Search Results - "Nathalie Beslu"

In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein by Sauvageau, Guy, Krosl, Jana, Austin, Pamela, Beslu, Nathalie, Kroon, Evert, Humphries, R Keith

“…Hematopoietic stem cells (HSCs) can self-renew extensively after transplantation. The conditions supporting their in vitro expansion are still being defined…”
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Molecular interactions involved in HOXB4-induced activation of HSC self-renewal by Beslu, Nathalie, Krosl, Jana, Laurin, Mélanie, Mayotte, Nadine, Humphries, Keith R., Sauvageau, Guy

“…HOXB4 overexpression induces unique in vivo and in vitro expansion of hemopoietic stem cells (HSCs) without causing leukemia. Very little is known about the…”
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Signal transduction by several KIT juxtamembrane domain mutations by CASTERAN, Nathalie, DE SEPULVEDA, Paulo, BESLU, Nathalie, AOUBALA, Mustapha, LETARD, Sébastien, LECOCQ, Eric, ROTTAPEL, Robert, DUBREUIL, Patrice

“…Mutations of KIT receptor tyrosine kinase are found in the majority of patients with mastocytosis and in most gastrointestinal stromal tumors. Oncogenic KIT…”
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The Competitive Nature of HOXB4-Transduced HSC Is Limited by PBX1 by Krosl, Jana, Beslu, Nathalie, Mayotte, Nadine, Humphries, R.Keith, Sauvageau, Guy

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Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin by Assouline, Sarit, Culjkovic, Biljana, Cocolakis, Eftihia, Rousseau, Caroline, Beslu, Nathalie, Amri, Abdellatif, Caplan, Stephen, Leber, Brian, Roy, Denis-Claude, Miller, Wilson H., Borden, Katherine L.B.

“…The eukaryotic translation initiation factor eIF4E is elevated in 30% of malignancies including M4/M5 subtypes of acute myeloid leukemia (AML). The oncogenic…”
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Molecular dissection of Meis1 reveals 2 domains required for leukemia induction and a key role for Hoxa gene activation by Mamo, Aline, Krosl, Jana, Kroon, Evert, Bijl, Janet, Thompson, Alexander, Mayotte, Nadine, Girard, Simon, Bisaillon, Richard, Beslu, Nathalie, Featherstone, Mark, Sauvageau, Guy

“…The Hoxa9 and Meis1 genes represent important oncogenic collaborators activated in a significant proportion of human leukemias with genetic alterations in the…”
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The Competitive Nature of HOXB4-Transduced HSC Is Limited by PBX1: The Generation of Ultra-Competitive Stem Cells Retaining Full Differentiation Potential by Krosl, Jana, Beslu, Nathalie, Mayotte, Nadine, Humphries, R.Keith, Sauvageau, Guy

“…We previously showed that HOXB4 is a potent stimulator of hematopoietic stem cell (HSC) proliferation in vivo and ex vivo. As a result, HOXB4 overexpressing…”
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Targeting the Oncogene eIF4E with Ribavirin: A Novel Therapeutic Avenue in Acute Myeloid Leukemia by Assouline, Sarit E., Cocolakis, Eftihia, Rousseau, Caroline, Culjkovic, Biljana, Beslu, Nathalie, Amri, Abdellatif, Caplan, Stephen N., Leber, Brian, Roy, Denis-Claude, Borden, Katherine L.B., Miller, Wilson H.

“…Abstract 2085 Poster Board II-62 Over the past 10 years, the incidence of acute myeloid leukemia (AML) has increased significantly with approximately 15 000…”
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Ectopic Expression of Mutated HOXB4 Proteins with Increased Intracellular Stability Affects Both Long and Short Term Hematopoietic Reconstitution by Beauchemin, Stephanie, Krosl, Gorazd, Beslu, Nathalie, Krosl, Jana, Sauvageau, Guy, Roy, Denis-Claude

“…The capacity of recombinant Hoxb4 protein to induce ex vivo expansion of HSCs identifies this protein as a potential HSC expanding factor. However, its short…”
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Phosphatidylinositol-3′ Kinase Is Not Required for Mitogenesis or Internalization of the Flt3/Flk2 Receptor Tyrosine Kinase by Beslu, Nathalie, LaRose, Jose, Casteran, Nathalie, Birnbaum, Daniel, Lecocq, Eric, Dubreuil, Patrice, Rottapel, Robert

“…Flt3/Flk2 is a receptor tyrosine kinase that is expressed on early hematopoietic progenitor cells. Flt3/Flk2 belongs to a family of receptors, including Kit…”
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Expression and signal transduction of the FLT3 tyrosine kinase receptor by Rosnet, O, Bühring, H J, deLapeyrière, O, Beslu, N, Lavagna, C, Marchetto, S, Rappold, I, Drexler, H G, Birg, F, Rottapel, R, Hannum, C, Dubreuil, P, Birnbaum, D

“…FLT3 is a receptor tyrosine kinase of 130-55 kDa expressed on normal bone marrow stem and early progenitor cells and on leukemic blasts from patients with…”
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Phosphatidylinositol-3′ Kinase Is Not Required for Mitogenesis or Internalization of the Flt3/Flk2 Receptor Tyrosine Kinase by Nathalie Beslu, Jose LaRose, Nathalie Casteran, Daniel Birnbaum, Eric Lecocq, Patrice Dubreuil, Robert Rottapel

“…Flt3/Flk2 is a receptor tyrosine kinase that is expressed on early hematopoietic progenitor cells. Flt3/Flk2 belongs to a family of receptors, including Kit…”
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