Search Results - "National Institutes of Health Intramural Sequencing Center"

Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants by Parker, Stephen C. J., Stitzel, Michael L., Taylor, D. Leland, Orozco, Jose Miguel, Erdos, Michael R., Akiyama, Jennifer A., van Bueren, Kelly Lammerts, Chines, Peter S., Narisu, Narisu, Black, Brian L., Visel, Axel, Pennacchio, Len A., Collins, Francis S.

“…Chromatin-based functional genomic analyses and genomewide association studies (GWASs) together implicate enhancers as critical elements influencing gene…”
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KLF3 and PAX6 are candidate driver genes in late-stage, MSI-hypermutated endometrioid endometrial carcinomas by Rudd, Meghan L, Hansen, Nancy F, Zhang, Xiaolu, Urick, Mary Ellen, Zhang, Suiyuan, Merino, Maria J, Mullikin, James C, Brody, Lawrence C, Bell, Daphne W

“…Endometrioid endometrial carcinomas (EECs) are the most common histological subtype of uterine cancer. Late-stage disease is an adverse prognosticator for EEC…”
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KLF3 and PAX6 are candidate driver genes in late-stage, MSI-hypermutated endometrioid endometrial carcinomas by Meghan L Rudd, Nancy F Hansen, Xiaolu Zhang, Mary Ellen Urick, Suiyuan Zhang, Maria J Merino, National Institutes of Health Intramural Sequencing Center Comparative Sequencing Program, James C Mullikin, Lawrence C Brody, Daphne W Bell

“…Endometrioid endometrial carcinomas (EECs) are the most common histological subtype of uterine cancer. Late-stage disease is an adverse prognosticator for EEC…”
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Life-history traits drive the evolutionary rates of mammalian coding and noncoding genomic elements by Nikolaev, Sergey I, Montoya-Burgos, Juan I, Popadin, Konstantin, Parand, Leila, Margulies, Elliott H, Antonarakis, Stylianos E

“…A comprehensive phylogenetic framework is indispensable for investigating the evolution of genomic features in mammals as a whole, and particularly in humans…”
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Identifying Gene Regulatory Elements by Genome-Wide Recovery of DNase Hypersensitive Sites by Crawford, Gregory E., Holt, Ingeborg E., Mullikin, James C., Tai, Denise, National Institutes of Health Intramural Sequencing Center, Green, Eric D., Wolfsberg, Tyra G., Collins, Francis S.

“…Analysis of the human genome sequence has identified ≈25, 000-30,000 protein-coding genes, but little is known about how most of these are regulated. Mapping…”
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recurrent inversion on the eutherian X chromosome by Cáceres, Mario, Sullivan, Robert T, Thomas, James W

“…Chromosomal inversions have an important role in evolution, and an increasing number of inversion polymorphisms are being identified in the human population…”
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