Search Results - "Nature immunology"

The T cell immune response against SARS-CoV-2 by Moss, Paul

“…The adaptive immune response is a major determinant of the clinical outcome after SARS-CoV-2 infection and underpins vaccine efficacy. T cell responses develop…”
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Immunogenic cell stress and death by Kroemer, Guido, Galassi, Claudia, Zitvogel, Laurence, Galluzzi, Lorenzo

“…Dying mammalian cells emit numerous signals that interact with the host to dictate the immunological correlates of cellular stress and death. In the absence of…”
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Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection by Phetsouphanh, Chansavath, Darley, David R., Wilson, Daniel B., Howe, Annett, Munier, C. Mee Ling, Patel, Sheila K., Juno, Jennifer A., Burrell, Louise M., Kent, Stephen J., Dore, Gregory J., Kelleher, Anthony D., Matthews, Gail V.

“…A proportion of patients surviving acute coronavirus disease 2019 (COVID-19) infection develop post-acute COVID syndrome (long COVID (LC)) lasting longer than…”
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Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19 by Peng, Yanchun, Mentzer, Alexander J., Liu, Guihai, Yao, Xuan, Yin, Zixi, Dong, Danning, Dejnirattisai, Wanwisa, Rostron, Timothy, Supasa, Piyada, Liu, Chang, López-Camacho, César, Slon-Campos, Jose, Zhao, Yuguang, Stuart, David I., Paesen, Guido C., Grimes, Jonathan M., Antson, Alfred A., Bayfield, Oliver W., Hawkins, Dorothy E. D. P., Ker, De-Sheng, Wang, Beibei, Turtle, Lance, Subramaniam, Krishanthi, Thomson, Paul, Zhang, Ping, Dold, Christina, Ratcliff, Jeremy, Simmonds, Peter, de Silva, Thushan, Sopp, Paul, Wellington, Dannielle, Rajapaksa, Ushani, Chen, Yi-Ling, Salio, Mariolina, Napolitani, Giorgio, Paes, Wayne, Borrow, Persephone, Kessler, Benedikt M., Fry, Jeremy W., Schwabe, Nikolai F., Semple, Malcolm G., Baillie, J. Kenneth, Moore, Shona C., Openshaw, Peter J. M., Ansari, M. Azim, Dunachie, Susanna, Barnes, Eleanor, Frater, John, Kerr, Georgina, Goulder, Philip, Lockett, Teresa, Levin, Robert, Zhang, Yonghong, Jing, Ronghua, Ho, Ling-Pei, Cornall, Richard J., Conlon, Christopher P., Klenerman, Paul, Screaton, Gavin R., Mongkolsapaya, Juthathip, McMichael, Andrew, Knight, Julian C., Ogg, Graham, Dong, Tao

“…The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We…”
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NLRP3 inflammasome in cancer and metabolic diseases by Sharma, Bhesh Raj, Kanneganti, Thirumala-Devi

“…The NLRP3 inflammasome is a multimeric cytosolic protein complex that assembles in response to cellular perturbations. This assembly leads to the activation of…”
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Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage by Aran, Dvir, Looney, Agnieszka P., Liu, Leqian, Wu, Esther, Fong, Valerie, Hsu, Austin, Chak, Suzanna, Naikawadi, Ram P., Wolters, Paul J., Abate, Adam R., Butte, Atul J., Bhattacharya, Mallar

“…Tissue fibrosis is a major cause of mortality that results from the deposition of matrix proteins by an activated mesenchyme. Macrophages accumulate in…”
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SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function by Winkler, Emma S., Bailey, Adam L., Kafai, Natasha M., Nair, Sharmila, McCune, Broc T., Yu, Jinsheng, Fox, Julie M., Chen, Rita E., Earnest, James T., Keeler, Shamus P., Ritter, Jon H., Kang, Liang-I, Dort, Sarah, Robichaud, Annette, Head, Richard, Holtzman, Michael J., Diamond, Michael S.

“…Although animal models have been evaluated for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, none have fully recapitulated the lung…”
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Pathological sequelae of long-haul COVID by Mehandru, Saurabh, Merad, Miriam

“…The world continues to contend with successive waves of coronavirus disease 2019 (COVID-19), fueled by the emergence of viral variants. At the same time,…”
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The complex role of tumor-infiltrating macrophages by Christofides, Anthos, Strauss, Laura, Yeo, Alan, Cao, Carol, Charest, Alain, Boussiotis, Vassiliki A.

“…Long recognized as an evolutionarily ancient cell type involved in tissue homeostasis and immune defense against pathogens, macrophages are being re-discovered…”
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FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation by Hu, Jun Jacob, Liu, Xing, Xia, Shiyu, Zhang, Zhibin, Zhang, Ying, Zhao, Jingxia, Ruan, Jianbin, Luo, Xuemei, Lou, Xiwen, Bai, Yang, Wang, Junhong, Hollingsworth, L. Robert, Magupalli, Venkat Giri, Zhao, Li, Luo, Hongbo R., Kim, Justin, Lieberman, Judy, Wu, Hao

“…Cytosolic sensing of pathogens and damage by myeloid and barrier epithelial cells assembles large complexes called inflammasomes, which activate inflammatory…”
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Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade by Miller, Brian C., Sen, Debattama R., Al Abosy, Rose, Bi, Kevin, Virkud, Yamini V., LaFleur, Martin W., Yates, Kathleen B., Lako, Ana, Felt, Kristen, Naik, Girish S., Manos, Michael, Gjini, Evisa, Kuchroo, Juhi R., Ishizuka, Jeffrey J., Collier, Jenna L., Griffin, Gabriel K., Maleri, Seth, Comstock, Dawn E., Weiss, Sarah A., Brown, Flavian D., Panda, Arpit, Zimmer, Margaret D., Manguso, Robert T., Hodi, F. Stephen, Rodig, Scott J., Sharpe, Arlene H., Haining, W. Nicholas

“…T cell dysfunction is a hallmark of many cancers, but the basis for T cell dysfunction and the mechanisms by which antibody blockade of the inhibitory receptor…”
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The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies by Kumagai, Shogo, Togashi, Yosuke, Kamada, Takahiro, Sugiyama, Eri, Nishinakamura, Hitomi, Takeuchi, Yoshiko, Vitaly, Kochin, Itahashi, Kota, Maeda, Yuka, Matsui, Shigeyuki, Shibahara, Takuma, Yamashita, Yasuho, Irie, Takuma, Tsuge, Ayaka, Fukuoka, Shota, Kawazoe, Akihito, Udagawa, Hibiki, Kirita, Keisuke, Aokage, Keiju, Ishii, Genichiro, Kuwata, Takeshi, Nakama, Kenta, Kawazu, Masahito, Ueno, Toshihide, Yamazaki, Naoya, Goto, Koichi, Tsuboi, Masahiro, Mano, Hiroyuki, Doi, Toshihiko, Shitara, Kohei, Nishikawa, Hiroyoshi

“…Immune checkpoint blockade has provided a paradigm shift in cancer therapy, but the success of this approach is very variable; therefore, biomarkers predictive…”
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Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19 by Woodruff, Matthew C., Ramonell, Richard P., Nguyen, Doan C., Cashman, Kevin S., Saini, Ankur Singh, Haddad, Natalie S., Ley, Ariel M., Kyu, Shuya, Howell, J. Christina, Ozturk, Tugba, Lee, Saeyun, Suryadevara, Naveenchandra, Case, James Brett, Bugrovsky, Regina, Chen, Weirong, Estrada, Jacob, Morrison-Porter, Andrea, Derrico, Andrew, Anam, Fabliha A., Sharma, Monika, Wu, Henry M., Le, Sang N., Jenks, Scott A., Tipton, Christopher M., Staitieh, Bashar, Daiss, John L., Ghosn, Eliver, Diamond, Michael S., Carnahan, Robert H., Crowe, James E., Hu, William T., Lee, F. Eun-Hyung, Sanz, Ignacio

“…A wide spectrum of clinical manifestations has become a hallmark of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 pandemic,…”
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Innate immunity: the first line of defense against SARS-CoV-2 by Diamond, Michael S., Kanneganti, Thirumala-Devi

“…The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial…”
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SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition by Nelde, Annika, Bilich, Tatjana, Heitmann, Jonas S., Maringer, Yacine, Salih, Helmut R., Roerden, Malte, Lübke, Maren, Bauer, Jens, Rieth, Jonas, Wacker, Marcel, Peter, Andreas, Hörber, Sebastian, Traenkle, Bjoern, Kaiser, Philipp D., Rothbauer, Ulrich, Becker, Matthias, Junker, Daniel, Krause, Gérard, Strengert, Monika, Schneiderhan-Marra, Nicole, Templin, Markus F., Joos, Thomas O., Kowalewski, Daniel J., Stos-Zweifel, Vlatka, Fehr, Michael, Rabsteyn, Armin, Mirakaj, Valbona, Karbach, Julia, Jäger, Elke, Graf, Michael, Gruber, Lena-Christin, Rachfalski, David, Preuß, Beate, Hagelstein, Ilona, Märklin, Melanie, Bakchoul, Tamam, Gouttefangeas, Cécile, Kohlbacher, Oliver, Klein, Reinhild, Stevanović, Stefan, Rammensee, Hans-Georg, Walz, Juliane S.

“…T cell immunity is central for the control of viral infections. To characterize T cell immunity, but also for the development of vaccines, identification of…”
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Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry by Zhang, Fan, Wei, Kevin, Slowikowski, Kamil, Fonseka, Chamith Y., Rao, Deepak A., Kelly, Stephen, Goodman, Susan M., Tabechian, Darren, Hughes, Laura B., Salomon-Escoto, Karen, Watts, Gerald F. M., Jonsson, A. Helena, Rangel-Moreno, Javier, Meednu, Nida, Rozo, Cristina, Apruzzese, William, Eisenhaure, Thomas M., Lieb, David J., Boyle, David L., Mandelin, Arthur M., Boyce, Brendan F., DiCarlo, Edward, Gravallese, Ellen M., Gregersen, Peter K., Moreland, Larry, Firestein, Gary S., Hacohen, Nir, Nusbaum, Chad, Lederer, James A., Perlman, Harris, Pitzalis, Costantino, Filer, Andrew, Holers, V. Michael, Bykerk, Vivian P., Donlin, Laura T., Anolik, Jennifer H., Brenner, Michael B., Raychaudhuri, Soumya

“…To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we applied single-cell RNA sequencing (scRNA-seq), mass cytometry,…”
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Single-cell landscape of immunological responses in patients with COVID-19 by Zhang, Ji-Yuan, Wang, Xiang-Ming, Xing, Xudong, Xu, Zhe, Zhang, Chao, Song, Jin-Wen, Fan, Xing, Xia, Peng, Fu, Jun-Liang, Wang, Si-Yu, Xu, Ruo-Nan, Dai, Xiao-Peng, Shi, Lei, Huang, Lei, Jiang, Tian-Jun, Shi, Ming, Zhang, Yuxia, Zumla, Alimuddin, Maeurer, Markus, Bai, Fan, Wang, Fu-Sheng

“…In coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the relationship between disease…”
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Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion by Scharping, Nicole E., Rivadeneira, Dayana B., Menk, Ashley V., Vignali, Paolo D. A., Ford, B. Rhodes, Rittenhouse, Natalie L., Peralta, Ronal, Wang, Yiyang, Wang, Yupeng, DePeaux, Kristin, Poholek, Amanda C., Delgoffe, Greg M.

“…Cancer and chronic infections induce T cell exhaustion, a hypofunctional fate carrying distinct epigenetic, transcriptomic and metabolic characteristics…”
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Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison by Galani, Ioanna-Evdokia, Rovina, Nikoletta, Lampropoulou, Vicky, Triantafyllia, Vasiliki, Manioudaki, Maria, Pavlos, Eleftherios, Koukaki, Evangelia, Fragkou, Paraskevi C., Panou, Vasiliki, Rapti, Vasiliki, Koltsida, Ourania, Mentis, Andreas, Koulouris, Nikolaos, Tsiodras, Sotirios, Koutsoukou, Antonia, Andreakos, Evangelos

“…A central paradigm of immunity is that interferon (IFN)-mediated antiviral responses precede pro-inflammatory ones, optimizing host protection and minimizing…”
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Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum by Weisberg, Stuart P., Connors, Thomas J., Zhu, Yun, Baldwin, Matthew R., Lin, Wen-Hsuan, Wontakal, Sandeep, Szabo, Peter A., Wells, Steven B., Dogra, Pranay, Gray, Joshua, Idzikowski, Emma, Stelitano, Debora, Bovier, Francesca T., Davis-Porada, Julia, Matsumoto, Rei, Poon, Maya Meimei Li, Chait, Michael, Mathieu, Cyrille, Horvat, Branka, Decimo, Didier, Hudson, Krystalyn E., Zotti, Flavia Dei, Bitan, Zachary C., La Carpia, Francesca, Ferrara, Stephen A., Mace, Emily, Milner, Joshua, Moscona, Anne, Hod, Eldad, Porotto, Matteo, Farber, Donna L.

“…Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age 1 , 2 . Adults develop respiratory symptoms, which can…”
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