Search Results - "Nath, Raghu G."

An endogenous DNA adduct as a prognostic biomarker for hepatocarcinogenesis and its prevention by Theaphenon E in mice by Fu, Ying, Silverstein, Shana, McCutcheon, Justine N., Dyba, Marcin, Nath, Raghu G., Aggarwal, Monika, Coia, Heidi, Bai, Angela, Pan, Jishen, Jiang, Jiji, Kallakury, Bhaskar, Wang, Hongkun, Zhang, Yu‐Wen, Giaccone, Giuseppe, He, Aiwu Ruth, Chung, Fung‐Lung

“…Hepatocellular carcinoma (HCC) is the third leading cause of cancer–related deaths worldwide, mainly because of its poor prognosis. A valid mechanism‐based…”
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Detoxification: A Novel Function of BRCA1 in Tumor Suppression? by Kang, Hyo Jin, Hong, Young Bin, Kim, Hee Jeong, Rodriguez, Olga C., Nath, Raghu G., Tilli, Elena M., Albanese, Christopher, Chung, Fung-Lung, Kwon, Sang Hoon, Bae, Insoo

“…Our studies found that BRCA1 levels negatively correlate with DNA adducts induced by Benzo(a)pyrene (BaP). Pulse-chase experiments showed that the increase in…”
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Association of body burden of mercury with liver function test status in the U.S. population by Lin, Yu-Sheng, Ginsberg, Gary, Caffrey, James L., Xue, Jianping, Vulimiri, Suryanarayana V., Nath, Raghu G., Sonawane, Babasaheb

“…The majority of mercury (Hg) exposure in the US population is from consumption of fish contaminated with methylmercury (MeHg). Since inorganic Hg is the…”
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Regioselective Formation of Acrolein-Derived Cyclic 1,N 2‑Propanodeoxyguanosine Adducts Mediated by Amino Acids, Proteins, and Cell Lysates by Chung, Fung-Lung, Wu, Mona Y, Basudan, Ahmed, Dyba, Marcin, Nath, Raghu G

“…Acrolein (Acr) is a major component in cigarette smoke and a ubiquitous environmental pollutant. It is also formed as a product of lipid peroxidation…”
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Regioselective formation of acrolein-derived cyclic 1,N(2)-propanodeoxyguanosine adducts mediated by amino acids, proteins, and cell lysates by Chung, Fung-Lung, Wu, Mona Y, Basudan, Ahmed, Dyba, Marcin, Nath, Raghu G

“…Acrolein (Acr) is a major component in cigarette smoke and a ubiquitous environmental pollutant. It is also formed as a product of lipid peroxidation…”
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In vivo detection of a novel endogenous etheno–DNA adduct derived from arachidonic acid and the effects of antioxidants on its formation by Fu, Ying, Nath, Raghu G., Dyba, Marcin, Cruz, Idalia M., Pondicherry, Sharanya R., Fernandez, Aileen, Schultz, Casey L., Yang, Peiying, Pan, Jishen, Desai, Dhimant, Krzeminski, Jacek, Amin, Shantu, Christov, Plamen P., Hara, Yukihiko, Chung, Fung-Lung

“…Previous studies showed that 7-(1′,2′-dihydroxyheptyl)-substituted etheno DNA adducts are products of reactions with the epoxide of (E)-4-hydroxy-2-nonenal, an…”
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Effects of Epigallocatechin Gallate, L-Ascorbic Acid, [alpha]-Tocopherol, and Dihydrolipoic Acid on the Formation of Deoxyguanosine Adducts Derived From Lipid Peroxidation by Nath, Raghu G, Wu, Mona Y, Emami, Armaghan, Chung, Fung-Lung

“…Oxidation of polyunsaturated fatty acids (PUFAs) releases α,β-unsaturated aldehydes that modify deoxyguanosine (dG) to form cyclic 1,N...-propanodeoxyguanosine…”
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Deoxyguanosine adducts of t-4-hydroxy-2-nonenal are endogenous DNA lesions in rodents and humans: detection and potential sources by Chung, F L, Nath, R G, Ocando, J, Nishikawa, A, Zhang, L

“…t-4-Hydroxy-2-nonenal (HNE) is a free radical-mediated oxidation product of polyunsaturated fatty acids. As an electrophile, HNE readily binds to proteins and…”
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Effects of Epigallocatechin Gallate, L-Ascorbic Acid, α-Tocopherol, and Dihydrolipoic Acid on the Formation of Deoxyguanosine Adducts Derived From Lipid Peroxidation by Nath, Raghu G., Wu, Mona Y, Emami, Armaghan, Chung, Fung-Lung

“…Oxidation of polyunsaturated fatty acids (PUFAs) releases α,β-unsaturated aldehydes that modify deoxyguanosine (dG) to form cyclic 1,N 2 -propanodeoxyguanosine…”
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Lipid peroxidation as a potential endogenous source for the formation of exocyclic DNA adducts by Chung, Fung-Lung, Chen, Hauh-Jyun Candy, Nath, Raghu G.

“…A number of promutagenic exocyclic DNA adducts have recently been detected in both humans and rodents without carcinogen treatment These observations raised…”
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A novel in vitro pancreatic carcinogenesis model by Kang, Hyo Jin, Hong, Young Bin, Kim, Hee Jeong, Yi, Yong Weon, Nath, Raghu G., Chang, Young Soo, Cho, Ho-Chan, Bae, Insoo

“…Environmental factors (e.g., BaP) have been pointed out as one of the etiologies of pancreatic cancer. However, very limited experimental assays are available…”
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A solid-phase extraction/high-performance liquid chromatography-based (32)P-postlabeling method for detection of cyclic 1,N(2)-propanodeoxyguanosine adducts derived from enals by Pan, Jishen, Davis, Warren, Trushin, Neil, Amin, Shantu, Nath, Raghu G, Salem, Jr, Norman, Chung, Fung-Lung

“…The cyclic 1,N(2)-propanodeoxyguanosine (PdG) adducts are Michael addition products from reactions of deoxyguanosine (dG) with enals, including acrolein (Acr),…”
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Detection of Exocyclic 1,N2-Propanodeoxyguanosine Adducts as Common DNA Lesions in Rodents and Humans by Nath, R G, Chung, F L

“…Exocyclic adducts are unique DNA modifications resulting from binding at two sites of bases that normally are involved in hydrogen-bonding for maintaining the…”
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Detection of the acrolein-derived cyclic DNA adduct by a quantitative 32P-postlabeling/solid-phase extraction/HPLC method: Blocking its artifact formation with glutathione by Emami, Armaghan, Dyba, Marcin, Cheema, Amrita K., Pan, Jishen, Nath, Raghu G., Chung, Fung-Lung

“…Acrolein (Acr), a hazardous air pollutant, reacts readily with deoxyguanosine (dG) in DNA to produce cyclic 1, N 2-propanodeoxyguanosine adducts (Acr-dG)…”
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Polyamines stimulate the formation of mutagenic 1,N2-propanodeoxyguanosine adducts from acetaldehyde by Theruvathu, Jacob A., Jaruga, Pawel, Nath, Raghu G., Dizdaroglu, Miral, Brooks, P. J.

“…Alcoholic beverage consumption is associated with an increased risk of upper gastrointestinal cancer. Acetaldehyde (AA), the first metabolite of ethanol, is a…”
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Abstract 2738: Mechanisms of cadmium carcinogenesis by Nath, Raghu G., Sonawane, BR, Vulimiri, SV, Lin, YS

“…Cadmium is a transition metal and an ubiquitous environmental and industrial pollutant. Laboratory animal studies and epidemiological studies have shown that…”
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Effect of Glutathione Depletion on Exocyclic Adduct Levels in the Liver DNA of F344 Rats by Nath, Raghu G, Ocando, Joseph E, Richie, John P, Chung, Fung-Lung

“…The effects of glutathione (GSH) depletion on the in vivo formation of cyclic 1,N 2-propanodexoxyguanosine adducts (AdG and CdG) as background lesions in the…”
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Regioselective Formation of Acrolein-Derived Cyclic 1,N super(2)-Propanodeoxyguanosine Adducts Mediated by Amino Acids, Proteins, and Cell Lysates by Chung, Fung-Lung, Wu, Mona Y, Basudan, Ahmed, Dyba, Marcin, Nath, Raghu G

“…Acrolein (Acr) is a major component in cigarette smoke and a ubiquitous environmental pollutant. It is also formed as a product of lipid peroxidation…”
Get full text

Regioselective Formation of Acrolein-derived Cyclic 1,N2-Propanodeoxyguanosine Adducts Mediated by Amino Acids, Proteins, and Cell Lysates by Chung, Fung-Lung, Wu, Mona Y, Basudan, Ahmed, Dyba, Marcin, Nath, Raghu G.

“…Acrolein (Acr) is a major component in cigarette smoke and a ubiquitous environmental pollutant. It is also formed as a product of lipid peroxidation…”
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Detection in vivo of a Novel Endogenous Etheno DNA Adduct Derived from Arachidonic Acid and the Effects of Antioxidants on Its Formation by Fu, Ying, Nath, Raghu G., Dyba, Marcin, Cruz, Idalia M., Pondicherry, Sharanya R., Fernandez, Aileen, Schultz, Casey L., Yang, Peiying, Pan, Jishen, Desai, Dhimant, Krzeminski, Jacek, Amin, Shantu, Christov, Plamen P., Hara, Yukihiko, Chung, Fung-Lung

“…Previous studies showed that the 7-(1′,2′-dihydroxyheptyl) substituted etheno DNA adducts are products from reactions with epoxide of ( E )-4-hydroxy-2-nonenal…”
Get full text