Search Results - "Nasu, Hatsumi"

CS-8958, a Prodrug of the New Neuraminidase Inhibitor R-125489, Shows Long-Acting Anti-Influenza Virus Activity by YAMASHITA, Makoto, TOMOZAWA, Takanori, KAKUTA, Masayo, TOKUMITSU, Akane, NASU, Hatsumi, KUBO, Shuku

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In Vivo Pharmacodynamic Activity of Tomopenem (formerly CS-023) against Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus in a Murine Thigh Infection Model by SUGIHARA, Kiyoshi, SUGIHARA, Chika, KOGA, Tetsufumi, MATSUSHITA, Yoko, YAMAMURA, Naotoshi, UEMORI, Mitsutoshi, TOKUMITSU, Akane, INOUE, Harumi, KAKUTA, Masayo, NAMBA, Eiko, NASU, Hatsumi

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Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P3-sparing S1P1 agonists by Asano, Masayoshi, Nakamura, Tsuyoshi, Sekiguchi, Yukiko, Mizuno, Yumiko, Yamaguchi, Takahiro, Tamaki, Kazuhiko, Shimozato, Takaichi, Doi-Komuro, Hiromi, Kagari, Takashi, Tomisato, Wataru, Inoue, Ryotaku, Yuita, Hiroshi, Oguchi-Oshima, Keiko, Kaneko, Reina, Nara, Futoshi, Kawase, Yumi, Masubuchi, Noriko, Nakayama, Shintaro, Koga, Tetsufumi, Namba, Eiko, Nasu, Hatsumi, Nishi, Takahide

“…A series of 1,3-thiazole derivatives were synthesized as potent, orally bioavailable S1P3-sparing S1P1 agonists. One of them, 24c, exhibited favorable efficacy…”
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Filamentous phage associated with recent pandemic strains of Vibrio parahaemolyticus by Iida, T, Hattori, A, Tagomori, K, Nasu, H, Naim, R, Honda, T

“…A group of pandemic strains of Vibrio parahaemolyticus has recently appeared in Asia and North America. We demonstrate that a filamentous phage is specifically…”
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Filamentous Bacteriophages of Vibrios Are Integrated into the dif-Like Site of the Host Chromosome by Iida, Tetsuya, Makino, Kozo, Nasu, Hatsumi, Yokoyama, Katsushi, Tagomori, Kenichi, Hattori, Akiko, Okuno, Toshihiro, Shinagawa, Hideo, Honda, Takeshi

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mkp-1 Encoding Mitogen-Activated Protein Kinase Phosphatase 1, a Verotoxin 1 Responsive Gene, Detected by Differential Display Reverse Transcription-PCR in Caco-2 Cells by KOJIMA, S, YANAGIHARA, I, KONO, G, SUGAHARA, T, NASU, H, KIJIMA, M, HATTORI, A, KODAMA, T, NAGAYAMA, K.-I, HONDA, T

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A protein scaffold, engineered SPINK2, for generation of inhibitors with high affinity and specificity against target proteases by Nishimiya, Daisuke, Kawaguchi, Yoshirou, Kodama, Shiho, Nasu, Hatsumi, Yano, Hidenori, Yamaguchi, Aya, Tamura, Masakazu, Hashimoto, Ryuji

“…Proteases are one of attractive therapeutic targets to play key roles in pharmacological action. There are many protease inhibitors in nature, and most of them…”
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Construction of the control system of target molecule expression in Escherichia coli: application to a validation platform for bactericidal and bacteriostatic profiles due to suppression of a target molecule by Yoshida, Tatsuhiko, Nasu, Hatsumi, Yamashita, Makoto

“…Abstract Validation of bactericidal profiles owing to a deficiency of target bacterial molecule provides opportunities to discover antimicrobial drug…”
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A Filamentous Phage Associated with Recent PandemicVibrio parahaemolyticus O3:K6 Strains by Nasu, Hatsumi, Iida, Tetsuya, Sugahara, Tomomi, Yamaichi, Yoshiharu, Park, Kwon-Sam, Yokoyama, Katsushi, Makino, Kozo, Shinagawa, Hideo, Honda, Takeshi

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Discovery of a compound which acts as a bacterial UMP kinase PyrH inhibitor by Yoshida, Tatsuhiko, Nasu, Hatsumi, Namba, Eiko, Ubukata, Osamu, Yamashita, Makoto

“…Abstract PyrH is a member of the UMP kinase family that catalyses the conversion of UMP to UDP, an essential step in the pyrimidine metabolic pathway in a…”
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Discovery of a compound that acts as a bacterial PyrG (CTP synthase) inhibitor by YOSHIDA, Tatsuhiko, NASU, Hatsumi, NAMBA, Eiko, UBUKATA, Osamu, YAMASHITA, Makoto

“…PyrG (CTP synthase) catalyses the conversion of UTP to CTP, an essential step in the pyrimidine metabolic pathway in a variety of bacteria, including those…”
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Absorption, elimination, and metabolism of CS-1036, a novel α-amylase inhibitor in rats and monkeys, and the relationship between gastrointestinal distribution and suppression of glucose absorption by Honda, Tomohiro, Kaneno-Urasaki, Yoko, Murai, Takahiro, Kakuta, Masayo, Nasu, Hatsumi, Namba, Eiko, Koga, Tetsufumi, Okuno, Akira, Izumi, Takashi

“…The absorption, metabolism, and excretion of (2R,3R,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidin-3-yl 4-O-(6-deoxy-β-d-glucopyranosyl)-α-d-glucopyranoside…”
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A filamentous phage associated with recent pandemic Vibrio parahaemolyticus O3 : K6 strains by NASU, H, IIDA, T, SUGAHARA, T, YAMAICHI, Y, PARK, K.-S, YOKOYAMA, K, MAKINO, K, SHINAGAWA, H, HONDA, T

“…A specific serotype, O3:K6, of Vibrio parahaemolyticus has recently been causing epidemics of gastroenteritis in Southeast Asia, Japan, and North America. To…”
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