Search Results - "Naughton, Bartholomew J"

Blood genome-wide transcriptional profiles reflect broad molecular impairments and strong blood-brain links in Alzheimer's disease by Naughton, Bartholomew J, Duncan, F Jason, Murrey, Darren A, Meadows, Aaron S, Newsom, David E, Stoicea, Nicoleta, White, Peter, Scharre, Douglas W, Mccarty, Douglas M, Fu, Haiyan

“…To date, little is known regarding the etiology and disease mechanisms of Alzheimer's disease (AD). There is a general urgency for novel approaches to advance…”
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Broad Functional Correction of Molecular Impairments by Systemic Delivery of scAAVrh74-hSGSH Gene Delivery in MPS IIIA Mice by Duncan, F Jason, Naughton, Bartholomew J, Zaraspe, Kimberly, Murrey, Darren A, Meadows, Aaron S, Clark, Kelly Reed, Newsom, David E, White, Peter, Fu, Haiyan, McCarty, Douglas M

“…Mucopolysaccharidosis (MPS) IIIA is a neuropathic lysosomal storage disease caused by deficiency in N-sulfoglucosamine sulfohydrolase (SGSH). Genome-wide gene…”
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Feasibility and safety of systemic rAAV9-hNAGLU delivery for treating mucopolysaccharidosis IIIB: toxicology, biodistribution, and immunological assessments in primates by Murrey, Darren A, Naughton, Bartholomew J, Duncan, F Jason, Meadows, Aaron S, Ware, Tierra A, Campbell, Katie J, Bremer, William G, Walker, Christopher M, Goodchild, Laurie, Bolon, Brad, La Perle, Krista, Flanigan, Kevin M, McBride, Kim L, McCarty, Douglas M, Fu, Haiyan

“…No treatment is currently available for mucopolysaccharidosis (MPS) IIIB, a neuropathic lysosomal storage disease caused by autosomal recessive defect in…”
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Amyloidosis, synucleinopathy, and prion encephalopathy in a neuropathic lysosomal storage disease: the CNS-biomarker potential of peripheral blood by Naughton, Bartholomew J, Duncan, F Jason, Murrey, Darren, Ware, Tierra, Meadows, Aaron, McCarty, Douglas M, Fu, Haiyan

“…Mucopolysaccharidosis (MPS) IIIB is a devastating neuropathic lysosomal storage disease with complex pathology. This study identifies molecular signatures in…”
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Dopamine transporter inhibition is necessary for cocaine-induced increases in dendritic spine density in the nucleus accumbens by Martin, Bradley J., Naughton, Bartholomew J., Thirtamara-Rajamani, Keerthi, Yoon, Daniel J., Han, Dawn D., Devries, A. Courtney, Gu, Howard H.

“…Repeated exposure to cocaine produces changes in the nervous system that facilitate drug‐seeking behaviors. These drug‐seeking behaviors have been studied with…”
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A GLP-Compliant Toxicology and Biodistribution Study: Systemic Delivery of an rAAV9 Vector for the Treatment of Mucopolysaccharidosis IIIB by Meadows, Aaron S, Duncan, F Jason, Camboni, Marybeth, Waligura, Kathryn, Montgomery, Chrystal, Zaraspe, Kimberly, Naughton, Bartholomew J, Bremer, William G, Shilling, Christopher, Walker, Christopher M, Bolon, Brad, Flanigan, Kevin M, McBride, Kim L, McCarty, Douglas M, Fu, Haiyan

“…No treatment is currently available for mucopolysaccharidosis (MPS) IIIB, a neuropathic lysosomal storage disease due to defect in α-N-acetylglucosaminidase…”
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Amyloidosis, Synucleinopathy, and Prion Encephalopathy in a Neuropathic Lysosomal Storage Disease: The CNS-Biomarker Potential of Peripheral Blood: e80142 by Naughton, Bartholomew J, Duncan, F Jason, Murrey, Darren, Ware, Tierra, Meadows, Aaron, McCarty, Douglas M, Fu, Haiyan

“…Mucopolysaccharidosis (MPS) IIIB is a devastating neuropathic lysosomal storage disease with complex pathology. This study identifies molecular signatures in…”
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Brain Region and Cell Type Specific Approaches to Study Drug Abuse by Naughton, Bartholomew J

“…Drug dependence is a persistent problem throughout the world. Once addicted to a drug, many users have difficulty quitting use, even when they desire to stop…”
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