Search Results - "Naughton, Kassandra J."

Polycomb deficiency drives a FOXP2-high aggressive state targetable by epigenetic inhibitors by Chen, Fan, Byrd, Aria L., Liu, Jinpeng, Flight, Robert M., DuCote, Tanner J., Naughton, Kassandra J., Song, Xiulong, Edgin, Abigail R., Lukyanchuk, Alexsandr, Dixon, Danielle T., Gosser, Christian M., Esoe, Dave-Preston, Jayswal, Rani D., Orkin, Stuart H., Moseley, Hunter N. B., Wang, Chi, Brainson, Christine Fillmore

“…Inhibitors of the Polycomb Repressive Complex 2 (PRC2) histone methyltransferase EZH2 are approved for certain cancers, but realizing their wider utility…”
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Dysregulated Polycomb Repressive Complex 2 contributes to chronic obstructive pulmonary disease by rewiring stem cell fate by Byrd, Aria L., Qu, Xufeng, Lukyanchuk, Alexsandr, Liu, Jinpeng, Chen, Fan, Naughton, Kassandra J., DuCote, Tanner J., Song, Xiulong, Bowman, Hannah C., Zhao, Yanming, Edgin, Abigail R., Wang, Chi, Liu, Jinze, Brainson, Christine Fillmore

“…Aberrant lung cell differentiation is a hallmark of many lung diseases including chronic obstructive pulmonary disease (COPD). The EZH2-containing Polycomb…”
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Cellular Origins of EGFR‐Driven Lung Cancer Cells Determine Sensitivity to Therapy by Chen, Fan, Liu, Jinpeng, Flight, Robert M., Naughton, Kassandra J., Lukyanchuk, Alexsandr, Edgin, Abigail R., Song, Xiulong, Zhang, Haikuo, Wong, Kwok‐Kin, Moseley, Hunter N. B., Wang, Chi, Brainson, Christine F.

“…Targeting the epidermal growth factor receptor (EGFR) with tyrosine kinase inhibitors (TKIs) is one of the major precision medicine treatment options for lung…”
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Therapeutic potential of tumor-infiltrating lymphocytes in non-small cell lung cancer by Plaugher, Daniel R., Childress, Avery R., Gosser, Christian M., Esoe, Dave-Preston, Naughton, Kassandra J., Hao, Zhonglin, Brainson, Christine F.

“…Lung cancer is the leading cause of cancer-related death worldwide, with poor outcomes even for those diagnosed at early stages. Current standard-of-care for…”
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Using Artificial Intelligence to Identify Tumor Microenvironment Heterogeneity in Non–Small Cell Lung Cancers by DuCote, Tanner J., Naughton, Kassandra J., Skaggs, Erika M., Bocklage, Therese J., Allison, Derek B., Brainson, Christine F.

“…Lung cancer heterogeneity is a major barrier to effective treatments and encompasses not only the malignant epithelial cell phenotypes and genetics but also…”
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Using 3-Dimensional Cultures to Propagate Genetically Modified Lung Organoids by Chen, Fan, Naughton, Kassandra J, Lee, Joo-Hyeon, Brainson, Christine F

“…Transformed lung organoids have extensive applications in lung cancer modeling and drug screening. Traditional two-dimensional (2D) cultures fail to propagate…”
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EZH2 Inhibition Promotes Tumor Immunogenicity in Lung Squamous Cell Carcinomas by DuCote, Tanner J, Song, Xiulong, Naughton, Kassandra J, Chen, Fan, Plaugher, Daniel R, Childress, Avery R, Gellert, Abigail R, Skaggs, Erika M, Qu, Xufeng, Liu, Jinze, Liu, Jinpeng, Li, Fei, Wong, Kwok-Kin, Brainson, Christine F

“…Two important factors that contribute to resistance to immune checkpoint inhibitors (ICI) are an immune-suppressive microenvironment and limited antigen…”
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In Vivo Assembly of a Genetically Encoded Artificial Metalloenzyme for Hydrogen Production by Naughton, Kassandra J, Treviño, Regina E, Moore, Peter J, Wertz, Ashlee E, Dickson, J. Alex, Shafaat, Hannah S

“…The genetic encoding of artificial enzymes represents a substantial advantage relative to traditional molecular catalyst optimization, as laboratory-based…”
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