Search Results - "Nature reviews. Molecular cell biology"

Ferroptosis: mechanisms, biology and role in disease by Jiang, Xuejun, Stockwell, Brent R., Conrad, Marcus

“…The research field of ferroptosis has seen exponential growth over the past few years, since the term was coined in 2012. This unique modality of cell death,…”
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Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology by Sies, Helmut, Belousov, Vsevolod V., Chandel, Navdeep S., Davies, Michael J., Jones, Dean P., Mann, Giovanni E., Murphy, Michael P., Yamamoto, Masayuki, Winterbourn, Christine

“…‘Reactive oxygen species’ (ROS) is a generic term that defines a wide variety of oxidant molecules with vastly different properties and biological functions…”
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Mechanisms, regulation and functions of the unfolded protein response by Hetz, Claudio, Zhang, Kezhong, Kaufman, Randal J.

“…Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at the endoplasmic reticulum (ER) is emerging as a possible driver of…”
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Guidelines and definitions for research on epithelial–mesenchymal transition by Yang, Jing, Antin, Parker, Berx, Geert, Blanpain, Cédric, Brabletz, Thomas, Bronner, Marianne, Campbell, Kyra, Cano, Amparo, Casanova, Jordi, Christofori, Gerhard, Dedhar, Shoukat, Derynck, Rik, Ford, Heide L., Fuxe, Jonas, García de Herreros, Antonio, Goodall, Gregory J., Hadjantonakis, Anna-Katerina, Huang, Ruby Y. J., Kalcheim, Chaya, Kalluri, Raghu, Kang, Yibin, Khew-Goodall, Yeesim, Levine, Herbert, Liu, Jinsong, Longmore, Gregory D., Mani, Sendurai A., Massagué, Joan, Mayor, Roberto, McClay, David, Mostov, Keith E., Newgreen, Donald F., Nieto, M. Angela, Puisieux, Alain, Runyan, Raymond, Savagner, Pierre, Stanger, Ben, Stemmler, Marc P., Takahashi, Yoshiko, Takeichi, Masatoshi, Theveneau, Eric, Thiery, Jean Paul, Thompson, Erik W., Weinberg, Robert A., Williams, Elizabeth D., Xing, Jianhua, Zhou, Binhua P., Sheng, Guojun

“…Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to…”
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Mitochondria as multifaceted regulators of cell death by Bock, Florian J., Tait, Stephen W. G.

“…Through their many and varied metabolic functions, mitochondria power life. Paradoxically, mitochondria also have a central role in apoptotic cell death. Upon…”
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Challenges and directions in studying cell–cell communication by extracellular vesicles by van Niel, Guillaume, Carter, David R. F., Clayton, Aled, Lambert, Daniel W., Raposo, Graça, Vader, Pieter

“…Extracellular vesicles (EVs) are increasingly recognized as important mediators of intercellular communication. They have important roles in numerous…”
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The expanding regulatory mechanisms and cellular functions of circular RNAs by Chen, Ling-Ling

“…Many protein-coding genes in higher eukaryotes can produce circular RNAs (circRNAs) through back-splicing of exons. CircRNAs differ from mRNAs in their…”
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Mechanisms and regulation of cholesterol homeostasis by Luo, Jie, Yang, Hongyuan, Song, Bao-Liang

“…Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed cholesterol balance underlies not only cardiovascular disease but also…”
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The diverse roles of DNA methylation in mammalian development and disease by Greenberg, Maxim V. C., Bourc’his, Deborah

“…DNA methylation is of paramount importance for mammalian embryonic development. DNA methylation has numerous functions: it is implicated in the repression of…”
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The regulation and functions of DNA and RNA G-quadruplexes by Varshney, Dhaval, Spiegel, Jochen, Zyner, Katherine, Tannahill, David, Balasubramanian, Shankar

“…DNA and RNA can adopt various secondary structures. Four-stranded G-quadruplex (G4) structures form through self-recognition of guanines into stacked tetrads,…”
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The mechanisms and roles of selective autophagy in mammals by Vargas, Jose Norberto S., Hamasaki, Maho, Kawabata, Tsuyoshi, Youle, Richard J., Yoshimori, Tamotsu

“…Autophagy is a process that targets various intracellular elements for degradation. Autophagy can be non-selective — associated with the indiscriminate…”
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Global view of human protein glycosylation pathways and functions by Schjoldager, Katrine T., Narimatsu, Yoshiki, Joshi, Hiren J., Clausen, Henrik

“…Glycosylation is the most abundant and diverse form of post-translational modification of proteins that is common to all eukaryotic cells. Enzymatic…”
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The cell biology of mitochondrial membrane dynamics by Giacomello, Marta, Pyakurel, Aswin, Glytsou, Christina, Scorrano, Luca

“…Owing to their ability to efficiently generate ATP required to sustain normal cell function, mitochondria are often considered the ‘powerhouses of the cell’…”
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Shedding light on the cell biology of extracellular vesicles by van Niel, Guillaume, D'Angelo, Gisela, Raposo, Graça

“…Key Points The secretion of extracellular vesicles was initially described as a means of selective elimination of proteins, lipids and RNA from cells. Now,…”
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Regulation of microRNA function in animals by Gebert, Luca F. R., MacRae, Ian J.

“…Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as key regulators of biological processes in animals. These small RNAs form…”
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Cellular adaptation to hypoxia through hypoxia inducible factors and beyond by Lee, Pearl, Chandel, Navdeep S., Simon, M. Celeste

“…Molecular oxygen (O 2 ) sustains intracellular bioenergetics and is consumed by numerous biochemical reactions, making it essential for most species on Earth…”
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Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins by Singh, Rumani, Letai, Anthony, Sarosiek, Kristopher

“…The loss of vital cells within healthy tissues contributes to the development, progression and treatment outcomes of many human disorders, including…”
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The next generation of CRISPR–Cas technologies and applications by Pickar-Oliver, Adrian, Gersbach, Charles A.

“…The prokaryote-derived CRISPR–Cas genome editing systems have transformed our ability to manipulate, detect, image and annotate specific DNA and RNA sequences…”
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Emerging connectivity of programmed cell death pathways and its physiological implications by Bedoui, Sammy, Herold, Marco J., Strasser, Andreas

“…The removal of functionally dispensable, infected or potentially neoplastic cells is driven by programmed cell death (PCD) pathways, highlighting their…”
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The assembly, regulation and function of the mitochondrial respiratory chain by Vercellino, Irene, Sazanov, Leonid A.

“…The mitochondrial oxidative phosphorylation system is central to cellular metabolism. It comprises five enzymatic complexes and two mobile electron carriers…”
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