Search Results - "Natanek, Samantha A."

miR‐424‐5p reduces ribosomal RNA and protein synthesis in muscle wasting by Connolly, Martin, Paul, Richard, Farre‐Garros, Roser, Natanek, Samantha A., Bloch, Susannah, Lee, Jen, Lorenzo, Jose P., Patel, Harnish, Cooper, Cyrus, Sayer, Avan A., Wort, Stephen J., Griffiths, Mark, Polkey, Michael I., Kemp, Paul R.

“…Background A loss of muscle mass occurs as a consequence of a range of chronic and acute diseases as well as in older age. This wasting results from an…”
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Phenotypic Characteristics Associated With Reduced Short Physical Performance Battery Score in COPD by Patel, Mehul S., MBBS, Mohan, Divya, MBBS, Andersson, Yvonne M., BSc, Baz, Manuel, MD, Samantha Kon, S.C., MBBS, Canavan, Jane L., PhD, Jackson, Sonya G., PhD, Clark, Amy L., BSc, Hopkinson, Nicholas S., PhD, Natanek, Samantha A., PhD, Kemp, Paul R., PhD, Bruijnzeel, Piet L.B., PhD, Man, William D.-C., PhD, Polkey, Michael I., PhD

“…Background The Short Physical Performance Battery (SPPB) is commonly used in gerontology, but its determinants have not been previously evaluated in COPD. In…”
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Quadriceps strength and endurance in fibrotic idiopathic interstitial pneumonia by Mendoza, Laura, Gogali, Athena, Shrikrishna, Dinesh, Cavada, Gabriel, Kemp, Samuel V., Natanek, Samantha A., Jackson, Abigail S., Polkey, Michael I., Wells, Athol U., Hopkinson, Nicholas S.

“…Background and objective Quadriceps muscle dysfunction is an important contributor to exercise limitation in chronic obstructive pulmonary disease, but little…”
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Increased skeletal muscle-specific microRNA in the blood of patients with COPD by Donaldson, Anna, Natanek, Samantha A, Lewis, Amy, Man, William D-C, Hopkinson, Nicholas S, Polkey, Michael I, Kemp, Paul R

“…Skeletal muscle weakness in chronic obstructive pulmonary disease (COPD) carries a poor prognosis, therefore a non-invasive marker of this process could be…”
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Skeletal muscle adiposity is associated with physical activity, exercise capacity and fibre shift in COPD by MADDOCKS, Matthew, SHRIKRISHNA, Dinesh, VITORIANO, Simone, NATANEK, Samantha A, TANNER, Rebecca J, HART, Nicholas, KEMP, Paul R, MOXHAM, John, POLKEY, Michael I, HOPKINSON, Nicholas S

“…Quadriceps muscle phenotype varies widely between patients with chronic obstructive pulmonary disease (COPD) and cannot be determined without muscle biopsy. We…”
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Downregulation of the serum response factor/miR-1 axis in the quadriceps of patients with COPD by Lewis, Amy, Riddoch-Contreras, Joanna, Natanek, Samantha A, Donaldson, Anna, Man, William D-C, Moxham, John, Hopkinson, Nicholas S, Polkey, Michael I, Kemp, Paul R

“…Muscle atrophy confers a poor prognosis in patients with chronic obstructive pulmonary disease (COPD), yet the molecular pathways responsible are poorly…”
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COPD is accompanied by co-ordinated transcriptional perturbation in the quadriceps affecting the mitochondria and extracellular matrix by Willis-Owen, Saffron A. G., Thompson, Anna, Kemp, Paul R., Polkey, Michael I., Cookson, William O. C. M., Moffatt, Miriam F., Natanek, Samantha A.

“…Skeletal muscle dysfunction is a frequent extra-pulmonary manifestation of Chronic Obstructive Pulmonary Disease (COPD) with implications for both quality of…”
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Vastus lateralis fiber shift is an independent predictor of mortality in chronic obstructive pulmonary disease by Patel, Mehul S, Natanek, Samantha A, Stratakos, Grigorios, Pascual, Sergi, Martínez-Llorens, Juana, Disano, Laura, Terzis, Gerasimos, Hopkinson, Nicholas S, Gea, Joaquim, Vogiatzis, Ioannis, Maltais, François, Polkey, Michael I

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Heterogeneity of quadriceps muscle phenotype in chronic obstructive pulmonary disease (Copd); implications for stratified medicine? by Natanek, Samantha A., Gosker, Harry R., Slot, Ilse G.M., Marsh, Gemma S., Hopkinson, Nicholas S., Man, William D.-C., Tal-Singer, Ruth, Moxham, John, Kemp, Paul R., Schols, Annemie M.W.J., Polkey, Michael I.

“…ABSTRACT Introduction Quadriceps muscle dysfunction is common in COPD. Determining, and, if possible, predicting quadriceps phenotype in COPD is important for…”
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Pathways associated with reduced quadriceps oxidative fibres and endurance in COPD by NATANEK, Samantha A, GOSKER, Harry R, SLOT, Ilse G. M, MARSH, Gemma S, HOPKINSON, Nicholas S, MOXHAM, John, KEMP, Paul R, SCHOLS, Annemie M. W. J, POLKEY, Michael I

“…Reduced quadriceps endurance in chronic obstructive pulmonary disease (COPD) is associated with a predominance of type II glycolytic fibres over type I…”
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MuRF-1 and atrogin-1 protein expression and quadriceps fiber size and muscle mass in stable patients with COPD by Natanek, Samantha A, Riddoch-Contreras, Joanna, Marsh, Gemma S, Hopkinson, Nicholas S, Moxham, John, Man, William D-C, Kemp, Paul R, Polkey, Michael I

“…Animal studies demonstrate the importance of the E3 ubiquitin ligases, Muscle RING-Finger Protein 1 (MuRF-1) and atrogin-1, in muscle protein degradation…”
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p38 mitogen-activated protein kinase is not activated in the quadriceps of patients with stable chronic obstructive pulmonary disease by Riddoch-Contreras, Joanna, George, Tomasz, Natanek, Samantha A, Marsh, Gemma S, Hopkinson, Nicholas S, Tal-Singer, Ruth, Kemp, Paul, Polkey, Michael I

“…Quadriceps weakness is associated with a poor prognosis in COPD. Several data suggest that immobility and muscle wasting may be related through up-regulation…”
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