Search Results - "Natarajan, Kathiresan"

The tubulin code at a glance by Gadadhar, Sudarshan, Bodakuntla, Satish, Natarajan, Kathiresan, Janke, Carsten

“…Microtubules are key cytoskeletal elements of all eukaryotic cells and are assembled of evolutionarily conserved α-tubulin-β-tubulin heterodimers. Despite…”
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Molecular Insights into Small‐Molecule Drug Discovery for SARS‐CoV‐2 by Su, Hailei, Zhou, Feng, Huang, Ziru, Ma, Xiaohua, Natarajan, Kathiresan, Zhang, Minchuan, Huang, Yong, Su, Haibin

“…The mainstream approach to antiviral drugs against COVID‐19 is to focus on key stages of the SARS‐CoV‐2 life cycle. The vast majority of candidates under…”
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The emerging role of the tubulin code: From the tubulin molecule to neuronal function and disease by Chakraborti, Soumyananda, Natarajan, Kathiresan, Curiel, Julian, Janke, Carsten, Liu, Judy

“…Across different cell types and tissues, microtubules are assembled from highly conserved dimers of α‐ and β‐tubulin. Despite their highly similar structures,…”
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Structural bases for stoichiometry‐selective calcium potentiation of a neuronal nicotinic receptor by Mazzaferro, Simone, Kang, Guipeun, Natarajan, Kathiresan, Hibbs, Ryan E., Sine, Steven M.

“…Background and Purpose α4β2 nicotinic acetylcholine (nACh) receptors assemble in two stoichiometric forms, one of which is potentiated by calcium. The sites of…”
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Understanding the basis of drug resistance of the mutants of αβ-tubulin dimer via molecular dynamics simulations by Natarajan, Kathiresan, Senapati, Sanjib

“…The vital role of tubulin dimer in cell division makes it an attractive drug target. Drugs that target tubulin showed significant clinical success in treating…”
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Computational screening combined with well-tempered metadynamics simulations identifies potential TMPRSS2 inhibitors by Sharanya, C. S., Wilbee, D. Sasikala, Sathi, Shijulal Nelson, Natarajan, Kathiresan

“…Type-II transmembrane serine proteases are effective pharmacological targets for host defence against viral entry and in certain cancer cell progressions…”
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Kinase activity of histone chaperone APLF maintains steady state of centrosomes in mouse embryonic stem cells by Rajam, Sruthy Manuraj, Varghese, Pallavi Chinnu, Shirude, Mayur Balkrishna, Syed, Khaja Mohieddin, Devarajan, Anjali, Natarajan, Kathiresan, Dutta, Debasree

“…Our recent studies revealed the role of mouse Aprataxin PNK-like Factor (APLF) in development. Nevertheless, the comprehensive characterization of mouse APLF…”
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Probing the Conformational Flexibility of Monomeric FtsZ in GTP-Bound, GDP-Bound, and Nucleotide-Free States by Natarajan, Kathiresan, Senapati, Sanjib

“…The mechanism of nucleotide-regulated assembly and disassembly of the prokaryotic cell division protein FtsZ is not yet clearly understood. In this work, we…”
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Mechanism of calcium potentiation of the α7 nicotinic acetylcholine receptor by Natarajan, Kathiresan, Mukhtasimova, Nuriya, Corradi, Jeremías, Lasala, Matías, Bouzat, Cecilia, Sine, Steven M

“…The α7 nicotinic acetylcholine receptor (nAChR) is among the most abundant types of nAChR in the brain, yet the ability of nerve-released ACh to activate α7…”
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TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology by Stoupa, Athanasia, Adam, Frédéric, Kariyawasam, Dulanjalee, Strassel, Catherine, Gawade, Sanjay, Szinnai, Gabor, Kauskot, Alexandre, Lasne, Dominique, Janke, Carsten, Natarajan, Kathiresan, Schmitt, Alain, Bole‐Feysot, Christine, Nitschke, Patrick, Léger, Juliane, Jabot‐Hanin, Fabienne, Tores, Frédéric, Michel, Anita, Munnich, Arnold, Besmond, Claude, Scharfmann, Raphaël, Lanza, François, Borgel, Delphine, Polak, Michel, Carré, Aurore

“…The genetic causes of congenital hypothyroidism due to thyroid dysgenesis (TD) remain largely unknown. We identified three novel TUBB1 gene mutations that…”
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Relating nucleotide-dependent conformational changes in free tubulin dimers to tubulin assembly by Natarajan, Kathiresan, Mohan, Jagan, Senapati, Sanjib

“…The complex dynamic behavior of microtubules (MTs) is believed to be primarily due to the αβ‐tubulin dimer architecture and its intrinsic GTPase activity…”
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Molecular Insights into Small‐Molecule Drug Discovery for SARS‐CoV‐2 by Su, Hailei, Zhou, Feng, Huang, Ziru, Ma, Xiaohua, Natarajan, Kathiresan, Zhang, Minchuan, Huang, Yong, Su, Haibin

“…The mainstream approach to antiviral drugs against COVID‐19 is to focus on key stages of the SARS‐CoV‐2 life cycle. The vast majority of candidates under…”
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TUBB 1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology by Stoupa, Athanasia, Adam, Frédéric, Kariyawasam, Dulanjalee, Strassel, Catherine, Gawade, Sanjay, Szinnai, Gabor, Kauskot, Alexandre, Lasne, Dominique, Janke, Carsten, Natarajan, Kathiresan, Schmitt, Alain, Bole‐Feysot, Christine, Nitschke, Patrick, Léger, Juliane, Jabot‐Hanin, Fabienne, Tores, Frédéric, Michel, Anita, Munnich, Arnold, Besmond, Claude, Scharfmann, Raphaël, Lanza, François, Borgel, Delphine, Polak, Michel, Carré, Aurore

“…The genetic causes of congenital hypothyroidism due to thyroid dysgenesis (TD) remain largely unknown. We identified three novel TUBB1 gene mutations that…”
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An essential role for α4A-tubulin in platelet biogenesis by Strassel, Catherine, Magiera, Maria M, Dupuis, Arnaud, Batzenschlager, Morgane, Hovasse, Agnès, Pleines, Irina, Guéguen, Paul, Eckly, Anita, Moog, Sylvie, Mallo, Léa, Kimmerlin, Quentin, Chappaz, Stéphane, Strub, Jean-Marc, Kathiresan, Natarajan, de la Salle, Henri, Van Dorsselaer, Alain, Ferec, Claude, Py, Jean-Yves, Gachet, Christian, Schaeffer-Reiss, Christine, Kile, Benjamin T, Janke, Carsten, Lanza, François

“…During platelet biogenesis, microtubules (MTs) are arranged into submembranous structures (the marginal band) that encircle the cell in a single plane. This…”
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Impact on AChR open channel noise by pore-peripheral salt bridge depends on voltage and divalent cations by Strikwerda, John R., Natarajan, Kathiresan, Sine, Steven M.

“…Mechanisms behind the fluctuations in the ionic current through single acetylcholine receptor (AChR) channels have remained elusive. In a recent study of…”
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Understanding the Basis of Drug Resistance of the Mutants of [alpha][beta]-Tubulin Dimer via Molecular Dynamics Simulations by Natarajan, Kathiresan, Senapati, Sanjib

“…The vital role of tubulin dimer in cell division makes it an attractive drug target. Drugs that target tubulin showed significant clinical success in treating…”
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Molecular interactions between tubulin tails and glutamylases reveal determinants of glutamylation patterns by Natarajan, Kathiresan, Gadadhar, Sudarshan, Souphron, Judith, Magiera, Maria M, Janke, Carsten

“…Posttranslational modifications of tubulin currently emerge as key regulators of microtubule functions. Polyglutamylation generates a variety of modification…”
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Discovery of small molecule entry inhibitors targeting the linoleic acid binding pocket of SARS-CoV-2 spike protein by Prasad, Roshny, Kadam, Anil, Padippurackal, Vinitha Vinod, Pulikuttymadom Balasubramanian, Aparna, Kumar Chandrakumaran, Naveen, Suresh Rangari, Kartik, Dnyaneshwar Khangar, Pawan, Ajith, Harikrishnan, Natarajan, Kathiresan, Chandramohanadas, Rajesh, Nelson-Sathi, Shijulal

“…Spike glycoprotein has a significant role in the entry of SARS-CoV-2 to host cells, which makes it a potential drug target. Continued accumulation of…”
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Mutation of the α-tubulin Tuba1a leads to straighter microtubules and perturbs neuronal migration by Belvindrah, Richard, Natarajan, Kathiresan, Shabajee, Preety, Bruel-Jungerman, Elodie, Bernard, Jennifer, Goutierre, Marie, Moutkine, Imane, Jaglin, Xavier H, Savariradjane, Mythili, Irinopoulou, Theano, Poncer, Jean-Christophe, Janke, Carsten, Francis, Fiona

“…Brain development involves extensive migration of neurons. Microtubules (MTs) are key cellular effectors of neuronal displacement that are assembled from…”
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Tyrosine phosphorylation controlled poly(A) polymerase I activity regulates general stress response in bacteria by Francis, Nimmy, Behera, Malaya R, Natarajan, Kathiresan, Laishram, Rakesh S

“…RNA 3'-end polyadenylation that marks transcripts for degradation is implicated in general stress response in Yet, the mechanism and regulation of poly(A)…”
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