Search Results - "Natala, Srinivasa"

NPT520-34 improves neuropathology and motor deficits in a transgenic mouse model of Parkinson's disease by Khan, Asma, Johnson, Robert, Wittmer, Carrie, Maile, Michelle, Tatsukawa, Keith, Wong, Julian L, Gill, Martin B, Stocking, Emily M, Natala, Srinivasa R, Paulino, Amy D, Bowden-Verhoek, Jon K, Wrasidlo, Wolfgang, Masliah, Eliezer, Bonhaus, Douglas W, Price, Diana L

“…NPT520-34 is a clinical stage, small molecule being developed for the treatment of Parkinson's disease and other neurodegenerative disorders. The therapeutic…”
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Structure-based design and SAR development of 5,6-dihydroimidazolo[1,5-f]pteridine derivatives as novel Polo-like kinase-1 inhibitors by Kiryanov, Andre, Natala, Srinivasa, Jones, Benjamin, McBride, Christopher, Feher, Victoria, Lam, Betty, Liu, Yan, Honda, Kouhei, Uchiyama, Noriko, Kawamoto, Tomohiro, Hikichi, Yuichi, Zhang, Lilly, Hosfield, David, Skene, Robert, Zou, Hua, Stafford, Jeffrey, Cao, Xiaodong, Ichikawa, Takashi

“…[Display omitted] Using structure-based drug design, we identified a novel series of 5,6-dihydroimidazolo[1,5-f]pteridine PLK1 inhibitors. Rational…”
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Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1) by Nie, Zhe, Feher, Victoria, Natala, Srinivasa, McBride, Christopher, Kiryanov, Andre, Jones, Benjamin, Lam, Betty, Liu, Yan, Kaldor, Stephen, Stafford, Jeffrey, Hikami, Kouki, Uchiyama, Noriko, Kawamoto, Tomohiro, Hikichi, Yuichi, Matsumoto, Shin-ichi, Amano, Nobuyuki, Zhang, Lilly, Hosfield, David, Skene, Robert, Zou, Hua, Cao, Xiaodong, Ichikawa, Takashi

“…Using structure-based drug design, we identified and optimized a novel series of pyrimidodiazepinone PLK1 inhibitors resulting in the selection of the…”
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Synthesis of new coumarin 3-( N-aryl) sulfonamides and their anticancer activity by Reddy, Natala Srinivasa, Mallireddigari, Muralidhar Reddy, Cosenza, Stephen, Gumireddy, Kiranmai, Bell, Stanley C, Reddy, E.Premkumar, Reddy, M.V.Ramana

“…Synthesis of novel coumarin-3-sulfonamides and their ability to activate JNK1 and kill cancer cells in vitro is described. Synthesis of coumarin 3-( N-aryl)…”
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NPT1220-312, a TLR2/TLR9 Small Molecule Antagonist, Inhibits Pro-Inflammatory Signaling, Cytokine Release, and NLRP3 Inflammasome Activation by Habas, Agata, Reddy Natala, Srinivasa, Bowden-Verhoek, Jon K., Stocking, Emily M., Price, Diana L., Wrasidlo, Wolfgang, Bonhaus, Douglas W., Gill, Martin B.

“…Toll-like receptors (TLRs) play a critical role in innate immune system responses to damage-associated molecular patterns (DAMPs) and pathogen-associated…”
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Anti-HIV Active Petrosins from the Marine Sponge Petrosia similis by Goud, Thirumani Venkateshwar, Reddy, Natala Srinivasa, Swamy, Navath Raghavendra, Ram, Tejomoortula Siva, Venkateswarlu, Yenamandra

“…A marine sponge Petrosia similis afforded two compounds which belongs to bis-quinolizidine alkaloids namely, petrosin (1) and petrosin-A (2), respectively…”
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Novel coumarin-3-( N-aryl)carboxamides arrest breast cancer cell growth by inhibiting ErbB-2 and ERK1 by Reddy, Natala Srinivasa, Gumireddy, Kiranmai, Mallireddigari, Muralidhar R., Cosenza, Stephen C., Venkatapuram, Padmavathi, Bell, Stanley C., Reddy, E. Premkumar, Reddy, M.V. Ramana

“…The synthesis of a series of new coumarin-3( N-aryl)carboxamides and their cytotoxic and in vitro kinase inhibition activities are presented. A series of novel…”
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Structure based design and synthesis of novel Toll-like Receptor 2 (TLR 2) lipid antagonists by Natala, Srinivasa Reddy, Habas, Agata, Stocking, Emily M., Orry, Andrew, Price, Diana L., Gill, Martin B., Bonhaus, Douglas W., Abagyan, Ruben, Wrasidlo, Wolfgang

“…[Display omitted] Toll-like receptors (TLRs) play key role in innate immune response to Damage Associated Molecular Patterns (DAMPs) and Pathogen Associated…”
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Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK) by Lam, Betty, Arikawa, Yasuyoshi, Cramlett, Joshua, Dong, Qing, de Jong, Ron, Feher, Victoria, Grimshaw, Charles E., Farrell, Pamela J., Hoffman, Isaac D., Jennings, Andy, Jones, Benjamin, Matuszkiewicz, Jennifer, Miura, Joanne, Miyake, Hiroshi, Natala, Srinivasa Reddy, Shi, Lihong, Takahashi, Masashi, Taylor, Ewan, Wyrick, Corey, Yano, Jason, Zalevsky, Jonathan, Nie, Zhe

“…[Display omitted] Spleen Tyrosine Kinase (SYK) is a non-receptor cytoplasmic tyrosine kinase that is primarily expressed in hematopoietic cells. SYK is a key…”
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Anti-HIV Active Petrosins from the Marine Sponge Petrosia similis1 by Venkateshwar Goud, Thirumani, Srinivasa Reddy, Natala, Raghavendra Swamy, Navath, Siva Ram, Tejomoortula, Venkateswarlu, Yenamandra

“…A marine sponge Petrosia similis afforded two compounds which belongs to bis-quinolizidine alkaloids namely, petrosin (1) and petrosin-A (2), respectively…”
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TRTH-03. CYTO-MITO™ - A NOVEL CLASS OF DUAL-ACTING HSP90 INHIBITORS FOR THE TREATMENT OF GLIOBLASTOMA by Natala, Srinivasa Reddy, Siddique, Shyama, Carney, David, Mladek, Ann, Stebbins, Jeffrey, Yang, Li, Lee, Pooi San, Brimberry, Daniel, Ardecky, Robert, Teriete, Peter, Rubenstein, Allan, Sarkaria, Jann, Cosford, Nicholas, Prasad, Sridhar

“…Glioblastoma (GBM) is a highly invasive and aggressive primary brain tumor and is considered one of the deadliest forms of cancer. Despite aggressive…”
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A Novel Stereoselective Total Synthesis of ( )-5-epi-Cytoxazone 1 by Swamy, Navath Raghavendra, Krishnaiah, Pendem, Reddy, Natala Srinivasa, Venkateswarlu, Yenamandra

“…Stereoselective synthesis of a potent cytokine modulator cytoxazone isomer has been achieved from 2,3-O-isopropylidene D-glyceraldehyde involving Grignard…”
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A Novel Stereoselective Total Synthesis of (+)-5-epi-Cytoxazone by Swamy, Navath Raghavendra, Krishnaiah, Pendem, Reddy, Natala Srinivasa, Venkateswarlu, Yenamandra

“…Stereoselective synthesis of a potent cytokine modulator cytoxazone isomer has been achieved from 2,3-O-isopropylidene D-glyceraldehyde involving Grignard…”
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