Search Results - "Natesan, Senthilkumar A."

Genome-wide maps of recombination and chromosome segregation in human oocytes and embryos show selection for maternal recombination rates by Ottolini, Christian S, Newnham, Louise J, Capalbo, Antonio, Natesan, Senthilkumar A, Joshi, Hrishikesh A, Cimadomo, Danilo, Griffin, Darren K, Sage, Karen, Summers, Michael C, Thornhill, Alan R, Housworth, Elizabeth, Herbert, Alex D, Rienzi, Laura, Ubaldi, Filippo M, Handyside, Alan H, Hoffmann, Eva R

“…Eva Hoffman, Alan Handyside and colleagues generate genome-wide maps of crossovers and chromosome segregation patterns by recovering all three products of…”
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Generation of meiomaps of genome-wide recombination and chromosome segregation in human oocytes by Ottolini, Christian S, Capalbo, Antonio, Newnham, Louise, Cimadomo, Danilo, Natesan, Senthilkumar A, Hoffmann, Eva R, Ubaldi, Filippo M, Rienzi, Laura, Handyside, Alan H

“…This protocol describes how to perform polar body biopsy, artificial activation of human oocytes and SNP genotyping to generate genome-wide maps of female…”
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Genome-wide karyomapping accurately identifies the inheritance of single-gene defects in human preimplantation embryos in vitro by Natesan, Senthilkumar A., Bladon, Alex J., Coskun, Serdar, Qubbaj, Wafa, Prates, Renata, Munne, Santiago, Coonen, Edith, Dreesen, Joseph C.F.M., Stevens, Servi J.C., Paulussen, Aimee D.C., Stock-Myer, Sharyn E., Wilton, Leeanda J., Jaroudi, Souraya, Wells, Dagan, Brown, Anthony P.C., Handyside, Alan H.

“…Purpose: Our aim was to compare the accuracy of family- or disease-specific targeted haplotyping and direct mutation-detection strategies with the accuracy of…”
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Live birth after PGD with confirmation by a comprehensive approach (karyomapping) for simultaneous detection of monogenic and chromosomal disorders by Natesan, Senthilkumar A, Handyside, Alan H, Thornhill, Alan R, Ottolini, Christian S, Sage, Karen, Summers, Michael C, Konstantinidis, Michalis, Wells, Dagan, Griffin, Darren K

“…Abstract Preimplantation genetic diagnosis (PGD) for monogenic disorders has the drawback of time and cost associated with tailoring a specific test for each…”
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Genome-Wide Maps of Recombination and Chromosome Segregation in Human Oocytes and Embryos Show Selection for Maternal Recombination Rates by Ottolini, Christian S, Newnham, Louise J, Capalbo, Antonio, Natesan, Senthilkumar A, Joshi, Hrishikesh A, Cimadomo, Danilo, Griffin, Darren K, Sage, Karen, Summers, Michael C, Thornhill, Alan R, Housworth, Elizabeth, Herbert, Alex D, Rienzi, Laura, Ubaldi, Filippo M, Handyside, Alan H, Hoffmann, Eva R

“…ABSTRACTConservative estimates have been made that 10% to 30% of natural conceptions are aneuploid. The underlying causes are still unclear. Maternal age is…”
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Genome-wide recombination and chromosome segregation in human oocytes and embryos reveal selection for maternal recombination rates by Ottolini, Christian S., Newnham, Louise, Capalbo, Antonio, Natesan, Senthilkumar A., Joshi, Hrishikesh A., Cimadomo, Danilo, Griffin, Darren K., Sage, Karen, Summers, Michael C., Thornhill, Alan R., Housworth, Elizabeth, Herbert, Alex D., Rienzi, Laura, Ubaldi, Filippo M., Handyside, Alan H., Hoffmann, Eva R.

“…Crossover recombination reshuffles genes and prevents errors in segregation that lead to extra or missing chromosomes (aneuploidy) in human eggs, a major cause…”
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