Search Results - "Nature reviews. Neurology"

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here? by Leng, Fangda, Edison, Paul

“…Alzheimer disease (AD) is the most common form of neurodegenerative disease, estimated to contribute 60–70% of all cases of dementia worldwide. According to…”
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Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies by Yamazaki, Yu, Zhao, Na, Caulfield, Thomas R., Liu, Chia-Chen, Bu, Guojun

“…Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of late-onset Alzheimer disease (AD), with the APOE* ε 4 allele conferring…”
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Technology of deep brain stimulation: current status and future directions by Krauss, Joachim K., Lipsman, Nir, Aziz, Tipu, Boutet, Alexandre, Brown, Peter, Chang, Jin Woo, Davidson, Benjamin, Grill, Warren M., Hariz, Marwan I., Horn, Andreas, Schulder, Michael, Mammis, Antonios, Tass, Peter A., Volkmann, Jens, Lozano, Andres M.

“…Deep brain stimulation (DBS) is a neurosurgical procedure that allows targeted circuit-based neuromodulation. DBS is a standard of care in Parkinson disease,…”
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Cannabinoids and the expanded endocannabinoid system in neurological disorders by Cristino, Luigia, Bisogno, Tiziana, Di Marzo, Vincenzo

“…Anecdotal evidence that cannabis preparations have medical benefits together with the discovery of the psychotropic plant cannabinoid Δ 9 -tetrahydrocannabinol…”
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Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders by Sweeney, Melanie D., Sagare, Abhay P., Zlokovic, Berislav V.

“…Key Points The blood–brain barrier (BBB) protects neurons from factors present in the systemic circulation and maintains the highly regulated brain internal…”
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Deep brain stimulation: current challenges and future directions by Lozano, Andres M., Lipsman, Nir, Bergman, Hagai, Brown, Peter, Chabardes, Stephan, Chang, Jin Woo, Matthews, Keith, McIntyre, Cameron C., Schlaepfer, Thomas E., Schulder, Michael, Temel, Yasin, Volkmann, Jens, Krauss, Joachim K.

“…The clinical use of deep brain stimulation (DBS) is among the most important advances in the clinical neurosciences in the past two decades. As a surgical…”
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Perivascular spaces in the brain: anatomy, physiology and pathology by Wardlaw, Joanna M., Benveniste, Helene, Nedergaard, Maiken, Zlokovic, Berislav V., Mestre, Humberto, Lee, Hedok, Doubal, Fergus N., Brown, Rosalind, Ramirez, Joel, MacIntosh, Bradley J., Tannenbaum, Allen, Ballerini, Lucia, Rungta, Ravi L., Boido, Davide, Sweeney, Melanie, Montagne, Axel, Charpak, Serge, Joutel, Anne, Smith, Kenneth J., Black, Sandra E.

“…Perivascular spaces include a variety of passageways around arterioles, capillaries and venules in the brain, along which a range of substances can move…”
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Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways by Greenberg, Steven M., Bacskai, Brian J., Hernandez-Guillamon, Mar, Pruzin, Jeremy, Sperling, Reisa, van Veluw, Susanne J.

“…The shared role of amyloid-β (Aβ) deposition in cerebral amyloid angiopathy (CAA) and Alzheimer disease (AD) is arguably the clearest instance of crosstalk…”
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Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy by Vezzani, Annamaria, Balosso, Silvia, Ravizza, Teresa

“…Epilepsy is a chronic neurological disease characterized by an enduring propensity for generation of seizures. The pathogenic processes of seizure generation…”
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Diagnosis and management of Guillain–Barré syndrome in ten steps by Leonhard, Sonja E., Mandarakas, Melissa R., Gondim, Francisco A. A., Bateman, Kathleen, Ferreira, Maria L. B., Cornblath, David R., van Doorn, Pieter A., Dourado, Mario E., Hughes, Richard A. C., Islam, Badrul, Kusunoki, Susumu, Pardo, Carlos A., Reisin, Ricardo, Sejvar, James J., Shahrizaila, Nortina, Soares, Cristiane, Umapathi, Thirugnanam, Wang, Yuzhong, Yiu, Eppie M., Willison, Hugh J., Jacobs, Bart C.

“…Guillain–Barré syndrome (GBS) is a rare, but potentially fatal, immune-mediated disease of the peripheral nerves and nerve roots that is usually triggered by…”
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Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums by Arnold, Steven E., Arvanitakis, Zoe, Macauley-Rambach, Shannon L., Koenig, Aaron M., Wang, Hoau-Yan, Ahima, Rexford S., Craft, Suzanne, Gandy, Sam, Buettner, Christoph, Stoeckel, Luke E., Holtzman, David M., Nathan, David M.

“…Key Points The molecular signalling pathways through which insulin exerts its actions in the body also mediate its roles in synaptic neurotransmission,…”
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Tau-targeting therapies for Alzheimer disease by Congdon, Erin E., Sigurdsson, Einar M.

“…Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is characterized by amyloid plaques and neurofibrillary tangles in the brain,…”
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Maternal immune activation and neuroinflammation in human neurodevelopmental disorders by Han, Velda X., Patel, Shrujna, Jones, Hannah F., Dale, Russell C.

“…Maternal health during pregnancy plays a major role in shaping health and disease risks in the offspring. The maternal immune activation hypothesis proposes…”
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CGRP as the target of new migraine therapies — successful translation from bench to clinic by Edvinsson, Lars, Haanes, Kristian Agmund, Warfvinge, Karin, Krause, Diana N.

“…Treatment of migraine is on the cusp of a new era with the development of drugs that target the trigeminal sensory neuropeptide calcitonin gene-related peptide…”
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Ageing as a risk factor for neurodegenerative disease by Hou, Yujun, Dan, Xiuli, Babbar, Mansi, Wei, Yong, Hasselbalch, Steen G., Croteau, Deborah L., Bohr, Vilhelm A.

“…Ageing is the primary risk factor for most neurodegenerative diseases, including Alzheimer disease (AD) and Parkinson disease (PD). One in ten individuals aged…”
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Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic by Hampel, Harald, O’Bryant, Sid E., Molinuevo, José L., Zetterberg, Henrik, Masters, Colin L., Lista, Simone, Kiddle, Steven J., Batrla, Richard, Blennow, Kaj

“…Biomarker discovery and development for clinical research, diagnostics and therapy monitoring in clinical trials have advanced rapidly in key areas of medicine…”
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Peripheral and central immune system crosstalk in Alzheimer disease — a research prospectus by Bettcher, Brianne M., Tansey, Malú G., Dorothée, Guillaume, Heneka, Michael T.

“…Dysregulation of the immune system is a cardinal feature of Alzheimer disease (AD), and a considerable body of evidence indicates pathological alterations in…”
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C9orf72-mediated ALS and FTD: multiple pathways to disease by Balendra, Rubika, Isaacs, Adrian M.

“…The discovery that repeat expansions in the C9orf72 gene are a frequent cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) has…”
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ER stress and the unfolded protein response in neurodegeneration by Hetz, Claudio, Saxena, Smita

“…Key Points Many neurodegenerative diseases involve the accumulation of protein aggregates Endoplasmic reticulum (ER) stress triggers activation of the unfolded…”
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Parkinson disease and the immune system — associations, mechanisms and therapeutics by Tan, Eng-King, Chao, Yin-Xia, West, Andrew, Chan, Ling-Ling, Poewe, Werner, Jankovic, Joseph

“…Multiple lines of evidence indicate that immune system dysfunction has a role in Parkinson disease (PD); this evidence includes clinical and genetic…”
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