Search Results - "Natt, François"

Control of the SOST Bone Enhancer by PTH Using MEF2 Transcription Factors by Leupin, Olivier, Kramer, Ina, Collette, Nicole M, Loots, Gabriela G, Natt, François, Kneissel, Michaela, Keller, Hansjoerg

“…Expression of the osteocyte‐derived bone formation inhibitor sclerostin in adult bone requires a distant enhancer. We show that MEF2 transcription factors…”
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Independent combinatorial effect of antisense oligonucleotides and RNAi‐mediated specific inhibition of the recombinant Rat P2X3 receptor by Hemmings‐Mieszczak, Maja, Dorn, Gabriele, Natt, François J., Hall, Jonathan, Wishart, William L.

“…Synthetic 21‐bp‐long short interfering RNAs (siRNA) can stimulate sequence‐specific mRNA degradation in mammalian cell cultures, a process referred to as RNA…”
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Tritium labeling of full-length small interfering RNAs by Christensen, Jesper, Natt, François, Hunziker, Jürg, Krauser, Joel, Andres, Hendrik, Swart, Piet

“…A simple procedure is described for full‐length single internal [3H]‐radiolabeling of oligonucleotides. Previous labeling strategies have been applied to large…”
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siRNA relieves chronic neuropathic pain by Dorn, Gabriele, Patel, Sadhana, Wotherspoon, Glen, Hemmings‐Mieszczak, Maja, Barclay, Jane, Natt, Francois J. C., Martin, Pierre, Bevan, Stuart, Fox, Alyson, Ganju, Pam, Wishart, William, Hall, Jonathan

“…Double stranded, short interfering RNAs (siRNA) of 21–22 nt length initiate a sequence‐specific, post‐trancriptional gene silencing in animals and plants known…”
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Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction by Natt, Francois, Di Cara, Alessandro, Pandolfi, Pier Paolo, Babcock, George F, Hall, Jonathan, Fumagalli, Stefano, Neb-Gulati, Arti, Thomas, George, Bernardi, Rosa, Schwemberger, Sandy

“…Impaired ribosome biogenesis is attributed to nucleolar disruption and diffusion of a subset of 60S ribosomal proteins, particularly ribosomal protein (rp)L11,…”
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Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34 by Gulati, Pawan, Gaspers, Lawrence D, Dann, Stephen G, Joaquin, Manel, Nobukuni, Takahiro, Natt, Francois, Kozma, Sara C, Thomas, Andrew P, Thomas, George

“…Excess levels of circulating amino acids (AAs) play a causal role in specific human pathologies, including obesity and type 2 diabetes. Moreover, obesity and…”
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Biodistribution and metabolism studies of lipid nanoparticle-formulated internally [3H]-labeled siRNA in mice by Christensen, Jesper, Litherland, Karine, Faller, Thomas, van de Kerkhof, Esther, Natt, François, Hunziker, Jürg, Boos, Julien, Beuvink, Iwan, Bowman, Keith, Baryza, Jeremy, Beverly, Mike, Vargeese, Chandra, Heudi, Olivier, Stoeckli, Markus, Krauser, Joel, Swart, Piet

“…Absorption, distribution, metabolism, and excretion properties of a small interfering RNA (siRNA) formulated in a lipid nanoparticle (LNP) vehicle were…”
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Amino Acids Mediate mTOR/Raptor Signaling through Activation of Class 3 Phosphatidylinositol 3OH-Kinase by Nobukuni, Takahiro, Joaquin, Manel, Roccio, Marta, Dann, Stephen G., Kim, So Young, Gulati, Pawan, Byfield, Maya P., Backer, Jonathan M., Natt, Francois, Bos, Johannes L., Fried J. T. Zwartkruis, Thomas, George, Schlessinger, Joseph

“…During the evolution of metazoans and the rise of systemic hormonal regulation, the insulin-controlled class 1 phosphatidylinositol 3OH-kinase (PI3K) pathway…”
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The mTOR Inhibitor RAD001 Sensitizes Tumor Cells to DNA-Damaged Induced Apoptosis through Inhibition of p21 Translation by Beuvink, Iwan, Boulay, Anne, Fumagalli, Stefano, Zilbermann, Frederic, Ruetz, Stephan, O’Reilly, Terence, Natt, Francois, Hall, Jonathan, Lane, Heidi A., Thomas, George

“…Although DNA damaging agents have revolutionized chemotherapy against solid tumors, a narrow therapeutic window combined with severe side effects has limited…”
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Design of a genome-wide siRNA library using an artificial neural network by Hall, Jonathan, Huesken, Dieter, Lange, Joerg, Mickanin, Craig, Weiler, Jan, Asselbergs, Fred, Warner, Justin, Meloon, Brian, Engel, Sharon, Rosenberg, Avi, Cohen, Dalia, Labow, Mark, Reinhardt, Mischa, Natt, François

“…The largest gene knock-down experiments performed to date have used multiple short interfering/short hairpin (si/sh)RNAs per gene. To overcome this burden for…”
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Metabolism studies of unformulated internally [3H]-labeled short interfering RNAs in mice by Christensen, Jesper, Litherland, Karine, Faller, Thomas, van de Kerkhof, Esther, Natt, François, Hunziker, Jürg, Krauser, Joel, Swart, Piet

“…Absorption, distribution, metabolism, and excretion properties of two unformulated model short interfering RNA (siRNAs) were determined using a single internal…”
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Corrigendum: Design of a genome-wide siRNA library using an artificial neural network by Huesken, Dieter, Lange, Joerg, Mickanin, Craig, Weiler, Jan, Asselbergs, Fred, Warner, Justin, Meloon, Brian, Engel, Sharon, Rosenberg, Avi, Cohen, Dalia, Labow, Mark, Reinhardt, Mischa, Natt, François, Hall, Jonathan

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Capillary Affinity Gel Electrophoresis for Combined Size- and Sequence-Dependent Separation of Oligonucleotides by Muscate, Angelika, Natt, François, Paulus, Aran, Ehrat, Markus

“…An interesting new approach to capillary affinity gel electrophoresis (CAGE) has been developed for the selective capture and separation of homopolymer and…”
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novel microarray approach reveals new tissue-specific signatures of known and predicted mammalian microRNAs by Beuvink, Iwan, Kolb, Fabrice A, Budach, Wolfgang, Garnier, Arlette, Lange, Joerg, Natt, Francois, Dengler, Uwe, Hall, Jonathan, Filipowicz, Witold, Weiler, Jan

“…Microarrays to examine the global expression levels of microRNAs (miRNAs) in a systematic in-parallel manner have become important tools to help unravel the…”
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Corrigendum: Design of a genome-wide siRNA library using an artificial neural network by Huesken, Dieter, Lange, Joerg, Mickanin, Craig, Weiler, Jan, Asselbergs, Fred, Warner, Justin, Meloon, Brian, Engel, Sharron, Rosenberg, Avi, Cohen, Dalia, Labow, Mark, Reinhardt, Mischa, Natt, François, Hall, Jonathan

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Global Down-Regulation of Gene Expression in the Brain Using RNA Interference, with Emphasis on Monoamine Transporters and GPCRs: Implications for Target Characterization in Psychiatric and Neurological Disorders by HOYER, DANIEL, THAKKER, DEEPAK R., NATT, FRANÇOIS, MAIER, RAINER, HUESKEN, DIETER, MÜLLER, MATTHIAS, FLOR, PETER, VAN DER PUTTEN, HERMAN, SCHMUTZ, MARKUS, BILBE, GRAEME, CRYAN, JOHN F.

“…RNA interference (RNAi) is a natural mechanism for regulating gene expression, which exists in plants, invertebrates, and mammals. We investigated whether…”
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Neurochemical and Behavioral Consequences of Widespread Gene Knockdown in the Adult Mouse Brain by Using Nonviral RNA Interference by Thakker, Deepak R., Natt, Francois, Hüsken, Dieter, Maier, Rainer, Müller, Matthias, van der Putten, Herman, Hoyer, Daniel, Cryan, John F., Bloom, Floyd E.

“…Gene expression analysis implicates an increasing number of novel genes in the brain as potential targets for the treatment of neurological and psychiatric…”
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Second Generation of Antisense Oligonucleotides: From Nuclease Resistance to Biological Efficacy in Animals by Karl-Heinz Altmann, Henri Sasmor, Uwe Pieles, Judy Phillipsd, Paul Nicklind, Fram;ois Natt, Marcel Miiller, Brett P.B Monia, Pierre Martina, Dieter A Hiisken, Robert Hanera, Thomas Geiger, Susan M. Freier, Doriano Fabbro, Nicholas M. Dean, Heinz E Moser

“…From efforts to improve the biophysical properties of antisense oligonucleotides by incorporating backbone- or sugar-modified nucleoside analogs,…”
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Genome-Wide Functional Analysis of Human Cell-Cycle Regulators by Mukherji, Mridul, Bell, Russell, Supekova, Lubica, Wang, Yan, Orth, Anthony P., Batalov, Serge, Miraglia, Loren, Huesken, Dieter, Lange, Joerg, Martin, Christopher, Sahasrabudhe, Sudhir, Reinhardt, Mischa, Natt, Francois, Hall, Jonathan, Mickanin, Craig, Labow, Mark, Chanda, Sumit K., Cho, Charles Y., Schultz, Peter G.

“…Human cells have evolved complex signaling networks to coordinate the cell cycle. A detailed understanding of the global regulation of this fundamental process…”
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A Novel Oxime-Derived Solid Support for the Synthesis of 3-Phosphorylated Oligonucleotides by Langenegger, Simon M., Moesch, Luzia, Natt, François, Hall, Jonathan, Häner, Robert

“…Oligonucleotides containing terminal phosphate groups serve as useful intermediates for different applications in molecular and cell biology, as well as for…”
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