antiviral,…”
Get full text

IDENTIFICATION OF COENZYME Q10 FROM PORPHYRIDIUM PURPUREUM (RHODOPHYTA) BY MATRIX-ASSISTED LASER DESORPTION IONIZATION CURVED FIELD REFLECTRON MASS SPECTROMETRY1: COENZYME Q10 FROM PORPHYRIDIUM PURPUREUM by Klein, Barbara C., Bartel, Sebastian J., Darsow, Kai H., Naumann, Ivonne, Walter, Christian, Buchholz, Rainer, Lange, Harald A.

Get full text

IDENTIFICATION OF COENZYME Q₁₀ FROM PORPHYRIDIUM PURPUREUM (RHODOPHYTA) BY MATRIX-ASSISTED LASER DESORPTION IONIZATION CURVED FIELD REFLECTRON MASS SPECTROMETRY by Klein, Barbara C, Bartel, Sebastian J, Darsow, Kai H, Naumann, Ivonne, Walter, Christian, Buchholz, Rainer, Lange, Harald A

“…Antioxidant agents from natural sources are currently the focus of scientific interest and are part of several natural product screenings. Coenzymes Q (CoQ,…”
Get full text

IDENTIFICATION OF COENZYME Q10 FROM PORPHYRIDIUM PURPUREUM (RHODOPHYTA) BY MATRIX‐ASSISTED LASER DESORPTION IONIZATION CURVED FIELD REFLECTRON MASS SPECTROMETRY1 by Klein, Barbara C., Bartel, Sebastian J., Darsow, Kai H., Naumann, Ivonne, Walter, Christian, Buchholz, Rainer, Lange, Harald A.

“…Antioxidant agents from natural sources are currently the focus of scientific interest and are part of several natural product screenings. Coenzymes Q (CoQ,…”
Get full text

IDENTIFICATION OF COENZYME Q 10 FROM PORPHYRIDIUM PURPUREUM (RHODOPHYTA) BY MATRIX-ASSISTED LASER DESORPTION IONIZATION CURVED FIELD REFLECTRON MASS SPECTROMETRY 1 by Klein, Barbara C, Bartel, Sebastian J, Darsow, Kai H, Naumann, Ivonne, Walter, Christian, Buchholz, Rainer, Lange, Harald A

“…Antioxidant agents from natural sources are currently the focus of scientific interest and are part of several natural product screenings. Coenzymes Q (CoQ,…”
Get full text

Sulfoquinovosyldiacylglyceride - antiviral aktive substanzen by Naumann, Ivonne

“…Die Substanzklasse der Sulfoquinovosyldiacylglyceride (SQDG) stellt eine Gruppe potentiell antiviraler Wirkstoffe aus phototrophen Mikroorganismen dar, an…”
Get full text