Search Results - "Nature reviews. Immunology"

The trinity of COVID-19: immunity, inflammation and intervention by Tay, Matthew Zirui, Poh, Chek Meng, Rénia, Laurent, MacAry, Paul A., Ng, Lisa F. P.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic. Alongside…”
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The cGAS–STING pathway as a therapeutic target in inflammatory diseases by Decout, Alexiane, Katz, Jason D., Venkatraman, Shankar, Ablasser, Andrea

“…The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the settings of infection, cellular stress and tissue damage. Underlying…”
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Progress of the COVID-19 vaccine effort: viruses, vaccines and variants versus efficacy, effectiveness and escape by Tregoning, John S., Flight, Katie E., Higham, Sophie L., Wang, Ziyin, Pierce, Benjamin F.

“…Where 2020 saw the development and testing of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at an unprecedented pace, the first…”
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Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages by Merad, Miriam, Martin, Jerome C.

“…The COVID-19 pandemic caused by infection with SARS-CoV-2 has led to more than 200,000 deaths worldwide. Several studies have now established that the…”
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The NLRP3 inflammasome: molecular activation and regulation to therapeutics by Swanson, Karen V., Deng, Meng, Ting, Jenny P.-Y.

“…NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) is an intracellular sensor that detects a broad range of microbial motifs, endogenous danger signals…”
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COVID-19: immunopathology and its implications for therapy by Cao, Xuetao

“…Severe coronavirus disease 2019 (COVID-19) is characterized by pneumonia, lymphopenia, exhausted lymphocytes and a cytokine storm. Significant antibody…”
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Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities by Hajishengallis, George, Chavakis, Triantafyllos

“…Periodontitis, a major inflammatory disease of the oral mucosa, is epidemiologically associated with other chronic inflammation-driven disorders, including…”
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Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19 by Bonaventura, Aldo, Vecchié, Alessandra, Dagna, Lorenzo, Martinod, Kimberly, Dixon, Dave L., Van Tassell, Benjamin W., Dentali, Francesco, Montecucco, Fabrizio, Massberg, Steffen, Levi, Marcel, Abbate, Antonio

“…Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with…”
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Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions? by Akdis, Cezmi A.

“…There has been a steep increase in allergic and autoimmune diseases, reaching epidemic proportions and now affecting more than one billion people worldwide…”
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Neutralizing monoclonal antibodies for treatment of COVID-19 by Taylor, Peter C., Adams, Andrew C., Hufford, Matthew M., de la Torre, Inmaculada, Winthrop, Kevin, Gottlieb, Robert L.

“…Several neutralizing monoclonal antibodies (mAbs) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed and are now under…”
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The gasdermins, a protein family executing cell death and inflammation by Broz, Petr, Pelegrín, Pablo, Shao, Feng

“…The gasdermins are a family of recently identified pore-forming effector proteins that cause membrane permeabilization and pyroptosis, a lytic pro-inflammatory…”
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DAMP-sensing receptors in sterile inflammation and inflammatory diseases by Gong, Tao, Liu, Lei, Jiang, Wei, Zhou, Rongbin

“…The innate immune system has the capacity to detect ‘non-self’ molecules derived from pathogens, known as pathogen-associated molecular patterns, via pattern…”
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Considering how biological sex impacts immune responses and COVID-19 outcomes by Scully, Eileen P., Haverfield, Jenna, Ursin, Rebecca L., Tannenbaum, Cara, Klein, Sabra L.

“…A male bias in mortality has emerged in the COVID-19 pandemic, which is consistent with the pathogenesis of other viral infections. Biological sex differences…”
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IL-17 and IL-17-producing cells in protection versus pathology by Mills, Kingston H. G.

“…IL-17 cytokine family members have diverse biological functions, promoting protective immunity against many pathogens but also driving inflammatory pathology…”
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Immunological mechanisms of vaccine-induced protection against COVID-19 in humans by Sadarangani, Manish, Marchant, Arnaud, Kollmann, Tobias R.

“…Most COVID-19 vaccines are designed to elicit immune responses, ideally neutralizing antibodies (NAbs), against the SARS-CoV-2 spike protein. Several vaccines,…”
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TIM3 comes of age as an inhibitory receptor by Wolf, Yochai, Anderson, Ana C., Kuchroo, Vijay K.

“…T cell immunoglobulin and mucin domain-containing protein 3 (TIM3), a member of the TIM family, was originally identified as a receptor expressed on…”
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The inflammatory pathogenesis of colorectal cancer by Schmitt, Mark, Greten, Florian R.

“…The mutational landscape of colorectal cancer (CRC) does not enable predictions to be made about the survival of patients or their response to therapy…”
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Microglia and macrophages in brain homeostasis and disease by Li, Qingyun, Barres, Ben A.

“…Key Points Microglia arise solely from yolk sac erythromyeloid precursors under normal conditions, although the precise nature of these precursors is…”
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The diverse functions of the PD1 inhibitory pathway by Sharpe, Arlene H., Pauken, Kristen E.

“…Key Points Programmed cell death protein 1 (PD1) is an inhibitory receptor that is expressed by all T cells during activation. It regulates T cell effector…”
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The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease by Rothhammer, Veit, Quintana, Francisco J.

“…The environment, diet, microbiota and body’s metabolism shape complex biological processes in health and disease. However, our understanding of the molecular…”
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