Search Results - "Natsugari, Hideaki"

Photoisomerization of Sulindac and Ozagrel Hydrochloride by Vitamin B2 Catalyst Under Visible Light Irradiation by Suga, Mayuko, Makino, Kosho, Tabata, Hidetsugu, Oshitari, Tetsuta, Natsugari, Hideaki, Takahashi, Hideyo

“…Purpose Photoisomerization of the E / Z -alkene structures of drugs is a matter of concern as it could result in potency loss and adverse side effects. This…”
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Tolvaptan-Type Vasopressin Receptor Ligands: Important Role of Axial Chirality in the Active Form by Tabata, Hidetsugu, Yoneda, Tetsuya, Oshitari, Tetsuta, Takahashi, Hideyo, Natsugari, Hideaki

“…The anti and syn isomers of tolvaptan-type compounds, N-benzoyl-5-hydroxy-1-benzazepines (5a–c), were prepared in a stereocontrolled manner by biasing the…”
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Atropisomeric Properties of N‑Acyl/N‑Sulfonyl 5H‑Dibenzo[b,d]azepin-7(6H)‑ones by Namba, Takuya, Hotta, Mayuno, Tabata, Hidetsugu, Makino, Kosho, Oshitari, Tetsuta, Natsugari, Hideaki, Takahashi, Hideyo

“…The stereochemistry of N-acyl/N-sulfonyl 5H-dibenzo­[b,d]­azepin-7­(6H)-ones (I, II) was examined in detail by freezing the conformation with a methyl group at…”
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Elucidation of the Active Conformation of Antiproliferative Sulfonamides, 5N‑Arylsulfonyl-1,5-benzodiazepin-2-ones by Tabata, Hidetsugu, Funaki, Kaoru, Tasaka, Tomohiko, Oshitari, Tetsuta, Takahashi, Hideyo, Natsugari, Hideaki

“…The 5N-arylsulfonyl-1,5-benzodiazepin-2-ones with antiproliferative activity were prepared and successfully separated into the (a1 R,a2 R)- and (a1 S,a2…”
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Stereochemistry of N-Acyl-5H-dibenzo[b,d]azepin-7(6H)-ones by Chiba, Arisa, Tanaka, Ryoko, Hotta, Mayuno, Nakamura, Kayo, Makino, Kosho, Tabata, Hidetsugu, Oshitari, Tetsuta, Natsugari, Hideaki, Takahashi, Hideyo

“…The stereochemical properties of N-acyl-5H-dibenzo[b,d]azepin-7(6H)-ones (2a–c), which inhibit potassium channels in T cells, were examined by freezing their…”
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Conformational Preference of 2′-Fluoro-Substituted Acetophenone Derivatives Revealed by Through-Space 1H–19F and 13C–19F Spin–Spin Couplings by Otake, Chinatsu, Namba, Takuya, Tabata, Hidetsugu, Makino, Kosho, Hirano, Kiriko, Oshitari, Tetsuta, Natsugari, Hideaki, Kusumi, Takenori, Takahashi, Hideyo

“…The conformational properties of 2′-fluoro-substituted acetophenone derivatives were elucidated based on Hα–F and Cα–F through-space spin–spin couplings…”
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Atropisomeric Properties of N-Alkyl/Aryl 5H-Dibenz[b,f]azepines by Tanaka, Ryoko, Nabae, Ayana, Yamane, Koki, Makino, Kosho, Tabata, Hidetsugu, Oshitari, Tetsuta, Natsugari, Hideaki, Takahashi, Hideyo

“…The atropisomeric properties of N-alkyl and N-aryl 4-substituted 5H-dibenz[b,f]azepines were investigated. The N-alkylation and N-arylation of 4-Cl or 4-Me…”
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Atropisomeric Properties of 7-, 8-, and 9-Membered-Ring Dibenzolactams: Conformation, Thermal Stability, and Chemical Reactivity by Tabata, Hidetsugu, Suzuki, Hiroyuki, Akiba, Kumi, Takahashi, Hideyo, Natsugari, Hideaki

“…The atropisomeric enantiomers of 7-, 8-, and 9-membered-ring dibenzolactams were separated by using chiral HPLC, and their stereochemistries were clarified by…”
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Stereochemistry of N‑Benzoyl-5-substituted-1-benzazepines Revisited: Synthesis of the Conformationally Biased Derivatives and Revision of the Reported Structure by Tabata, Hidetsugu, Yoneda, Tetsuya, Tasaka, Tomohiko, Ito, Shigekazu, Oshitari, Tetsuta, Takahashi, Hideyo, Natsugari, Hideaki

“…The syn (aR*,5R*) and anti (aS*,5R*) diastereomers of N-benzoyl-C5-substituted-1-benzazepines originating in the chiralities at C5 and the Ar–N­(CO) axis were…”
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Atropisomerism in the Vaptan Class of Vasopressin Receptor Ligands: The Active Conformation Recognized by the Receptor by Tabata, Hidetsugu, Nakagomi, Jun, Morizono, Daisuke, Oshitari, Tetsuta, Takahashi, Hideyo, Natsugari, Hideaki

“…Latent chirality: Atropisomerism in the vaptan class of vasopressin receptor ligands with N‐benzoyl benzo‐fused seven‐membered‐ring nitrogen heterocycles was…”
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In vitro studies on nobiletin isolated from citrus plants and the bioactive metabolites, inhibitory action against gelatinase enzymatic activity and the molecular mechanisms in human retinal Müller cell line by Miyata, Yoshiki, Nagase, Terumasa, Katsura, Yoshiya, Takahashi, Hideyo, Natsugari, Hideaki, Oshitari, Tetsuta, Kosano, Hiroshi

“…Abstract Diabetic retinopathy (DR) is the most common cause of vision loss in patients with diabetes mellitus. Despite the presence of effective therapy, DR is…”
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Elucidation of the E-Amide Preference of N‑Acyl Azoles by Takahashi, Yuka, Ikeda, Hirotaka, Kanase, Yuki, Makino, Kosho, Tabata, Hidetsugu, Oshitari, Tetsuta, Inagaki, Satoshi, Otani, Yuko, Natsugari, Hideaki, Takahashi, Hideyo, Ohwada, Tomohiko

“…The conformational properties of N-acyl azoles (imidazole, pyrazole, and triazole) were examined. The N-2′,4′,6′-trichlorobenzoyl azoles were stable in…”
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Electronic effects on the amide E-/Z-preference of N-benzoyl-carbazole derivatives by Kayama, Susumu, Tani, Norihiko, Tabata, Hidetsugu, Oshitari, Tetsuta, Natsugari, Hideaki, Takahashi, Hideyo

“…[Display omitted] •Amide conformers of N-benzoylated 3/4-substituted carbazoles distributed unequally.•The ratio of the two conformers is controlled by the…”
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Isolation and Characterization of Atropisomers of Seven-Membered-Ring Benzolactams by Tabata, Hidetsugu, Wada, Naoya, Takada, Yuko, Oshitari, Tetsuta, Takahashi, Hideyo, Natsugari, Hideaki

“…The atropisomeric properties of seven-membered-ring benzolactams (7a–c and 8a) [1,5-benzodiazepin-2-one (a), 1,5-benzothiazepin-4-one (b), and…”
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Atropisomeric Properties of the Dibenzo[b,d]azepin-6-one Nucleus by Tabata, Hidetsugu, Akiba, Kumi, Lee, Shoukou, Takahashi, Hideyo, Natsugari, Hideaki

“…Dibenzo[b,d]azepin-6-ones (2a,b) were separated by chiral HPLC into the aR- and aS-atropisomers with high stereochemical stability, and methylation at C7 of 2a…”
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Active Conformation of Seven-Membered-Ring Benzolactams as New ACAT Inhibitors: Latent Chirality at N5 in the 1,5-Benzodiazepin-2-one Nucleus by Tabata, Hidetsugu, Wada, Naoya, Takada, Yuko, Nakagomi, Jun, Miike, Tomohiro, Shirahase, Hiroaki, Oshitari, Tetsuta, Takahashi, Hideyo, Natsugari, Hideaki

“…Nitrogen chirality: Potent new ACAT inhibitors with seven‐membered‐ring benzolactams as the core structures were first prepared, and the axial chirality…”
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執筆活動による薬学教育並びに薬剤師生涯教育への貢献 by 夏苅, 英昭

“…「はじめに」東京大学・薬学部で初めて薬学教育を受けてから50年以上が経つ. 企業[武田薬品工業(株)]でごく普通の医薬品の探索合成研究者として32年間(1969-2001年)を過ごした後, アカデミックの場(東京大学, 帝京大学)に移り18年間(2001-2018年)教育・研究に従事するという人生を歩んできた…”
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Elucidation of The Conformational Properties of 3-Pyridinoyl Indoles as Intermediates of Cannabimimetics by Takahashi, Hideyo, Araki, Koji, Tabata, Hidetsugu, Makino, Kosho, Ujiie, Ryohei, Sezaki, Kohei, Nakayama, Hiroshi, Oshitari, Tetsuta, Natsugari, Hideaki

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Nobiletin metabolites: Synthesis and inhibitory activity against matrix metalloproteinase-9 production by Oshitari, Tetsuta, Okuyama, Yuji, Miyata, Yoshiki, Kosano, Hiroshi, Takahashi, Hideyo, Natsugari, Hideaki

“…[Display omitted] A divergent synthesis of nobiletin metabolites was developed through highly oxygenated acetophenone derivative. We used commercially…”
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Conformation and Atropisomeric Properties of Indometacin Derivatives by Wakamatsu, Shintaro, Takahashi, Yuka, Tabata, Hidetsugu, Oshitari, Tetsuta, Tani, Norihiko, Azumaya, Isao, Katsumoto, Yukiteru, Tanaka, Takeyuki, Hosoi, Shinzo, Natsugari, Hideaki, Takahashi, Hideyo

“…The stereochemistry around the N‐benzoylated indole moiety of indometacin was studied by restricting the rotation about the NC7′ and/or C7′C1′ bond. In the…”
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