Search Results - "Naughton, Brigitte"

p97/UBXD1 Generate Ubiquitylated Proteins That Are Sequestered into Nuclear Envelope Herniations in Torsin-Deficient Cells by Prophet, Sarah M, Naughton, Brigitte S, Schlieker, Christian

“…DYT1 dystonia is a debilitating neurological movement disorder that arises upon Torsin ATPase deficiency. Nuclear envelope (NE) blebs that contain…”
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Dynamic quality control machinery that operates across compartmental borders mediates the degradation of mammalian nuclear membrane proteins by Tsai, Pei-Ling, Cameron, Christopher J F, Forni, Maria Fernanda, Wasko, Renee R, Naughton, Brigitte S, Horsley, Valerie, Gerstein, Mark B, Schlieker, Christian

“…Many human diseases are caused by mutations in nuclear envelope (NE) proteins. How protein homeostasis and disease etiology are interconnected at the NE is…”
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Mechanisms of Protein Translocation on DNA Are Differentially Responsive to Water Activity by Naughton, Brigitte S, Reich, Norbert O

“…Water plays important but poorly understood roles in the functions of most biomolecules. We are interested in understanding how proteins use diverse search…”
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Characterization of Specific N -α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library by Kung, Pei-Pei, Bingham, Patrick, Burke, Benjamin J., Chen, Qiuxia, Cheng, Xuemin, Deng, Ya-Li, Dou, Dengfeng, Feng, Junli, Gallego, Gary M., Gehring, Michael R., Grant, Stephan K., Greasley, Samantha, Harris, Anthony R., Maegley, Karen A., Meier, Jordan, Meng, Xiaoyun, Montano, Jose L., Morgan, Barry A., Naughton, Brigitte S., Palde, Prakash B., Paul, Thomas A., Richardson, Paul, Sakata, Sylvie, Shaginian, Alex, Sonnenburg, William K., Subramanyam, Chakrapani, Timofeevski, Sergei, Wan, Jinqiao, Yan, Wen, Stewart, Albert E.

“…Two novel compounds were identified as Naa50 binders/inhibitors using DNA-encoded technology screening. Biophysical and biochemical data as well as cocrystal…”
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Specificity versus Processivity in the Sequential Modification of DNA: A Study of DNA Adenine Methyltransferase by Barel, Itay, Naughton, Brigitte, Reich, Norbert O, Brown, Frank L. H

“…A detailed analysis is carried out on both published experimental results and new experiments for the methylation kinetics of two-site DNA substrates (with…”
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The role of water dynamics in mediating protein‐DNA interactions (549.4) by Naughton, Brigitte, Pollak, Adam, Han, Songi, Reich, Norbert

“…The role of hydration water on protein and DNA surfaces is fundamental to their interaction and processes, yet experimentally challenging to study. We recently…”
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