Search Results - "Nathan, DG"

Careers in Translational Clinical Research—Historical Perspectives, Future Challenges by Nathan, David G

“…A recent survey reveals that only about 11% of medical school graduates plan careers that are exclusively or significantly devoted to research. Nathan proposes…”
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Clinical Research: Perceptions, Reality, and Proposed Solutions by Nathan, David G, for the National Institutes of Health Director's Panel on Clinical Research

“…CONTEXT.— The proportion of investigators applying for clinical research grants from the National Institutes of Health (NIH) who are physicians has declined…”
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Academic Freedom in Clinical Research by Weatherall, David J, Nathan, David G

“…“Is the university–industrial complex out of control?” The editorial that appeared under this eye-catching title in Nature in January 2001 came to the…”
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Sickle cell vaso-occlusion causes activation of iNKT cells that is decreased by the adenosine A2A receptor agonist regadenoson by Field, Joshua J., Lin, Gene, Okam, Maureen M., Majerus, Elaine, Keefer, Jeffrey, Onyekwere, Onyinye, Ross, Ainsley, Campigotto, Federico, Neuberg, Donna, Linden, Joel, Nathan, David G.

“…Adenosine A2A receptor (A2AR) agonists reduce invariant natural killer T (iNKT) cell activation and decrease inflammation in sickle cell disease (SCD) mice. We…”
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Pure Red-Cell Aplasia by Nathan, D G, Sieff, C A

“…To the Editor: Handgretinger et al. (Jan. 28 issue) 1 present evidence that a clone of large granular lymphocytes induced pure red-cell aplasia by attacking…”
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Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trial by Nisbet-Brown, Eric, Olivieri, Nancy F, Giardina, Patricia J, Grady, Robert W, Neufeld, Ellis J, Séchaud, Romain, Krebs-Brown, Axel J, Anderson, Judith R, Alberti, Daniele, Sizer, Kurt C, Nathan, David G

“…Transfusional iron overload is a potentially fatal complication of the treatment of thalassaemia. We aimed to investigate short-term efficacy,…”
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The several Cs of translational clinical research by Nathan, David G.

“…Perhaps because I am a veteran of the “good old days” (they were really quite bad), young physicians who hope to become clinical investigators often ask me how…”
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Clinical Research and the NIH — A Report Card by Nathan, David G, Wilson, Jean D

“…Eight years ago, Harold E. Varmus, then the director of the National Institutes of Health (NIH), convened a panel to evaluate the status of clinical research…”
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Thalassemia: The Continued Challenge by NATHAN, DAVID G.

“…: This overview describes the history of transfusion therapy and consequent iron overload in thalassemia. It emphasizes the importance of measurement of…”
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RNA and protein evidence for haplo‐insufficiency in Diamond–Blackfan anaemia patients with RPS19 mutations by Gazda, Hanna T., Zhong, Rong, Long, Lilia, Niewiadomska, Edyta, Lipton, Jeffrey M., Ploszynska, Anna, Zaucha, Jan M., Vlachos, Adrianna, Atsidaftos, Evangelia, Viskochil, David H., Niemeyer, Charlotte M., Meerpohl, Joerg J., Rokicka‐Milewska, Roma, Pospisilova, Dagmar, Wiktor‐Jedrzejczak, W., Nathan, David G., Beggs, Alan H., Sieff, Colin A.

“…Summary The genetic basis of Diamond–Blackfan anaemia (DBA), a congenital erythroid hypoplasia that shows marked clinical heterogeneity, remains obscure…”
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A novel diagnostic screen for defects in the Fanconi anemia pathway by Shimamura, Akiko, de Oca, Rocio Montes, Svenson, John L., Haining, Nicholas, Moreau, Lisa A., Nathan, David G., D'Andrea, Alan D.

“…Fanconi anemia (FA) is an autosomal recessive chromosomal instability syndrome characterized by congenital abnormalities, progressive bone marrow failure, and…”
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Survival in Medically Treated Patients with Homozygous β-Thalassemia by Olivieri, Nancy F, Nathan, David G, MacMillan, James H, Wayne, Alan S, Liu, Peter P, McGee, Allison, Martin, Marie, Koren, Gideon, Cohen, Alan R

“…The prognosis of patients with transfusion-dependent homozygous β-thalassemia (thalassemia major) has been improved by regular transfusion and iron-chelation…”
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Educational-Debt Relief for Clinical Investigators — A Vote of Confidence by Nathan, David G

“…Programs of educational-debt relief sponsored by the National Institutes of Health (NIH) have recently been enacted as a means of recruiting and retaining…”
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Monosomy 7 and the myeloid malignancies by Nathan, David G.

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New developments in iron chelators by Cunningham, Melody J, Nathan, David G

“…PURPOSE OF REVIEWFor three decades, deferoxamine has been the only approved iron chelator. This drug has an extremely short-half life and is not orally…”
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Funding Priorities for Medical Research—Reply by Nathan, David G

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Acceptance of the 2003 John Howland Award: A journey in clinical research by NATHAN, David G

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The National Institutes of Health and clinical research: a progress report by Nathan, David G, Varmus, Harold E

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Differential Binding of Erythroid and Myeloid Progenitors to Fibroblasts and Fibronectin by Tsai, Schickwann, Patel, Vikram, Beaumont, Elisabeth, Lodish, Harvey F., Nathan, David G., Sieff, Colin A.

“…Using a novel coverslip-transfer culture technique, we recently demonstrated that primitive erythroid burst-form-ing units (BFU-E) can migrate, proliferate,…”
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The β chain of the interleukin-3 receptor functionally associates with the erythropoietin receptor by JUBINSKY, P. T, KRIJANOVSKI, O. I, NATHAN, D. G, TAVERNIER, J, SIEFF, C. A

“…Interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors share a common beta chain (beta(c)), and both cytokines enhance…”
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