Search Results - "Nathanielsz, Peter"

Cost–benefit of antenatal glucocorticoid therapy: There is still much more to learn by Nathanielsz, Peter W.

“…Linked article: This is a mini commentary on Sacco et al., pp.325–333 in this issue. To view this article visit https://doi.org/10.1111/1471-0528.17316…”
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Prenatal stress: Biomarkers of brain development by Nathanielsz, Peter W.

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General review of contents by Peter Nathanielsz by Nathanielsz, Peter W.

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Resveratrol supplementation of high‐fat diet‐fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring by Zou, Tiande, Chen, Daiwen, Yang, Qiyuan, Wang, Bo, Zhu, Mei‐Jun, Nathanielsz, Peter W., Du, Min

“…Key points Maternal high‐fat diet impairs brown adipocyte function and correlates with obesity in offspring. Maternal resveratrol administration recovers…”
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Mechanisms by which maternal obesity programs offspring for obesity: evidence from animal studies by Zambrano, Elena, Nathanielsz, Peter W

“…Maternal obesity can profoundly affect offspring phenotype and predisposition to obesity and metabolic disease. Carefully controlled studies in precocial and…”
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Maternal programming by hypoxia alters the molecular composition of the oviduct of her offspring, the first pathway her grandchildren will transit: a potential novel pathway for intergenerational programming? by Nathanielsz, Peter W.

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Fetal programming of sexual development and reproductive function by Zambrano, Elena, Guzmán, Carolina, Rodríguez-González, Guadalupe L., Durand-Carbajal, Marta, Nathanielsz, Peter W.

“…•Negative maternal environment affects offspring sexual development.•Prenatal glucocorticoids exposure affects brain sexual differentiation behavior.•Fetal…”
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Why primate models matter by Phillips, Kimberley A., Bales, Karen L., Capitanio, John P., Conley, Alan, Czoty, Paul W., 't Hart, Bert A., Hopkins, William D., Hu, Shiu-Lok, Miller, Lisa A., Nader, Michael A., Nathanielsz, Peter W., Rogers, Jeffrey, Shively, Carol A., Voytko, Mary Lou

“…Research involving nonhuman primates (NHPs) has played a vital role in many of the medical and scientific advances of the past century. NHPs are used because…”
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Placental fatty acid transport across late gestation in a baboon model of intrauterine growth restriction by Chassen, Stephanie S., Ferchaud‐Roucher, Veronique, Palmer, Claire, Li, Cun, Jansson, Thomas, Nathanielsz, Peter W., Powell, Theresa L.

“…Key points Intrauterine growth restriction (IUGR) is associated with perinatal morbidity and increased risk of lifelong disease, including neurodevelopmental…”
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Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance by Chen, Yan-Ting, Yang, Qi-Yuan, Hu, Yun, Liu, Xiang-Dong, de Avila, Jeanene M., Zhu, Mei-Jun, Nathanielsz, Peter W., Du, Min

“…Maternal obesity (MO) predisposes offspring to obesity and metabolic disorders but little is known about the contribution of offspring brown adipose tissue…”
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Maternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in mice by Rosario, Fredrick J., Nathanielsz, Peter W., Powell, Theresa L., Jansson, Thomas

“…Maternal folate deficiency is linked to restricted fetal growth, however the underlying mechanisms remain to be established. Here we tested the hypothesis that…”
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Relative contributions of maternal Western‐type high fat, high sugar diets and maternal obesity to altered metabolic function in pregnancy by Zambrano, Elena, Nathanielsz, Peter W.

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Cardiac remodelling in a baboon model of intrauterine growth restriction mimics accelerated ageing by Kuo, Anderson H., Li, Cun, Li, Jinqi, Huber, Hillary F., Nathanielsz, Peter W., Clarke, Geoffrey D.

“…Key points Rodent models of intrauterine growth restriction (IUGR) successfully identify mechanisms that can lead to short‐term and long‐term detrimental…”
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Maternal obesity impairs fetal cardiomyocyte contractile function in sheep by Wang, Qiurong, Zhu, Chaoqun, Sun, Mingming, Maimaiti, Rexiati, Ford, Stephen P., Nathanielsz, Peter W., Ren, Jun, Guo, Wei

“…ABSTRACT Obesity is a major public health problem worldwide. In the United States, one‐third of women of reproductive age are obese. Human studies show that…”
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Down‐regulation of placental mTOR, insulin/IGF‐I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon by Kavitha, Jovita V., Rosario, Fredrick J., Nijland, Mark J., McDonald, Thomas J., Wu, Guoyao, Kanai, Yoshikatsu, Powell, Theresa L., Nathanielsz, Peter W., Jansson, Thomas

“…The mechanisms by which maternal nutrient restriction (MNR) causes reduced fetal growth are poorly understood. We hypothesized that MNR inhibits placental…”
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Maternal obesity epigenetically alters visceral fat progenitor cell properties in male offspring mice by Liang, Xingwei, Yang, Qiyuan, Fu, Xing, Rogers, Carl J., Wang, Bo, Pan, Hong, Zhu, Mei‐Jun, Nathanielsz, Peter W., Du, Min

“…Key points Maternal obesity reduces adipogenic progenitor density in offspring adipose tissue. The ability of adipose tissue expansion in the offspring of…”
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Maternal obesity in sheep increases fatty acid synthesis, upregulates nutrient transporters, and increases adiposity in adult male offspring after a feeding challenge by Long, Nathan M, Rule, Daniel C, Tuersunjiang, Nuermaimaiti, Nathanielsz, Peter W, Ford, Stephen P

“…Maternal obesity in women is increasing worldwide. The objective of this study was to evaluate differences in adipose tissue metabolism and function in adult…”
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Maternal obesity in the ewe increases cardiac ventricular expression of glucocorticoid receptors, proinflammatory cytokines and fibrosis in adult male offspring by Ghnenis, Adel B, Odhiambo, John F, McCormick, Richard J, Nathanielsz, Peter W, Ford, Stephen P

“…Obesity during human pregnancy predisposes offspring to obesity and cardiovascular disease in postnatal life. In a sheep model of maternal…”
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Rodent studies of developmental programming and ageing mechanisms: Special issue: In utero and early life programming of ageing and disease by Zambrano, Elena, Lomas-Soria, Consuelo, Nathanielsz, Peter W

“…Compelling evidence exists indicating that developmental programming influences ageing. Programming alters life-course phenotype in multiple organs,…”
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Primate fetal hepatic responses to maternal obesity: epigenetic signalling pathways and lipid accumulation by Puppala, Sobha, Li, Cun, Glenn, Jeremy P., Saxena, Romil, Gawrieh, Samer, Quinn, Amy, Palarczyk, Jennifer, Dick, Edward J., Nathanielsz, Peter W., Cox, Laura A.

“…Key points Maternal obesity (MO) and exposure to a high‐fat, high‐simple‐carbohydrate diet during pregnancy predisposes offspring to obesity, metabolic and…”
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