Search Results - "Nature reviews. Rheumatology"

Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology by Schrezenmeier, Eva, Dörner, Thomas

“…Despite widespread clinical use of antimalarial drugs such as hydroxychloroquine and chloroquine in the treatment of rheumatoid arthritis (RA), systemic lupus…”
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Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors by Dehlin, Mats, Jacobsson, Lennart, Roddy, Edward

“…Gout is the most common inflammatory arthritis and occurs when hyperuricaemia, sustained elevation of serum urate levels resulting in supersaturation of body…”
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Mechanisms and therapeutic implications of cellular senescence in osteoarthritis by Coryell, Philip R., Diekman, Brian O., Loeser, Richard F.

“…The development of osteoarthritis (OA) correlates with a rise in the number of senescent cells in joint tissues, and the senescence-associated secretory…”
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Surgical and tissue engineering strategies for articular cartilage and meniscus repair by Kwon, Heenam, Brown, Wendy E., Lee, Cassandra A., Wang, Dean, Paschos, Nikolaos, Hu, Jerry C., Athanasiou, Kyriacos A.

“…Injuries to articular cartilage and menisci can lead to cartilage degeneration that ultimately results in arthritis. Different forms of arthritis affect ~50…”
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Methotrexate and its mechanisms of action in inflammatory arthritis by Cronstein, Bruce N., Aune, Thomas M.

“…Despite the introduction of numerous biologic agents for the treatment of rheumatoid arthritis (RA) and other forms of inflammatory arthritis, low-dose…”
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Mechanisms of joint destruction in rheumatoid arthritis — immune cell–fibroblast–bone interactions by Komatsu, Noriko, Takayanagi, Hiroshi

“…Rheumatoid arthritis (RA) is characterized by inflammation and destruction of bone and cartilage in affected joints. Autoimmune responses lead to increased…”
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Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases by Hinz, Boris, Lagares, David

“…Organ fibrosis is a lethal outcome of autoimmune rheumatic diseases such as systemic sclerosis. Myofibroblasts are scar-forming cells that are ultimately…”
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Synovial inflammation in osteoarthritis progression by Sanchez-Lopez, Elsa, Coras, Roxana, Torres, Alyssa, Lane, Nancy E., Guma, Monica

“…Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration. Synovial inflammation is present in the OA joint and has been…”
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Emerging pharmaceutical therapies for osteoarthritis by Latourte, Augustin, Kloppenburg, Margreet, Richette, Pascal

“…The prevalence of osteoarthritis (OA) and the burden associated with the disease are steadily increasing worldwide, representing a major public health…”
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Systemic and organ-specific immune-related manifestations of COVID-19 by Ramos-Casals, Manuel, Brito-Zerón, Pilar, Mariette, Xavier

“…Immune-related manifestations are increasingly recognized conditions in patients with COVID-19, with around 3,000 cases reported worldwide comprising more than…”
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Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis by Robinson, William H., Lepus, Christin M., Wang, Qian, Raghu, Harini, Mao, Rong, Lindstrom, Tamsin M., Sokolove, Jeremy

“…Key Points Osteoarthritis (OA) represents the failure of the joint as an organ Synovitis is increasingly recognized as a characteristic of the OA joint, and…”
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Global epidemiology of rheumatoid arthritis by Finckh, Axel, Gilbert, Benoît, Hodkinson, Bridget, Bae, Sang-Cheol, Thomas, Ranjeny, Deane, Kevin D., Alpizar-Rodriguez, Deshiré, Lauper, Kim

“…Rheumatoid arthritis (RA) is a systemic autoimmune disease that predominantly affects the joints. The prevalence of RA varies globally, with generally a higher…”
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IgG4-related disease: an update on pathophysiology and implications for clinical care by Perugino, Cory A., Stone, John H.

“…IgG4-related disease (IgG4-RD) has only existed as a unique disease entity since 2003, yet remarkable progress has already been achieved in describing the…”
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Intra-articular treatment options for knee osteoarthritis by Jones, Ian A., Togashi, Ryan, Wilson, Melissa L., Heckmann, Nathanael, Vangsness, C. Thomas

“…Intra-articular drug delivery has a number of advantages over systemic administration; however, for the past 20 years, intra-articular treatment options for…”
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Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): updated treatment recommendations for psoriatic arthritis 2021 by Coates, Laura C., Soriano, Enrique R., Corp, Nadia, Bertheussen, Heidi, Callis Duffin, Kristina, Campanholo, Cristiano B., Chau, Jeffrey, Eder, Lihi, Fernández-Ávila, Daniel G., FitzGerald, Oliver, Garg, Amit, Gladman, Dafna D., Goel, Niti, Helliwell, Philip S., Husni, M. Elaine, Jadon, Deepak R., Katz, Arnon, Laheru, Dhruvkumar, Latella, John, Leung, Ying-Ying, Lindsay, Christine, Lubrano, Ennio, Mazzuoccolo, Luis Daniel, Mease, Philip J., O’Sullivan, Denis, Ogdie, Alexis, Olsder, Wendy, Palominos, Penelope Esther, Schick, Lori, Steinkoenig, Ingrid, de Wit, Maarten, van der Windt, D. A., Kavanaugh, Arthur

“…Since the second version of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) treatment recommendations were published in…”
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Early-stage symptomatic osteoarthritis of the knee — time for action by Mahmoudian, Armaghan, Lohmander, L. Stefan, Mobasheri, Ali, Englund, Martin, Luyten, Frank P.

“…Osteoarthritis (OA) remains the most challenging arthritic disorder, with a high burden of disease and no available disease-modifying treatments. Symptomatic…”
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TNF biology, pathogenic mechanisms and emerging therapeutic strategies by Kalliolias, George D., Ivashkiv, Lionel B.

“…Key Points TNF is a pleiotropic cytokine that exerts homeostatic and pathogenic bioactivities A new concept in therapeutics of TNF-mediated diseases is the…”
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Pathogenesis and therapeutic interventions for ANCA-associated vasculitis by Nakazawa, Daigo, Masuda, Sakiko, Tomaru, Utano, Ishizu, Akihiro

“…Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) affects systemic small vessels and is accompanied by the presence of ANCAs in the…”
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The role of metabolism in the pathogenesis of osteoarthritis by Mobasheri, Ali, Rayman, Margaret P., Gualillo, Oreste, Sellam, Jérémie, van der Kraan, Peter, Fearon, Ursula

“…Key Points Metabolism has a key role in the physiological turnover of synovial joint tissues, including articular cartilage In osteoarthritis (OA),…”
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Therapeutic options for targeting inflammatory osteoarthritis pain by Conaghan, Philip G., Cook, Andrew D., Hamilton, John A., Tak, Paul P.

“…Pain is the major symptom of osteoarthritis (OA) and is an important factor in strategies to manage this disease. However, the current standard of care does…”
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