Search Results - "Natalie R. Gassman"

Induction of oxidative stress by bisphenol A and its pleiotropic effects by Gassman, Natalie R.

“…Bisphenol A (BPA) has become a target of intense public scrutiny since concerns about its association with human diseases such as obesity, diabetes,…”
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Dihydronicotinamide riboside promotes cell-specific cytotoxicity by tipping the balance between metabolic regulation and oxidative stress by Sonavane, Manoj, Hayat, Faisal, Makarov, Mikhail, Migaud, Marie E, Gassman, Natalie R

“…Nicotinamide adenine dinucleotide (NAD+), the essential cofactor derived from vitamin B3, is both a coenzyme in redox enzymatic processes and substrate in…”
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Glucose Increases STAT3 Activation, Promoting Sustained XRCC1 Expression and Increasing DNA Repair by Wright, Griffin M, Gassman, Natalie R

“…Dysregulation of DNA repair is a hallmark of cancer, though few cancer-specific mechanisms that drive the overexpression of DNA repair proteins are known. We…”
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Activated STAT3 Is a Novel Regulator of the XRCC1 Promoter and Selectively Increases XRCC1 Protein Levels in Triple Negative Breast Cancer by Wright, Griffin, Sonavane, Manoj, Gassman, Natalie R.

“…Base Excision Repair (BER) addresses base lesions and abasic sites induced by exogenous and endogenous stressors. X-ray cross complementing group 1 (XRCC1)…”
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Defective base excision repair in the response to DNA damaging agents in triple negative breast cancer by Lee, Kevin J, Piett, Cortt G, Andrews, Joel F, Mann, Elise, Nagel, Zachary D, Gassman, Natalie R

“…DNA repair defects have been increasingly focused on as therapeutic targets. In hormone-positive breast cancer, XRCC1-deficient tumors have been identified and…”
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Dihydroxyacetone suppresses mTOR nutrient signaling and induces mitochondrial stress in liver cells by Hernandez, Arlet, Sonavane, Manoj, Smith, Kelly R, Seiger, Jensyn, Migaud, Marie E, Gassman, Natalie R

“…Dihydroxyacetone (DHA) is the active ingredient in sunless tanning products and a combustion product from e-juices in electronic cigarettes (e-cigarettes). DHA…”
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Cytoprotective Effect of Vitamin D on Doxorubicin-Induced Cardiac Toxicity in Triple Negative Breast Cancer by Lee, Kevin J, Wright, Griffin, Bryant, Hannah, Wiggins, Leigh Ann, Dal Zotto, Valeria L, Schuler, Michele, Malozzi, Christopher, Cohen, Michael V, Gassman, Natalie R

“…Doxorubicin (Dox) is a first-line treatment for triple negative breast cancer (TNBC), but its use may be limited by its cardiotoxicity mediated by the…”
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Suicidal cross-linking of PARP-1 to AP site intermediates in cells undergoing base excision repair by Prasad, Rajendra, Horton, Julie K, Chastain, 2nd, Paul D, Gassman, Natalie R, Freudenthal, Bret D, Hou, Esther W, Wilson, Samuel H

“…Poly(ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear enzyme in mammalian cells. The enzyme synthesizes polymers of ADP-ribose from the coenzyme NAD(+)…”
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Novel Techniques for Mapping DNA Damage and Repair in the Brain by Hedlich-Dwyer, Jenna, Allard, Joanne S, Mulgrave, Veronica E, Kisby, Glen E, Raber, Jacob, Gassman, Natalie R

“…DNA damage in the brain is influenced by endogenous processes and metabolism along with exogenous exposures. Accumulation of DNA damage in the brain can…”
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The Biochemical Pathways of Nicotinamide-Derived Pyridones by Hayat, Faisal, Sonavane, Manoj, Makarov, Mikhail V, Trammell, Samuel A J, McPherson, Pamela, Gassman, Natalie R, Migaud, Marie E

“…As catabolites of nicotinamide possess physiological relevance, pyridones are often included in metabolomics measurements and associated with pathological…”
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Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts by Gassman, Natalie R, Coskun, Erdem, Stefanick, Donna F, Horton, Julie K, Jaruga, Pawel, Dizdaroglu, Miral, Wilson, Samuel H

“…Bisphenol A (BPA) is a biologically active industrial chemical used in production of consumer products. BPA has become a target of intense public scrutiny…”
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Base excision repair defects invoke hypersensitivity to PARP inhibition by Horton, Julie K, Stefanick, Donna F, Prasad, Rajendra, Gassman, Natalie R, Kedar, Padmini S, Wilson, Samuel H

“…PARP-1 is important for the recognition of both endogenous and exogenous DNA damage, and binds to DNA strand breaks including intermediates of base excision…”
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Exploiting DNA repair defects in triple negative breast cancer to improve cell killing by Lee, Kevin J., Mann, Elise, Wright, Griffin, Piett, Cortt G., Nagel, Zachary D., Gassman, Natalie R.

“…Background: The lack of molecular targets for triple negative breast cancer (TNBC) has limited treatment options and reduced survivorship. Identifying new…”
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Analysis of single, cisplatin‐induced DNA bends by atomic force microscopy and simulations by Dutta, Samrat, Rivetti, Claudio, Gassman, Natalie R., Young, Carl G., Jones, Bradley T., Scarpinato, Karin, Guthold, Martin

“…Bent DNA, or DNA that is locally more flexible, is a recognition motif for many DNA binding proteins. These DNA conformational properties can thus influence…”
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XRCC1 phosphorylation affects aprataxin recruitment and DNA deadenylation activity by Horton, Julie K., Stefanick, Donna F., Çağlayan, Melike, Zhao, Ming-Lang, Janoshazi, Agnes K., Prasad, Rajendra, Gassman, Natalie R., Wilson, Samuel H.

“…•Phosphorylation of XRCC1 critical for its interaction with the FHA domain of APTX.•Expression of XRCC1 phosphorylation mutant designed to eliminate APTX…”
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Nuclear Localization of the DNA Repair Scaffold XRCC1: Uncovering the Functional Role of a Bipartite NLS by Kirby, Thomas W., Gassman, Natalie R., Smith, Cassandra E., Pedersen, Lars C., Gabel, Scott A., Sobhany, Mack, Wilson, Samuel H., London, Robert E.

“…We have characterized the nuclear localization signal (NLS) of XRCC1 structurally using X-ray crystallography and functionally using fluorescence imaging…”
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XRCC1-mediated repair of strand breaks independent of PNKP binding by Horton, Julie K., Stefanick, Donna F., Zhao, Ming-Lang, Janoshazi, Agnes K., Gassman, Natalie R., Seddon, Hannah J., Wilson, Samuel H.

“…•End cleaning activities of PNKP facilitated by binding to phosphorylated XRCC1.•Expression of XRCC1 phosphorylation mutant designed to eliminate PNKP…”
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Intentional tanning behaviors among undergraduates on the United States' Gulf Coast by Daniel, Casey L, Gassman, Natalie R, Fernandez, Alyssa M, Bae, Sejong, Tan, Marcus C B

“…Rates of melanoma have dramatically increased among adolescents and young adults in recent years, particularly among young women. Exposure to ultraviolet…”
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From single-molecule to genome-wide mapping of DNA lesions: repair-assisted damage detection sequencing by Gilat, Noa, Fridman, Dena, Sharim, Hila, Margalit, Sapir, Gassman, Natalie R., Michaeli, Yael, Ebenstein, Yuval

“…Mapping DNA damage and its repair has immense potential in understanding environmental exposures, their genotoxicity, and their impact on human health…”
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Newcastle Disease Virus Induces Profound Lymphoid Depletion with Different Patterns of Necroptosis, Necrosis, and Oxidative DNA Damage in Bursa, Spleen, and Other Lymphoid Tissues by Rabiei, Mohammad, McAllister, Milton M, Gassman, Natalie R, Lee, Kevin J, Acton, Sydney, Liebhart, Dieter, Low, Wai Yee, Hemmatzadeh, Farhid

“…This study delves into the pathogenesis of virulent genotype VII strains of the Newcastle disease virus (NDV), focusing on experimentally infected birds…”
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