Search Results - "Nature reviews. Cancer"

Targeting ferroptosis as a vulnerability in cancer by Lei, Guang, Zhuang, Li, Gan, Boyi

“…Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic build-up of lipid peroxides on cellular membranes. In recent…”
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A framework for advancing our understanding of cancer-associated fibroblasts by Sahai, Erik, Astsaturov, Igor, Cukierman, Edna, DeNardo, David G., Egeblad, Mikala, Evans, Ronald M., Fearon, Douglas, Greten, Florian R., Hingorani, Sunil R., Hunter, Tony, Hynes, Richard O., Jain, Rakesh K., Janowitz, Tobias, Jorgensen, Claus, Kimmelman, Alec C., Kolonin, Mikhail G., Maki, Robert G., Powers, R. Scott, Puré, Ellen, Ramirez, Daniel C., Scherz-Shouval, Ruth, Sherman, Mara H., Stewart, Sheila, Tlsty, Thea D., Tuveson, David A., Watt, Fiona M., Weaver, Valerie, Weeraratna, Ashani T., Werb, Zena

“…Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling,…”
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The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy by Havel, Jonathan J., Chowell, Diego, Chan, Timothy A.

“…Checkpoint inhibitor-based immunotherapies that target cytotoxic T lymphocyte antigen 4 (CTLA4) or the programmed cell death 1 (PD1) pathway have achieved…”
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The rediscovery of platinum-based cancer therapy by Rottenberg, Sven, Disler, Carmen, Perego, Paola

“…Platinum (Pt) compounds entered the clinic as anticancer agents when cisplatin was approved in 1978. More than 40 years later, even in the era of precision…”
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The metabolism of cancer cells during metastasis by Bergers, Gabriele, Fendt, Sarah-Maria

“…Metastasis formation is the major cause of death in most patients with cancer. Despite extensive research, targeting metastatic seeding and colonization is…”
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Tertiary lymphoid structures in the era of cancer immunotherapy by Sautès-Fridman, Catherine, Petitprez, Florent, Calderaro, Julien, Fridman, Wolf Herman

“…Tertiary lymphoid structures (TLSs) are ectopic lymphoid organs that develop in non-lymphoid tissues at sites of chronic inflammation including tumours. Key…”
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Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion by Friedmann Angeli, José Pedro, Krysko, Dmitri V., Conrad, Marcus

“…Ferroptosis is a recently recognized cell death modality that is morphologically, biochemically and genetically distinct from other forms of cell death and…”
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Key steps for effective breast cancer prevention by Britt, Kara L., Cuzick, Jack, Phillips, Kelly-Anne

“…Despite decades of laboratory, epidemiological and clinical research, breast cancer incidence continues to rise. Breast cancer remains the leading…”
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Revisiting the role of ABC transporters in multidrug-resistant cancer by Robey, Robert W., Pluchino, Kristen M., Hall, Matthew D., Fojo, Antonio T., Bates, Susan E., Gottesman, Michael M.

“…Most patients who die of cancer have disseminated disease that has become resistant to multiple therapeutic modalities. Ample evidence suggests that the…”
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Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy by Skoulidis, Ferdinandos, Heymach, John V.

“…The impressive clinical activity of small-molecule receptor tyrosine kinase inhibitors for oncogene-addicted subgroups of non-small-cell lung cancer (for…”
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Phagocytosis checkpoints as new targets for cancer immunotherapy by Feng, Mingye, Jiang, Wen, Kim, Betty Y. S., Zhang, Cheng Cheng, Fu, Yang-Xin, Weissman, Irving L.

“…Cancer immunotherapies targeting adaptive immune checkpoints have substantially improved patient outcomes across multiple metastatic and treatment-refractory…”
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p53: 800 million years of evolution and 40 years of discovery by Levine, Arnold J.

“…The evolutionarily conserved p53 protein and its cellular pathways mediate tumour suppression through an informed, regulated and integrated set of responses to…”
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Every step of the way: integrins in cancer progression and metastasis by Hamidi, Hellyeh, Ivaska, Johanna

“…Cell adhesion to the extracellular matrix is fundamental to tissue integrity and human health. Integrins are the main cellular adhesion receptors that through…”
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Targeting transcription factors in cancer — from undruggable to reality by Bushweller, John H.

“…Mutated or dysregulated transcription factors represent a unique class of drug targets that mediate aberrant gene expression, including blockade of…”
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The immunological and metabolic landscape in primary and metastatic liver cancer by Li, Xin, Ramadori, Pierluigi, Pfister, Dominik, Seehawer, Marco, Zender, Lars, Heikenwalder, Mathias

“…The liver is the sixth most common site of primary cancer in humans, and generally arises in a background of cirrhosis and inflammation. Moreover, the liver is…”
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The molecular landscape of head and neck cancer by Leemans, C. René, Snijders, Peter J. F., Brakenhoff, Ruud H.

“…Key Points There are major molecular differences between human papillomavirus (HPV)-positive and HPV-negative oropharyngeal cancers, and these underlie the…”
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Using immunotherapy to boost the abscopal effect by Ngwa, Wilfred, Irabor, Omoruyi Credit, Schoenfeld, Jonathan D., Hesser, Jürgen, Demaria, Sandra, Formenti, Silvia C.

“…The abscopal effect, which is the regression of metastatic cancer at distant sites during radiotherapy, is somewhat rare but can be promoted by immunotherapy…”
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The evolving translational potential of small extracellular vesicles in cancer by Möller, Andreas, Lobb, Richard J.

“…Cancer-derived extracellular vesicles (EVs) are regarded as having promising potential to be used as therapeutics and disease biomarkers. Mechanistically, EVs…”
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The role of ROS in tumour development and progression by Cheung, Eric C., Vousden, Karen H.

“…Eukaryotic cells have developed complex systems to regulate the production and response to reactive oxygen species (ROS). Different ROS control diverse aspects…”
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Cancer metabolism: looking forward by Martínez-Reyes, Inmaculada, Chandel, Navdeep S.

“…Tumour initiation and progression requires the metabolic reprogramming of cancer cells. Cancer cells autonomously alter their flux through various metabolic…”
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