Search Results - "Natalie C. J. Strynadka"

X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation by Lee, Jaeyong, Kenward, Calem, Worrall, Liam J., Vuckovic, Marija, Gentile, Francesco, Ton, Anh-Tien, Ng, Myles, Cherkasov, Artem, Strynadka, Natalie C. J., Paetzel, Mark

“…Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the pathogen that causes COVID-19, produces polyproteins 1a and 1ab that contain, respectively,…”
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Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry by Majewski, Dorothy D., Worrall, Liam J., Hong, Chuan, Atkinson, Claire E., Vuckovic, Marija, Watanabe, Nobuhiko, Yu, Zhiheng, Strynadka, Natalie C. J.

“…Many Gram-negative bacteria, including causative agents of dysentery, plague, and typhoid fever, rely on a type III secretion system – a multi-membrane…”
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Aligning the Symmetry of the Type III Secretion System Needle Complex by Worrall, Liam J, Hu, Jinhong, Strynadka, Natalie C. J

“…Advances in cryo-EM single-particle analysis have resulted in the routine determination of molecular structures to resolutions rivalling X-ray crystallography…”
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Structural insight into YcbB-mediated beta-lactam resistance in Escherichia coli by Caveney, Nathanael A., Caballero, Guillermo, Voedts, Henri, Niciforovic, Ana, Worrall, Liam J., Vuckovic, Marija, Fonvielle, Matthieu, Hugonnet, Jean-Emmanuel, Arthur, Michel, Strynadka, Natalie C. J.

“…The bacterial cell wall plays a crucial role in viability and is an important drug target. In Escherichia coli , the peptidoglycan crosslinking reaction to…”
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CryoEM structure of the antibacterial target PBP1b at 3.3 Å resolution by Caveney, Nathanael A., Workman, Sean D., Yan, Rui, Atkinson, Claire E., Yu, Zhiheng, Strynadka, Natalie C. J.

“…The pathway for the biosynthesis of the bacterial cell wall is one of the most prolific antibiotic targets, exemplified by the widespread use of β-lactam…”
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High-Level Resistance of Staphylococcus aureus to β-Lactam Antibiotics Mediated by Penicillin-Binding Protein 4 (PBP4) by Hamilton, Stephanie M, Alexander, J Andrew N, Choo, Eun Ju, Basuino, Li, da Costa, Thaina M, Severin, Anatoly, Chung, Marilyn, Aedo, Sandra, Strynadka, Natalie C J, Tomasz, Alexander, Chatterjee, Som S, Chambers, Henry F

“…Penicillin-binding protein 4 (PBP4), a nonessential, low-molecular-weight penicillin-binding protein of , has been implicated in low-level resistance to…”
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Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase by Farha, Maya A., Czarny, Tomasz L., Myers, Cullen L., Worrall, Liam J., French, Shawn, Conrady, Deborah G., Wang, Yang, Oldfield, Eric, Strynadka, Natalie C. J., Brown, Eric D.

“…Drug combinations are valuable tools for studying biological systems. Although much attention has been given to synergistic interactions in revealing…”
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Structural Insight into the Transglycosylation Step of Bacterial Cell-Wall Biosynthesis by Lovering, Andrew L, de Castro, Liza H, Lim, Daniel, Strynadka, Natalie C.J

“…Peptidoglycan glycosyltransferases (GTs) catalyze the polymerization step of cell-wall biosynthesis, are membrane-bound, and are highly conserved across all…”
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Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS by Zarivach, Raz, Felise, Heather B, Finlay, B. Brett, Nguyen, Hai V, Strynadka, Natalie C. J, Deng, Wanyin, Vuckovic, Marija, Miller, Samuel I

“…During infection by Gram-negative pathogenic bacteria, the type III secretion system (T3SS) is assembled to allow for the direct transmission of bacterial…”
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A refined model of the prototypical Salmonella SPI-1 T3SS basal body reveals the molecular basis for its assembly by Bergeron, Julien R C, Worrall, Liam J, Sgourakis, Nikolaos G, DiMaio, Frank, Pfuetzner, Richard A, Felise, Heather B, Vuckovic, Marija, Yu, Angel C, Miller, Samuel I, Baker, David, Strynadka, Natalie C J

“…The T3SS injectisome is a syringe-shaped macromolecular assembly found in pathogenic Gram-negative bacteria that allows for the direct delivery of virulence…”
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Assembly, structure, function and regulation of type III secretion systems by Deng, Wanyin, Marshall, Natalie C., Rowland, Jennifer L., McCoy, James M., Worrall, Liam J., Santos, Andrew S., Strynadka, Natalie C. J., Finlay, B. Brett

“…Key Points Type III secretion systems (T3SSs) are protein transport nanomachines that are used by numerous important Gram-negative bacterial pathogens and…”
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Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site by Lee, Jaeyong, Worrall, Liam J., Vuckovic, Marija, Rosell, Federico I., Gentile, Francesco, Ton, Anh-Tien, Caveney, Nathanael A., Ban, Fuqiang, Cherkasov, Artem, Paetzel, Mark, Strynadka, Natalie C. J.

“…Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the pathogen that causes the disease COVID-19, produces replicase polyproteins 1a and 1ab that…”
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Crystal structure of the C‐terminal domain of the Salmonella type III secretion system export apparatus protein InvA by Worrall, Liam J., Vuckovic, Marija, Strynadka, Natalie C. J.

“…InvA is a prominent inner‐membrane component of the Salmonella type III secretion system (T3SS) apparatus, which is responsible for regulating virulence…”
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Structural characterization of the molecular platform for type III secretion system assembly by Strynadka, Natalie C. J, Yip, Calvin K, Kimbrough, Tyler G, Felise, Heather B, Vuckovic, Marija, Thomas, Nikhil A, Pfuetzner, Richard A, Frey, Elizabeth A, Brett Finlay, B, Miller, Samuel I

“…Type III secretion systems (TTSSs) are multi-protein macromolecular 'machines' that have a central function in the virulence of many Gram-negative pathogens by…”
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New Delhi Metallo-β-Lactamase: Structural Insights into β-Lactam Recognition and Inhibition by King, Dustin T, Worrall, Liam J, Gruninger, Robert, Strynadka, Natalie C. J

“…The β-lactam antibiotics have long been a cornerstone for the treatment of bacterial disease. Recently, a readily transferable antibiotic resistance factor…”
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EscE and EscG Are Cochaperones for the Type III Needle Protein EscF of Enteropathogenic Escherichia coli by Sal-Man, Neta, Setiaputra, Dheva, Scholz, Roland, Deng, Wanyin, Yu, Angel C. Y, Strynadka, Natalie C. J, Finlay, B. Brett

“…Type III secretion systems (T3SSs) are central virulence mechanisms used by a variety of Gram-negative bacteria to inject effector proteins into host cells…”
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CesT is a multi‐effector chaperone and recruitment factor required for the efficient type III secretion of both LEE‐ and non‐LEE‐encoded effectors of enteropathogenic Escherichia coli by Thomas, Nikhil A., Deng, Wanyin, Puente, Jose L., Frey, Elizabeth A., Yip, Calvin K., Strynadka, Natalie C. J., Finlay, B. Brett

“…Summary Enteropathogenic Escherichia coli (EPEC) is an intestinal attaching and effacing pathogen that utilizes a type III secretion system (T3SS) for the…”
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Crystal structure of an intramembranal phosphatase central to bacterial cell-wall peptidoglycan biosynthesis and lipid recycling by Workman, Sean D., Worrall, Liam J., Strynadka, Natalie C. J.

“…Undecaprenyl pyrophosphate phosphatase (UppP) is an integral membrane protein that recycles the lipid carrier essential to the ongoing biosynthesis of the…”
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The Crystal Structure of MexR from Pseudomonas aeruginosa in Complex with Its Antirepressor Armr by Wilke, Mark S., Heller, Markus, Creagh, A. Louise, Haynes, Charles A., McIntosh, Lawrence P., Poole, Keith, Strynadka, Natalie C. J.

“…The intrinsic antimicrobial resistance of the opportunistic human pathogen Pseudomonas aeruginosa is compounded in mutant strains that overexpress multidrug…”
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One ring to rule them all: Current trends in combating bacterial resistance to the β‐lactams by King, Dustin T., Sobhanifar, Solmaz, Strynadka, Natalie C. J.

“…From humble beginnings of a contaminated petri dish, β‐lactam antibiotics have distinguished themselves among some of the most powerful drugs in human history…”
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