Search Results - "Nath, Karl A."

A Proposal for a Serology-Based Approach to Membranous Nephropathy by De Vriese, An S, Glassock, Richard J, Nath, Karl A, Sethi, Sanjeev, Fervenza, Fernando C

“…Primary membranous nephropathy (MN) is an autoimmune disease mainly caused by autoantibodies against the recently discovered podocyte antigens: the M-type…”
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Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease by Belcher, John D., Chen, Chunsheng, Nguyen, Julia, Milbauer, Liming, Abdulla, Fuad, Alayash, Abdu I., Smith, Ann, Nath, Karl A., Hebbel, Robert P., Vercellotti, Gregory M.

“…Treatment of sickle cell disease (SCD) is hampered by incomplete understanding of pathways linking hemolysis to vaso-occlusion. We investigated these pathways…”
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Differentiating Primary, Genetic, and Secondary FSGS in Adults: A Clinicopathologic Approach by De Vriese, An S, Sethi, Sanjeev, Nath, Karl A, Glassock, Richard J, Fervenza, Fernando C

“…FSGS describes a renal histologic lesion with diverse causes and pathogenicities that are linked by podocyte injury and depletion. Subclasses of FSGS include…”
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In the Limelight: January 2020 by Nath, Karl A

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Mayo Clinic/Renal Pathology Society Consensus Report on Pathologic Classification, Diagnosis, and Reporting of GN by Sethi, Sanjeev, Haas, Mark, Markowitz, Glen S, D'Agati, Vivette D, Rennke, Helmut G, Jennette, J Charles, Bajema, Ingeborg M, Alpers, Charles E, Chang, Anthony, Cornell, Lynn D, Cosio, Fernando G, Fogo, Agnes B, Glassock, Richard J, Hariharan, Sundaram, Kambham, Neeraja, Lager, Donna J, Leung, Nelson, Mengel, Michael, Nath, Karl A, Roberts, Ian S, Rovin, Brad H, Seshan, Surya V, Smith, Richard J H, Walker, Patrick D, Winearls, Christopher G, Appel, Gerald B, Alexander, Mariam P, Cattran, Daniel C, Casado, Carmen Avila, Cook, H Terence, De Vriese, An S, Radhakrishnan, Jai, Racusen, Lorraine C, Ronco, Pierre, Fervenza, Fernando C

“…Renal pathologists and nephrologists met on February 20, 2015 to establish an etiology/pathogenesis-based system for classification and diagnosis of GN, with a…”
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Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction by Belcher, John D, Chen, Chunsheng, Nguyen, Julia, Abdulla, Fuad, Zhang, Ping, Nguyen, Hao, Nguyen, Phong, Killeen, Trevor, Miescher, Sylvia M, Brinkman, Nathan, Nath, Karl A, Steer, Clifford J, Vercellotti, Gregory M

“…During hemolysis, hemoglobin and heme released from red blood cells promote oxidative stress, inflammation and thrombosis. Plasma haptoglobin and hemopexin…”
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Early Onset Preeclampsia Is Associated With Glycocalyx Degradation and Reduced Microvascular Perfusion by Weissgerber, Tracey L, Garcia-Valencia, Oscar, Milic, Natasa M, Codsi, Elizabeth, Cubro, Hajrunisa, Nath, Meryl C, White, Wendy M, Nath, Karl A, Garovic, Vesna D

“…Background The endothelial glycocalyx is a vasoprotective barrier between the blood and endothelium. We hypothesized that glycocalyx degradation is present in…”
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The role of renal research in demonstrating the protective properties of heme oxygenase-1 by Nath, Karl A

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Outcomes of Arteriovenous Fistula Creation after the Fistula First Initiative by Schinstock, Carrie A, Albright, Robert C, Williams, Amy W, Dillon, John J, Bergstralh, Eric J, Jenson, Bernice M, McCarthy, James T, Nath, Karl A

“…The arteriovenous fistula (AVF) is the preferred hemodialysis access, but AVF-failure rate is high, and complications from AVF placement are rarely reported…”
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Ccl2 deficiency protects against chronic renal injury in murine renovascular hypertension by Kashyap, Sonu, Osman, Mazen, Ferguson, Christopher M., Nath, Meryl C., Roy, Bhaskar, Lien, Karen R., Nath, Karl A., Garovic, Vesna D., Lerman, Lilach O., Grande, Joseph P.

“…Inflammation plays an important role in the pathogenesis of renal and cardiovascular disease in renovascular hypertension (RVH). Ccl2 is an important mediator…”
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Urinary Extracellular Vesicles of Podocyte Origin and Renal Injury in Preeclampsia by Gilani, Sarwat I, Anderson, Ulrik Dolberg, Jayachandran, Muthuvel, Weissgerber, Tracey L, Zand, Ladan, White, Wendy M, Milic, Natasa, Suarez, Maria Lourdes Gonzalez, Vallapureddy, Rangit Reddy, Nääv, Åsa, Erlandsson, Lena, Lieske, John C, Grande, Joseph P, Nath, Karl A, Hansson, Stefan R, Garovic, Vesna D

“…Renal histologic expression of the podocyte-specific protein, nephrin, but not podocin, is reduced in preeclamptic compared with normotensive pregnancies. We…”
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Role of TLR4 signaling in the nephrotoxicity of heme and heme proteins by Nath, Karl A, Belcher, John D, Nath, Meryl C, Grande, Joseph P, Croatt, Anthony J, Ackerman, Allan W, Katusic, Zvonimir S, Vercellotti, Gregory M

“…Destabilized heme proteins release heme, and free heme is toxic. Heme is now recognized as an agonist for the Toll-like receptor-4 (TLR4) receptor. This study…”
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Hemolysis and Acute Kidney Failure by Qian, Qi, MD, Nath, Karl A., MD, Wu, Yiming, MD, Daoud, Tarek M., MD, Sethi, Sanjeev, MD, PhD

“…Deposits of iron and hemosiderosis in the kidney have been observed in diseases with intravascular hemolysis, including paroxysmal nocturnal hemoglobinuria,…”
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Identification of a Heme Activation Site on the MD-2/TLR4 Complex by Belcher, John D, Zhang, Ping, Nguyen, Julia, Kiser, Zachary M, Nath, Karl A, Hu, Jianjun, Trent, John O, Vercellotti, Gregory M

“…Myeloid differentiation factor-2 (MD-2) binds lipopolysaccharide (LPS) and initiates toll-like receptor-4 (TLR4) pro-inflammatory signaling. Heme also…”
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KLF11 deficiency enhances chemokine generation and fibrosis in murine unilateral ureteral obstruction by De Lorenzo, Silvana B, Vrieze, Alyssa M, Johnson, Ruth A, Lien, Karen R, Nath, Karl A, Garovic, Vesna D, Khazaie, Khashayarsha, Grande, Joseph P

“…Progression of virtually all forms of chronic kidney disease (CKD) is associated with activation of pro-inflammatory and pro-fibrotic signaling pathways…”
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The murine dialysis fistula model exhibits a senescence phenotype: pathobiological mechanisms and therapeutic potential by Nath, Karl A, O'Brien, Daniel R, Croatt, Anthony J, Grande, Joseph P, Ackerman, Allan W, Nath, Meryl C, Yamada, Satsuki, Terzic, Andre, Tchkonia, Tamara, Kirkland, James L, Katusic, Zvonimir S

“…There is no therapy that promotes maturation and functionality of a dialysis arteriovenous fistula (AVF). The search for such therapies largely relies on…”
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Vascular protection by tetrahydrobiopterin: progress and therapeutic prospects by Katusic, Zvonimir S, d’Uscio, Livius V, Nath, Karl A

“…Tetrahydrobiopterin (BH4) is an essential cofactor required for the activity of endothelial nitric oxide (NO) synthase. Suboptimal concentrations of BH4 in the…”
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Adeno-associated virus-9 reverses delayed gastric emptying of solids in diabetic mice by Li, Xiaojie, Ji, Sihan, Cipriani, Gianluca, Hillestad, Matthew L, Eisenman, Seth T, Barry, Michael A, Nath, Karl A, Linden, David R, Wright, Alec, AlAsfoor, Shefaa, Grover, Madhusudan, Sha, Lei, Hsi, Linda C, Farrugia, Gianrico

“…Gastroparesis is defined by delayed gastric emptying (GE) without obstruction. Studies suggest targeting heme oxygenase-1 (HO1) may ameliorate diabetic…”
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CKD Due to a Novel Mitochondrial DNA Mutation: A Case Report by Fervenza, Fernando C., Gavrilova, Ralitza H., Nasr, Samih H., Irazabal, Maria V., Nath, Karl A.

“…In human kidney disease, mitochondrial ultrastructural damage has long been recognized. Although the extent to which such mitochondrial changes contribute to…”
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Highlights from the Current Issue – Audiovisual Summary by Nath, Karl A.

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