Search Results - "Nature neuroscience"

Reactive astrocyte nomenclature, definitions, and future directions by Escartin, Carole, Galea, Elena, Lakatos, András, O’Callaghan, James P., Petzold, Gabor C., Serrano-Pozo, Alberto, Steinhäuser, Christian, Volterra, Andrea, Carmignoto, Giorgio, Agarwal, Amit, Allen, Nicola J., Araque, Alfonso, Barbeito, Luis, Barzilai, Ari, Bergles, Dwight E., Bonvento, Gilles, Butt, Arthur M., Chen, Wei-Ting, Cohen-Salmon, Martine, Cunningham, Colm, Deneen, Benjamin, De Strooper, Bart, Díaz-Castro, Blanca, Farina, Cinthia, Freeman, Marc, Gallo, Vittorio, Goldman, James E., Goldman, Steven A., Götz, Magdalena, Gutiérrez, Antonia, Haydon, Philip G., Heiland, Dieter H., Hol, Elly M., Holt, Matthew G., Iino, Masamitsu, Kastanenka, Ksenia V., Kettenmann, Helmut, Khakh, Baljit S., Koizumi, Schuichi, Lee, C. Justin, Liddelow, Shane A., MacVicar, Brian A., Magistretti, Pierre, Messing, Albee, Mishra, Anusha, Molofsky, Anna V., Murai, Keith K., Norris, Christopher M., Okada, Seiji, Oliet, Stéphane H. R., Oliveira, João F., Panatier, Aude, Parpura, Vladimir, Pekna, Marcela, Pekny, Milos, Pellerin, Luc, Perea, Gertrudis, Pérez-Nievas, Beatriz G., Pfrieger, Frank W., Poskanzer, Kira E., Quintana, Francisco J., Ransohoff, Richard M., Riquelme-Perez, Miriam, Robel, Stefanie, Rose, Christine R., Rothstein, Jeffrey D., Rouach, Nathalie, Rowitch, David H., Semyanov, Alexey, Sirko, Swetlana, Sontheimer, Harald, Swanson, Raymond A., Vitorica, Javier, Wanner, Ina-Beate, Wood, Levi B., Wu, Jiaqian, Zheng, Binhai, Zimmer, Eduardo R., Zorec, Robert, Sofroniew, Michael V., Verkhratsky, Alexei

“…Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS…”
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Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19 by Meinhardt, Jenny, Radke, Josefine, Dittmayer, Carsten, Franz, Jonas, Thomas, Carolina, Mothes, Ronja, Laue, Michael, Schneider, Julia, Brünink, Sebastian, Greuel, Selina, Lehmann, Malte, Hassan, Olga, Aschman, Tom, Schumann, Elisa, Chua, Robert Lorenz, Conrad, Christian, Eils, Roland, Stenzel, Werner, Windgassen, Marc, Rößler, Larissa, Goebel, Hans-Hilmar, Gelderblom, Hans R., Martin, Hubert, Nitsche, Andreas, Schulz-Schaeffer, Walter J., Hakroush, Samy, Winkler, Martin S., Tampe, Björn, Scheibe, Franziska, Körtvélyessy, Péter, Reinhold, Dirk, Siegmund, Britta, Kühl, Anja A., Elezkurtaj, Sefer, Horst, David, Oesterhelweg, Lars, Tsokos, Michael, Ingold-Heppner, Barbara, Stadelmann, Christine, Drosten, Christian, Corman, Victor Max, Radbruch, Helena, Heppner, Frank L.

“…The newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a pandemic respiratory disease. Moreover, thromboembolic…”
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Parameterizing neural power spectra into periodic and aperiodic components by Donoghue, Thomas, Haller, Matar, Peterson, Erik J., Varma, Paroma, Sebastian, Priyadarshini, Gao, Richard, Noto, Torben, Lara, Antonio H., Wallis, Joni D., Knight, Robert T., Shestyuk, Avgusta, Voytek, Bradley

“…Electrophysiological signals exhibit both periodic and aperiodic properties. Periodic oscillations have been linked to numerous physiological, cognitive,…”
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Synergy between amyloid-β and tau in Alzheimer’s disease by Busche, Marc Aurel, Hyman, Bradley T.

“…Patients with Alzheimer’s disease (AD) present with both extracellular amyloid-β (Aβ) plaques and intracellular tau-containing neurofibrillary tangles in the…”
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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions by Howard, David M., Adams, Mark J., Clarke, Toni-Kim, Hafferty, Jonathan D., Gibson, Jude, Shirali, Masoud, Coleman, Jonathan R. I., Hagenaars, Saskia P., Ward, Joey, Wigmore, Eleanor M., Alloza, Clara, Shen, Xueyi, Barbu, Miruna C., Xu, Eileen Y., Whalley, Heather C., Marioni, Riccardo E., Porteous, David J., Davies, Gail, Deary, Ian J., Hemani, Gibran, Berger, Klaus, Teismann, Henning, Rawal, Rajesh, Arolt, Volker, Baune, Bernhard T., Dannlowski, Udo, Domschke, Katharina, Tian, Chao, Hinds, David A., Trzaskowski, Maciej, Byrne, Enda M., Ripke, Stephan, Smith, Daniel J., Sullivan, Patrick F., Wray, Naomi R., Breen, Gerome, Lewis, Cathryn M., McIntosh, Andrew M.

“…Major depression is a debilitating psychiatric illness that is typically associated with low mood and anhedonia. Depression has a heritable component that has…”
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DeepLabCut: markerless pose estimation of user-defined body parts with deep learning by Mathis, Alexander, Mamidanna, Pranav, Cury, Kevin M., Abe, Taiga, Murthy, Venkatesh N., Mathis, Mackenzie Weygandt, Bethge, Matthias

“…Quantifying behavior is crucial for many applications in neuroscience. Videography provides easy methods for the observation and recording of animal behavior…”
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Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease by Fang, Evandro F., Hou, Yujun, Palikaras, Konstantinos, Adriaanse, Bryan A., Kerr, Jesse S., Yang, Beimeng, Lautrup, Sofie, Hasan-Olive, Md Mahdi, Caponio, Domenica, Dan, Xiuli, Rocktäschel, Paula, Croteau, Deborah L., Akbari, Mansour, Greig, Nigel H., Fladby, Tormod, Nilsen, Hilde, Cader, M. Zameel, Mattson, Mark P., Tavernarakis, Nektarios, Bohr, Vilhelm A.

“…Accumulation of damaged mitochondria is a hallmark of aging and age-related neurodegeneration, including Alzheimer’s disease (AD). The molecular mechanisms of…”
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A deep learning framework for neuroscience by Richards, Blake A., Lillicrap, Timothy P., Beaudoin, Philippe, Bengio, Yoshua, Bogacz, Rafal, Christensen, Amelia, Clopath, Claudia, Costa, Rui Ponte, de Berker, Archy, Ganguli, Surya, Gillon, Colleen J., Hafner, Danijar, Kepecs, Adam, Kriegeskorte, Nikolaus, Latham, Peter, Lindsay, Grace W., Miller, Kenneth D., Naud, Richard, Pack, Christopher C., Poirazi, Panayiota, Roelfsema, Pieter, Sacramento, João, Saxe, Andrew, Scellier, Benjamin, Schapiro, Anna C., Senn, Walter, Wayne, Greg, Yamins, Daniel, Zenke, Friedemann, Zylberberg, Joel, Therien, Denis, Kording, Konrad P.

“…Systems neuroscience seeks explanations for how the brain implements a wide variety of perceptual, cognitive and motor tasks. Conversely, artificial…”
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Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex by Maynard, Kristen R., Collado-Torres, Leonardo, Weber, Lukas M., Uytingco, Cedric, Barry, Brianna K., Williams, Stephen R., Catallini, Joseph L., Tran, Matthew N., Besich, Zachary, Tippani, Madhavi, Chew, Jennifer, Yin, Yifeng, Kleinman, Joel E., Hyde, Thomas M., Rao, Nikhil, Hicks, Stephanie C., Martinowich, Keri, Jaffe, Andrew E.

“…We used the 10x Genomics Visium platform to define the spatial topography of gene expression in the six-layered human dorsolateral prefrontal cortex. We…”
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Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain by Marschallinger, Julia, Iram, Tal, Zardeneta, Macy, Lee, Song E., Lehallier, Benoit, Haney, Michael S., Pluvinage, John V., Mathur, Vidhu, Hahn, Oliver, Morgens, David W., Kim, Justin, Tevini, Julia, Felder, Thomas K., Wolinski, Heimo, Bertozzi, Carolyn R., Bassik, Michael C., Aigner, Ludwig, Wyss-Coray, Tony

“…Microglia become progressively activated and seemingly dysfunctional with age, and genetic studies have linked these cells to the pathogenesis of a growing…”
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Microglia in neurodegeneration by Hickman, Suzanne, Izzy, Saef, Sen, Pritha, Morsett, Liza, El Khoury, Joseph

“…The neuroimmune system is involved in development, normal functioning, aging, and injury of the central nervous system. Microglia, first described a century…”
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Disease-associated astrocytes in Alzheimer’s disease and aging by Habib, Naomi, McCabe, Cristin, Medina, Sedi, Varshavsky, Miriam, Kitsberg, Daniel, Dvir-Szternfeld, Raz, Green, Gilad, Dionne, Danielle, Nguyen, Lan, Marshall, Jamie L., Chen, Fei, Zhang, Feng, Kaplan, Tommy, Regev, Aviv, Schwartz, Michal

“…The role of non-neuronal cells in Alzheimer’s disease progression has not been fully elucidated. Using single-nucleus RNA sequencing, we identified a…”
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Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques by Lee, Ju-Hyun, Yang, Dun-Sheng, Goulbourne, Chris N., Im, Eunju, Stavrides, Philip, Pensalfini, Anna, Chan, Han, Bouchet-Marquis, Cedric, Bleiwas, Cynthia, Berg, Martin J., Huo, Chunfeng, Peddy, James, Pawlik, Monika, Levy, Efrat, Rao, Mala, Staufenbiel, Mathias, Nixon, Ralph A.

“…Autophagy is markedly impaired in Alzheimer’s disease (AD). Here we reveal unique autophagy dysregulation within neurons in five AD mouse models in vivo and…”
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A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation by Grubman, Alexandra, Chew, Gabriel, Ouyang, John F., Sun, Guizhi, Choo, Xin Yi, McLean, Catriona, Simmons, Rebecca K., Buckberry, Sam, Vargas-Landin, Dulce B., Poppe, Daniel, Pflueger, Jahnvi, Lister, Ryan, Rackham, Owen J. L., Petretto, Enrico, Polo, Jose M.

“…There is currently little information available about how individual cell types contribute to Alzheimer’s disease. Here we applied single-nucleus RNA…”
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Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes by Shahmoradian, Sarah H., Lewis, Amanda J., Genoud, Christel, Hench, Jürgen, Moors, Tim E., Navarro, Paula P., Castaño-Díez, Daniel, Schweighauser, Gabriel, Graff-Meyer, Alexandra, Goldie, Kenneth N., Sütterlin, Rosmarie, Huisman, Evelien, Ingrassia, Angela, Gier, Yvonne de, Rozemuller, Annemieke J. M., Wang, Jing, Paepe, Anne De, Erny, Johannes, Staempfli, Andreas, Hoernschemeyer, Joerg, Großerüschkamp, Frederik, Niedieker, Daniel, El-Mashtoly, Samir F., Quadri, Marialuisa, Van IJcken, Wilfred F. J., Bonifati, Vincenzo, Gerwert, Klaus, Bohrmann, Bernd, Frank, Stephan, Britschgi, Markus, Stahlberg, Henning, Van de Berg, Wilma D. J., Lauer, Matthias E.

“…Parkinson’s disease, the most common age-related movement disorder, is a progressive neurodegenerative disease with unclear etiology. Key neuropathological…”
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Single-trial neural dynamics are dominated by richly varied movements by Musall, Simon, Kaufman, Matthew T., Juavinett, Ashley L., Gluf, Steven, Churchland, Anne K.

“…When experts are immersed in a task, do their brains prioritize task-related activity? Most efforts to understand neural activity during well-learned tasks…”
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Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization by Pombo Antunes, Ana Rita, Scheyltjens, Isabelle, Lodi, Francesca, Messiaen, Julie, Antoranz, Asier, Duerinck, Johnny, Kancheva, Daliya, Martens, Liesbet, De Vlaminck, Karen, Van Hove, Hannah, Kjølner Hansen, Signe Schmidt, Bosisio, Francesca Maria, Van der Borght, Koen, De Vleeschouwer, Steven, Sciot, Raf, Bouwens, Luc, Verfaillie, Michiel, Vandamme, Niels, Vandenbroucke, Roosmarijn E., De Wever, Olivier, Saeys, Yvan, Guilliams, Martin, Gysemans, Conny, Neyns, Bart, De Smet, Frederik, Lambrechts, Diether, Van Ginderachter, Jo A., Movahedi, Kiavash

“…Glioblastomas are aggressive primary brain cancers that recur as therapy-resistant tumors. Myeloid cells control glioblastoma malignancy, but their dynamics…”
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A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment by Van Hove, Hannah, Martens, Liesbet, Scheyltjens, Isabelle, De Vlaminck, Karen, Pombo Antunes, Ana Rita, De Prijck, Sofie, Vandamme, Niels, De Schepper, Sebastiaan, Van Isterdael, Gert, Scott, Charlotte L., Aerts, Jeroen, Berx, Geert, Boeckxstaens, Guy E., Vandenbroucke, Roosmarijn E., Vereecke, Lars, Moechars, Diederik, Guilliams, Martin, Van Ginderachter, Jo A., Saeys, Yvan, Movahedi, Kiavash

“…While the roles of parenchymal microglia in brain homeostasis and disease are fairly clear, other brain-resident myeloid cells remain less well understood. By…”
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Mechanisms of systems memory consolidation during sleep by Klinzing, Jens G., Niethard, Niels, Born, Jan

“…Long-term memory formation is a major function of sleep. Based on evidence from neurophysiological and behavioral studies mainly in humans and rodents, we…”
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Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model by Zhang, Peisu, Kishimoto, Yuki, Grammatikakis, Ioannis, Gottimukkala, Kamalvishnu, Cutler, Roy G., Zhang, Shiliang, Abdelmohsen, Kotb, Bohr, Vilhelm A., Misra Sen, Jyoti, Gorospe, Myriam, Mattson, Mark P.

“…Neuritic plaques, a pathological hallmark in Alzheimer’s disease (AD) brains, comprise extracellular aggregates of amyloid-beta (Aβ) peptide and degenerating…”
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