Search Results - "Nature cell biology"

Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis by Liu, Xiaoguang, Nie, Litong, Zhang, Yilei, Yan, Yuelong, Wang, Chao, Colic, Medina, Olszewski, Kellen, Horbath, Amber, Chen, Xiong, Lei, Guang, Mao, Chao, Wu, Shiqi, Zhuang, Li, Poyurovsky, Masha V., James You, M., Hart, Traver, Billadeau, Daniel D., Chen, Junjie, Gan, Boyi

“…SLC7A11-mediated cystine uptake suppresses ferroptosis yet promotes cell death under glucose starvation; the nature of the latter cell death remains unknown…”
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Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication by Mathieu, Mathilde, Martin-Jaular, Lorena, Lavieu, Grégory, Théry, Clotilde

“…The ability of exosomes to transfer cargo from donor to acceptor cells, thereby triggering phenotypic changes in the latter, has generated substantial interest…”
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PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis by Hou, Junwei, Zhao, Rongce, Xia, Weiya, Chang, Chiung-Wen, You, Yun, Hsu, Jung-Mao, Nie, Lei, Chen, Yeh, Wang, Yu-Chuan, Liu, Chunxiao, Wang, Wei-Jan, Wu, Yun, Ke, Baozhen, Hsu, Jennifer L., Huang, Kebin, Ye, Zu, Yang, Yi, Xia, Xianghou, Li, Yintao, Li, Chia-Wei, Shao, Bin, Tainer, John A., Hung, Mien-Chie

“…Although pyroptosis is critical for macrophages against pathogen infection, its role and mechanism in cancer cells remains unclear. PD-L1 has been detected in…”
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Cellular functions of long noncoding RNAs by Yao, Run-Wen, Wang, Yang, Chen, Ling-Ling

“…A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential, are transcribed from the mammalian genome. They are emerging as…”
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Recognition of RNA N 6 -methyladenosine by IGF2BP proteins enhances mRNA stability and translation by Huang, Huilin, Weng, Hengyou, Sun, Wenju, Qin, Xi, Shi, Hailing, Wu, Huizhe, Zhao, Boxuan Simen, Mesquita, Ana, Liu, Chang, Yuan, Celvie L, Hu, Yueh-Chiang, Hüttelmaier, Stefan, Skibbe, Jennifer R, Su, Rui, Deng, Xiaolan, Dong, Lei, Sun, Miao, Li, Chenying, Nachtergaele, Sigrid, Wang, Yungui, Hu, Chao, Ferchen, Kyle, Greis, Kenneth D, Jiang, Xi, Wei, Minjie, Qu, Lianghu, Guan, Jun-Lin, He, Chuan, Yang, Jianhua, Chen, Jianjun

“…N -methyladenosine (m A) is the most prevalent modification in eukaryotic messenger RNAs (mRNAs) and is interpreted by its readers, such as YTH…”
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Super-resolution microscopy demystified by Schermelleh, Lothar, Ferrand, Alexia, Huser, Thomas, Eggeling, Christian, Sauer, Markus, Biehlmaier, Oliver, Drummen, Gregor P. C.

“…Super-resolution microscopy (SRM) bypasses the diffraction limit, a physical barrier that restricts the optical resolution to roughly 250 nm and was previously…”
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Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization by Baccin, Chiara, Al-Sabah, Jude, Velten, Lars, Helbling, Patrick M., Grünschläger, Florian, Hernández-Malmierca, Pablo, Nombela-Arrieta, César, Steinmetz, Lars M., Trumpp, Andreas, Haas, Simon

“…The bone marrow constitutes the primary site for life-long blood production and skeletal regeneration. However, its cellular and spatial organization remains…”
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The multifaceted contributions of mitochondria to cellular metabolism by Spinelli, Jessica B., Haigis, Marcia C.

“…Although classically appreciated for their role as the powerhouse of the cell, the metabolic functions of mitochondria reach far beyond bioenergetics. In this…”
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Mechanisms of mitophagy in cellular homeostasis, physiology and pathology by Palikaras, Konstantinos, Lionaki, Eirini, Tavernarakis, Nektarios

“…Mitophagy is an evolutionarily conserved cellular process to remove dysfunctional or superfluous mitochondria, thus fine-tuning mitochondrial number and…”
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Telomere dysfunction in ageing and age-related diseases by Rossiello, Francesca, Jurk, Diana, Passos, João F., d’Adda di Fagagna, Fabrizio

“…Ageing organisms accumulate senescent cells that are thought to contribute to body dysfunction. Telomere shortening and damage are recognized causes of…”
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PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis by Zhang, Hai-Liang, Hu, Bing-Xin, Li, Zhi-Ling, Du, Tian, Shan, Jia-Lu, Ye, Zhi-Peng, Peng, Xiao-Dan, Li, Xuan, Huang, Yun, Zhu, Xian-Ying, Chen, Yu-Hong, Feng, Gong-Kan, Yang, Dajun, Deng, Rong, Zhu, Xiao-Feng

“…The accumulation of lipid peroxides is recognized as a determinant of the occurrence of ferroptosis. However, the sensors and amplifying process of lipid…”
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mTOR as a central hub of nutrient signalling and cell growth by Kim, Joungmok, Guan, Kun-Liang

“…The highly conserved protein kinase mechanistic target of rapamycin (mTOR; originally known as mammalian target of rapamycin) is a central cell growth…”
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ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway by Chu, Bo, Kon, Ning, Chen, Delin, Li, Tongyuan, Liu, Tong, Jiang, Le, Song, Shujuan, Tavana, Omid, Gu, Wei

“…It is well established that ferroptosis is primarily controlled by glutathione peroxidase 4 (GPX4). Surprisingly, we observed that p53 activation modulates…”
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5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs by Chen, Xin, Li, Ang, Sun, Bao-Fa, Yang, Ying, Han, Ya-Nan, Yuan, Xun, Chen, Ri-Xin, Wei, Wen-Su, Liu, Yanchao, Gao, Chun-Chun, Chen, Yu-Sheng, Zhang, Mengmeng, Ma, Xiao-Dan, Liu, Zhuo-Wei, Luo, Jun-Hang, Lyu, Cong, Wang, Hai-Lin, Ma, Jinbiao, Zhao, Yong-Liang, Zhou, Fang-Jian, Huang, Ying, Xie, Dan, Yang, Yun-Gui

“…Although 5-methylcytosine (m 5 C) is a widespread modification in RNAs, its regulation and biological role in pathological conditions (such as cancer) remain…”
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BAP1 links metabolic regulation of ferroptosis to tumour suppression by Zhang, Yilei, Shi, Jiejun, Liu, Xiaoguang, Feng, Li, Gong, Zihua, Koppula, Pranavi, Sirohi, Kapil, Li, Xu, Wei, Yongkun, Lee, Hyemin, Zhuang, Li, Chen, Gang, Xiao, Zhen-Dong, Hung, Mien-Chie, Chen, Junjie, Huang, Peng, Li, Wei, Gan, Boyi

“…The roles and regulatory mechanisms of ferroptosis (a non-apoptotic form of cell death) in cancer remain unclear. The tumour suppressor BRCA1-associated…”
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The lysosome as a cellular centre for signalling, metabolism and quality control by Lawrence, Rosalie E., Zoncu, Roberto

“…Long known as terminal degradation stations, lysosomes have emerged as sophisticated signalling centres that govern cell growth, division and differentiation…”
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Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells by Chen, Fei, Chen, Jianing, Yang, Linbin, Liu, Jiang, Zhang, Xiaoqian, Zhang, Yin, Tu, Qingqiang, Yin, Dong, Lin, Dechen, Wong, Ping-Pui, Huang, Di, Xing, Yue, Zhao, Jinghua, Li, Mengfeng, Liu, Qiang, Su, Fengxi, Su, Shicheng, Song, Erwei

“…Metabolic reprogramming is a hallmark of cancer. Here, we demonstrate that tumour-associated macrophages (TAMs) enhance the aerobic glycolysis and apoptotic…”
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Cargo recognition and degradation by selective autophagy by Gatica, Damián, Lahiri, Vikramjit, Klionsky, Daniel J.

“…Macroautophagy, initially described as a non-selective nutrient recycling process, is essential for the removal of multiple cellular components. In the past…”
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YAP/TAZ upstream signals and downstream responses by Totaro, Antonio, Panciera, Tito, Piccolo, Stefano

“…Cell behaviour is strongly influenced by physical, mechanical contacts between cells and their extracellular matrix. We review how the transcriptional…”
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SIRT1 is downregulated by autophagy in senescence and ageing by Xu, Caiyue, Wang, Lu, Fozouni, Parinaz, Evjen, Gry, Chandra, Vemika, Jiang, Jing, Lu, Congcong, Nicastri, Michael, Bretz, Corey, Winkler, Jeffrey D., Amaravadi, Ravi, Garcia, Benjamin A., Adams, Peter D., Ott, Melanie, Tong, Wei, Johansen, Terje, Dou, Zhixun, Berger, Shelley L.

“…SIRT1 (Sir2) is an NAD + -dependent deacetylase that plays critical roles in a broad range of biological events, including metabolism, the immune response and…”
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