Search Results - "Nature reviews. Neuroscience"

Backpropagation and the brain by Lillicrap, Timothy P., Santoro, Adam, Marris, Luke, Akerman, Colin J., Hinton, Geoffrey

“…During learning, the brain modifies synapses to improve behaviour. In the cortex, synapses are embedded within multilayered networks, making it difficult to…”
Get full text

Theories of consciousness by Seth, Anil K., Bayne, Tim

“…Recent years have seen a blossoming of theories about the biological and physical basis of consciousness. Good theories guide empirical research, allowing us…”
Get full text

Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing by Cabeza, Roberto, Albert, Marilyn, Belleville, Sylvie, Craik, Fergus I. M., Duarte, Audrey, Grady, Cheryl L., Lindenberger, Ulman, Nyberg, Lars, Park, Denise C., Reuter-Lorenz, Patricia A., Rugg, Michael D., Steffener, Jason, Rajah, M. Natasha

“…Cognitive ageing research examines the cognitive abilities that are preserved and/or those that decline with advanced age. There is great individual…”
Get full text

Locus coeruleus: a new look at the blue spot by Poe, Gina R., Foote, Stephen, Eschenko, Oxana, Johansen, Joshua P., Bouret, Sebastien, Aston-Jones, Gary, Harley, Carolyn W., Manahan-Vaughan, Denise, Weinshenker, David, Valentino, Rita, Berridge, Craig, Chandler, Daniel J., Waterhouse, Barry, Sara, Susan J.

“…The locus coeruleus (LC), or ‘blue spot’, is a small nucleus located deep in the brainstem that provides the far-reaching noradrenergic neurotransmitter system…”
Get full text

Non-motor features of Parkinson disease by Schapira, Anthony H.V., Chaudhuri, K. Ray, Jenner, Peter

“…Key Points Non-motor symptoms are common in Parkinson disease (PD) and can appear before motor features and progress in both severity and diversity as the…”
Get full text

Stress granules and neurodegeneration by Wolozin, Benjamin, Ivanov, Pavel

“…Recent advances suggest that the response of RNA metabolism to stress has an important role in the pathophysiology of neurodegenerative diseases, particularly…”
Get full text

Novel electrode technologies for neural recordings by Hong, Guosong, Lieber, Charles M.

“…Neural recording electrode technologies have contributed considerably to neuroscience by enabling the extracellular detection of low-frequency local field…”
Get full text

Microglial signatures and their role in health and disease by Butovsky, Oleg, Weiner, Howard L.

“…Microglia are the primary innate immune cells in the CNS. In the healthy brain, they exhibit a unique molecular homeostatic ‘signature’, consisting of a…”
Get full text

Lactate in the brain: from metabolic end-product to signalling molecule by Magistretti, Pierre J., Allaman, Igor

“…Much research has shown that lactate produced by astrocytes serves as a neuronal energy substrate. In this Review, Magistretti and Allaman describe this model…”
Get full text

Inflammasome signalling in brain function and neurodegenerative disease by Heneka, Michael T., McManus, Róisín M., Latz, Eicke

“…The mammalian CNS is an intricate and fragile structure, which on one hand is open to change in order to store information, but on the other hand is vulnerable…”
Get full text

Using second-person neuroscience to elucidate the mechanisms of social interaction by Redcay, Elizabeth, Schilbach, Leonhard

“…Although a large proportion of our lives are spent participating in social interactions, the investigation of the neural mechanisms supporting these…”
Get full text

Amyloid-β-independent regulators of tau pathology in Alzheimer disease by van der Kant, Rik, Goldstein, Lawrence S. B., Ossenkoppele, Rik

“…The global epidemic of Alzheimer disease (AD) is worsening, and no approved treatment can revert or arrest progression of this disease. AD pathology is…”
Get full text

Cognitive and behavioural flexibility: neural mechanisms and clinical considerations by Uddin, Lucina Q.

“…Cognitive and behavioural flexibility permit the appropriate adjustment of thoughts and behaviours in response to changing environmental demands. Brain…”
Get full text

Environmental influences on the pace of brain development by Tooley, Ursula A., Bassett, Danielle S., Mackey, Allyson P.

“…Childhood socio-economic status (SES), a measure of the availability of material and social resources, is one of the strongest predictors of lifelong…”
Get full text

Sensory perception in autism by Robertson, Caroline E., Baron-Cohen, Simon

“…Key Points Sensory symptoms have been observed since early reports of autism spectrum conditions but historically were thought to represent secondary…”
Get full text

Astrocytes in chronic pain and itch by Ji, Ru-Rong, Donnelly, Christopher R., Nedergaard, Maiken

“…Astrocytes are critical for maintaining the homeostasis of the CNS. Increasing evidence suggests that a number of neurological and neuropsychiatric disorders,…”
Get full text

The sleep-deprived human brain by Krause, Adam J., Simon, Eti Ben, Mander, Bryce A., Greer, Stephanie M., Saletin, Jared M., Goldstein-Piekarski, Andrea N., Walker, Matthew P.

“…Key Points Sleep deprivation triggers a set of bidirectional changes in brain activity and connectivity, depending on the specific cognitive or affective…”
Get full text

Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood by Anacker, Christoph, Hen, René

“…Key Points The ventral hippocampus is a crucial brain region in the neural circuitry that regulates mood and anxiety. Adult-born neurons in the dentate gyrus…”
Get full text

The dopamine motive system: implications for drug and food addiction by Volkow, Nora D., Wise, Roy A., Baler, Ruben

“…Key Points The motivation to eat, like the motivation to take addictive drugs, activates the forebrain dopamine systems. Excessive activation of this system…”
Get full text

If deep learning is the answer, what is the question? by Saxe, Andrew, Nelli, Stephanie, Summerfield, Christopher

“…Neuroscience research is undergoing a minor revolution. Recent advances in machine learning and artificial intelligence research have opened up new ways of…”
Get full text