Search Results - "Nastouli, Eleni"

Nosocomial Transmission of Coronavirus Disease 2019: A Retrospective Study of 66 Hospital-acquired Cases in a London Teaching Hospital by Rickman, Hannah M, Rampling, Tommy, Shaw, Karen, Martinez-Garcia, Gema, Hail, Leila, Coen, Pietro, Shahmanesh, Maryam, Shin, Gee Yen, Nastouli, Eleni, Houlihan, Catherine F

“…Abstract Coronavirus disease 2019 (COVID-19) can cause deadly healthcare-associated outbreaks. In a major London teaching hospital, 66 of 435 (15%) COVID-19…”
Get full text

Tocilizumab in COVID-19: a meta-analysis, trial sequential analysis, and meta-regression of randomized-controlled trials by Snow, Timothy Arthur Chandos, Saleem, Naveed, Ambler, Gareth, Nastouli, Eleni, Singer, Mervyn, Arulkumaran, Nishkantha

“…Purpose Interleukin-6 (IL-6) levels discriminate between patients with mild and severe COVID-19, making IL-6 inhibition an attractive therapeutic strategy. We…”
Get full text

HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation by Gupta, Ravindra K., Abdul-Jawad, Sultan, McCoy, Laura E., Mok, Hoi Ping, Peppa, Dimitra, Salgado, Maria, Martinez-Picado, Javier, Nijhuis, Monique, Wensing, Annemarie M. J., Lee, Helen, Grant, Paul, Nastouli, Eleni, Lambert, Jonathan, Pace, Matthew, Salasc, Fanny, Monit, Christopher, Innes, Andrew J., Muir, Luke, Waters, Laura, Frater, John, Lever, Andrew M. L., Edwards, Simon G., Gabriel, Ian H., Olavarria, Eduardo

“…A cure for HIV-1 remains unattainable as only one case has been reported, a decade ago 1 , 2 . The individual—who is known as the ‘Berlin patient’—underwent…”
Get full text

The effect of spike mutations on SARS-CoV-2 neutralization by Rees-Spear, Chloe, Muir, Luke, Griffith, Sarah A., Heaney, Judith, Aldon, Yoann, Snitselaar, Jonne L., Thomas, Peter, Graham, Carl, Seow, Jeffrey, Lee, Nayung, Rosa, Annachiara, Roustan, Chloe, Houlihan, Catherine F., Sanders, Rogier W., Gupta, Ravindra K., Cherepanov, Peter, Stauss, Hans J., Nastouli, Eleni, Doores, Katie J., van Gils, Marit J., McCoy, Laura E.

“…Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines show protective efficacy, which is most likely mediated by neutralizing…”
Get full text

IVA: accurate de novo assembly of RNA virus genomes by Hunt, Martin, Gall, Astrid, Ong, Swee Hoe, Brener, Jacqui, Ferns, Bridget, Goulder, Philip, Nastouli, Eleni, Keane, Jacqueline A, Kellam, Paul, Otto, Thomas D

“…An accurate genome assembly from short read sequencing data is critical for downstream analysis, for example allowing investigation of variants within a…”
Get full text

Assessing spatiotemporal variability in SARS-CoV-2 infection risk for hospital workers using routinely-collected data by Wilson-Aggarwal, Jared K, Gotts, Nick, Arnold, Kellyn, Spyer, Moira J, Houlihan, Catherine F, Nastouli, Eleni, Manley, Ed

“…The COVID-19 pandemic has emphasised the need to rapidly assess infection risks for healthcare workers within the hospital environment. Using data from the…”
Get full text

Editorial: Bridging the gap between immunology, virology, genetics, and epigenetics in bronchiolitis: The multiomics pathway to asthma development by Makrinioti, Heidi, Morita, Hideaki, Nastouli, Eleni, Jartti, Tuomas

Get full text

Comparative Study of Sensitivity, Linearity, and Resistance to Inhibition of Digital and Nondigital Polymerase Chain Reaction and Loop Mediated Isothermal Amplification Assays for Quantification of Human Cytomegalovirus by Nixon, Gavin, Garson, Jeremy A, Grant, Paul, Nastouli, Eleni, Foy, Carole A., Huggett, Jim F.

“…Performing nucleic acid amplification techniques (NAATs) in digital format using limiting dilution provides potential advantages that have recently been…”
Get full text

Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host by Schurich, Anna, Pallett, Laura J., Jajbhay, Danyal, Wijngaarden, Jessica, Otano, Itziar, Gill, Upkar S., Hansi, Navjyot, Kennedy, Patrick T., Nastouli, Eleni, Gilson, Richard, Frezza, Christian, Henson, Sian M., Maini, Mala K.

“…T cells undergo profound metabolic changes to meet the increased energy demands of maintaining an antiviral response. We postulated that differences in…”
Get full text

Persistent Zika Virus Detection in Semen in a Traveler Returning to the United Kingdom from Brazil, 2016 by Gaskell, Katherine M, Houlihan, Catherine, Nastouli, Eleni, Checkley, Anna M

“…Zika virus is normally transmitted by mosquitos, but cases of sexual transmission have been reported. We describe a patient with symptomatic Zika virus…”
Get full text

Biological sex is associated with heterogeneous responses to IL-6 receptor inhibitor treatment in COVID-19—A retrospective cohort study by Stein, Dan F., Foley, Conor, Byott, Matt, Nastouli, Eleni, Ambler, Gareth, Arulkumaran, Nishkantha

“…COVID-19 is associated with higher inflammatory markers, illness severity and mortality in males compared to females. Differences in immune responses to…”
Get full text

Factors influencing uptake of protective behaviours by healthcare workers in England during the COVID-19 pandemic: A theory-based mixed-methods study by Meyer, Carly, Crayton, Elise, Wright, Abigail, Spyer, Moira, Vora, Nina, Houlihan, Catherine, Walker, Naomi F, Nastouli, Eleni, Michie, Susan, Lorencatto, Fabiana

“…Hospital infection control policies protect patients and healthcare workers (HCWs) and limit the spread of pathogens, but adherence to COVID-19 guidance…”
Get full text

The third signal cytokine IL-12 rescues the anti-viral function of exhausted HBV-specific CD8 T cells by Schurich, Anna, Pallett, Laura J, Lubowiecki, Marcin, Singh, Harsimran D, Gill, Upkar S, Kennedy, Patrick T, Nastouli, Eleni, Tanwar, Sudeep, Rosenberg, William, Maini, Mala K

“…Optimal immune activation of naïve CD8 T cells requires signal 1 mediated by the T cell receptor, signal 2 mediated by co-stimulation and signal 3 provided by…”
Get full text

Full-genome deep sequencing and phylogenetic analysis of novel human betacoronavirus by Cotten, Matthew, Lam, Tommy T, Watson, Simon J, Palser, Anne L, Petrova, Velislava, Grant, Paul, Pybus, Oliver G, Rambaut, Andrew, Guan, Yi, Pillay, Deenan, Kellam, Paul, Nastouli, Eleni

“…A novel betacoronavirus associated with lethal respiratory and renal complications was recently identified in patients from several countries in the Middle…”
Get full text

T cell immune discriminants of HIV reservoir size in a pediatric cohort of perinatally infected individuals by Rinaldi, Stefano, de Armas, Lesley, Dominguez-Rodríguez, Sara, Pallikkuth, Suresh, Dinh, Vinh, Pan, Li, Gӓrtner, Kathleen, Pahwa, Rajendra, Cotugno, Nicola, Rojo, Pablo, Nastouli, Eleni, Klein, Nigel, Foster, Caroline, De Rossi, Anita, Giaquinto, Carlo, Rossi, Paolo, Palma, Paolo, Pahwa, Savita

“…The size of the latent HIV reservoir is associated with the timing of therapeutic interventions and overall health of the immune system. Here, we demonstrate…”
Get full text

Nucleocapsid and spike antibody responses following virologically confirmed SARS-CoV-2 infection: an observational analysis in the Virus Watch community cohort by Navaratnam, Annalan M D, Shrotri, Madhumita, Nguyen, Vincent, Braithwaite, Isobel, Beale, Sarah, Byrne, Thomas E, Fong, Wing Lam Erica, Fragaszy, Ellen, Geismar, Cyril, Hoskins, Susan, Kovar, Jana, Patel, Parth, Yavlinsky, Alexei, Aryee, Anna, Rodger, Alison, Hayward, Andrew C, Aldridge, Robert W, Michie, Susan, Hardelid, Pia, Wijlaars, Linda, Nastouli, Eleni, Spyer, Moira, Killingley, Ben, Cox, Ingemar, Lampos, Vasileios, McKendry, Rachel A, Cheng, Tao, Liu, Yunzhe, Gibbs, Jo, Gilson, Richard, Johnson, Anne M

“…•If infection was confirmed by PCR, 80% of individuals were positive for nucleocapsid antibody.•The median nucleocapsid antibody level peaked between days 90…”
Get full text

Comparison of new and emerging SARS-CoV-2 variant transmissibility through active contact testing. A comparative cross-sectional household seroprevalence study by Gaskell, Katherine M, El Kheir, Natalie, Mirfendesky, Mariyam, Rampling, Tommy, Marks, Michael, Houlihan, Catherine F, Lemonge, Norbert, Bristowe, Hannah, Aslam, Suhail, Kyprianou, Demetra, Nastouli, Eleni, Goldblatt, David, Fielding, Katherine, Moore, David A J

“…Historically SARS-CoV-2 secondary attack rates (SAR) have been based on PCR positivity on screening symptomatic contacts; this misses transmission events and…”
Get full text

Virological failure, HIV-1 drug resistance, and early mortality in adults admitted to hospital in Malawi: an observational cohort study by Gupta-Wright, Ankur, Fielding, Katherine, van Oosterhout, Joep J, Alufandika, Melanie, Grint, Daniel J, Chimbayo, Elizabeth, Heaney, Judith, Byott, Matthew, Nastouli, Eleni, Mwandumba, Henry C, Corbett, Elizabeth L, Gupta, Ravindra K

“…Antiretroviral therapy (ART) scale-up in sub-Saharan Africa combined with weak routine virological monitoring has driven increasing HIV drug resistance. We…”
Get full text

In Depth Viral Diversity Analysis in Atypical Neurological and Neonatal Chikungunya Infections in Rio de Janeiro, Brazil by Torres, Maria Celeste, Di Maio, Fatima, Brown, David, Spyer, Moira, Nastouli, Eleni, Brasil, Patrícia, Bispo de Filippis, Ana Maria

“…Chikungunya virus (CHIKV) is an arthropod-borne virus (arbovirus) transmitted by Aedes mosquitoes. The human infection usually manifests as a febrile and…”
Get full text

Detection of Rare Drug Resistance Mutations by Digital PCR in a Human Influenza A Virus Model System and Clinical Samples by Whale, Alexandra S, Bushell, Claire A, Grant, Paul R, Cowen, Simon, Gutierrez-Aguirre, Ion, O'Sullivan, Denise M, Žel, Jana, Milavec, Mojca, Foy, Carole A, Nastouli, Eleni, Garson, Jeremy A, Huggett, Jim F

“…Digital PCR (dPCR) is being increasingly used for the quantification of sequence variations, including single nucleotide polymorphisms (SNPs), due to its high…”
Get full text