Search Results - "Nasti, Tahseen H"

Inflammasome Activation of IL-1 Family Mediators in Response to Cutaneous Photodamage by Nasti, Tahseen H., Timares, Laura

“…Although keratinocytes are relatively resistant to ultraviolet radiation (UVR) induced damage, repeated UVR exposure result in accumulated DNA mutations that…”
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Radiation, Immune Checkpoint Blockade and the Abscopal Effect: A Critical Review on Timing, Dose and Fractionation by Buchwald, Zachary S, Wynne, Jacob, Nasti, Tahseen H, Zhu, Simeng, Mourad, Waleed F, Yan, Weisi, Gupta, Seema, Khleif, Samir N, Khan, Mohammad K

“…The combination of radiation and immunotherapy is currently an exciting avenue of pre-clinical and clinical investigation. The synergy between these two…”
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Tumor-draining lymph node is important for a robust abscopal effect stimulated by radiotherapy by Buchwald, Zachary S, Nasti, Tahseen H, Lee, Judong, Eberhardt, Christiane S, Wieland, Andreas, Im, Se Jin, Lawson, David, Curran, Walter, Ahmed, Rafi, Khan, Mohammad K

“…BackgroundRadiotherapy (RT) has been shown to stimulate an antitumor immune response in irradiated tumors as well as unirradiated distant sites (abscopal…”
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Exosomes, Their Biogenesis and Role in Inter-Cellular Communication, Tumor Microenvironment and Cancer Immunotherapy by Jella, Kishore Kumar, Nasti, Tahseen H, Li, Zhentian, Malla, Sudarshan R, Buchwald, Zachary S, Khan, Mohammad K

“…Exosomes are extracellular vesicles ranging from 30 to 150 nm in diameter that contain molecular constituents of their host cells. They are released from…”
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Impact of Sequencing Radiation Therapy and Immune Checkpoint Inhibitors in the Treatment of Melanoma Brain Metastases by Pomeranz Krummel, Daniel A., Nasti, Tahseen H., Izar, Benjamin, Press, Robert H., Xu, Maxwell, Lowder, Lindsey, Kallay, Laura, Rupji, Manali, Rosen, Havi, Su, Jing, Curran, Walter, Olson, Jeffrey, Weinberg, Brent, Schniederjan, Matthew, Neill, Stewart, Lawson, David, Kowalski, Jeanne, Khan, Mohammad K., Sengupta, Soma

“…Melanoma brain metastases (MBM) occur in ∼50% of melanoma patients. Although both radiation therapy (RT) and immune checkpoint inhibitor (ICI) are used alone…”
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Vaccination against Cancer or Infectious Agents during Checkpoint Inhibitor Therapy by Nasti, Tahseen H, Eberhardt, Christiane S

“…The use of immune checkpoint inhibitors (ICI) has substantially increased the overall survival of cancer patients and has revolutionized the therapeutic…”
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Immunoprevention of chemical carcinogenesis through early recognition of oncogene mutations by Nasti, Tahseen H, Rudemiller, Kyle J, Cochran, J Barry, Kim, Hee Kyung, Tsuruta, Yuko, Fineberg, Naomi S, Athar, Mohammad, Elmets, Craig A, Timares, Laura

“…Prevention of tumors induced by environmental carcinogens has not been achieved. Skin tumors produced by polyaromatic hydrocarbons, such as…”
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MC1R, Eumelanin and Pheomelanin: Their Role in Determining the Susceptibility to Skin Cancer by Nasti, Tahseen H., Timares, Laura

“…Skin pigmentation is due to the accumulation of two types of melanin granules in the keratinocytes. Besides being the most potent blocker of ultraviolet…”
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Cell mediated immune responses through TLR4 prevents DMBA-induced mammary carcinogenesis in mice by Naseemuddin, Mohammed, Iqbal, Aneeqa, Nasti, Tahseen H., Ghandhi, Jennifer L., Kapadia, Akash D., Yusuf, Nabiha

“…Toll‐like receptors (TLRs) activate signals that are critically involved in the initiation of adaptive immune responses and many tumorigenic chemicals have…”
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Heat Shock Proteins HSP27 and HSP70 Are Present in the Skin and Are Important Mediators of Allergic Contact Hypersensitivity by Yusuf, Nabiha, Nasti, Tahseen H, Huang, Chun-Ming, Huber, Brad S, Jaleel, Tarannum, Lin, Hui-Yi, Xu, Hui, Elmets, Craig A

“…Proteomic analysis of murine skin has shown that a variety of heat shock proteins (HSPs) are constitutively expressed in the skin. Using murine allergic…”
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Protective Role of Toll-like Receptor 4 during the Initiation Stage of Cutaneous Chemical Carcinogenesis by YUSUF, Nabiha, NASTI, Tahseen H, LONG, J. Alan, NASEEMUDDIN, Mohammed, LUCAS, Alan P, HUI XU, ELMETS, Craig A

“…Toll-like receptors (TLR) activate multiple steps in inflammatory reactions in innate immune responses. They also activate signals that are critically involved…”
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BA.5 bivalent booster vaccination enhances neutralization of XBB.1.5, XBB.1.16 and XBB.1.9 variants in patients with lung cancer by Valanparambil, Rajesh M., Lai, Lilin, Johns, Margaret A., Davis-Gardner, Meredith, Linderman, Susanne L., McPherson, Tarrant Oliver, Chang, Andres, Akhtar, Akil, Gamarra, Estefany L. Bocangel, Matia, Hayley, McCook-Veal, Ashley A., Switchenko, Jeffrey, Nasti, Tahseen H., Green, Felicia, Saini, Manpreet, Wieland, Andreas, Pinsky, Benjamin A., Solis, Daniel, Dhodapkar, Madhav V., Carlisle, Jennifer, Ramalingam, Suresh, Ahmed, Rafi, Suthar, Mehul S.

“…This study reports that most patients with NSCLC had a significant increase in the nAb response to the currently circulating Omicron variants after bivalent…”
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Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy by Im, Se Jin, Hashimoto, Masao, Gerner, Michael Y., Lee, Junghwa, Kissick, Haydn T., Burger, Matheus C., Shan, Qiang, Hale, J. Scott, Lee, Judong, Nasti, Tahseen H., Sharpe, Arlene H., Freeman, Gordon J., Germain, Ronald N., Nakaya, Helder I., Xue, Hai-Hui, Ahmed, Rafi

“…Chronic infection with lymphocytic choriomeningitis virus promotes the establishment of a population of stem-like PD-1 + CD8 + T cells that reside in lymphoid…”
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Functional HPV-specific PD-1+ stem-like CD8 T cells in head and neck cancer by Eberhardt, Christiane S., Kissick, Haydn T., Patel, Mihir R., Cardenas, Maria A., Prokhnevska, Nataliya, Obeng, Rebecca C., Nasti, Tahseen H., Griffith, Christopher C., Im, Se Jin, Wang, Xu, Shin, Dong M., Carrington, Mary, Chen, Zhuo G., Sidney, John, Sette, Alessandro, Saba, Nabil F., Wieland, Andreas, Ahmed, Rafi

“…T cells are important in tumour immunity but a better understanding is needed of the differentiation of antigen-specific T cells in human cancer 1 , 2 . Here…”
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Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1–targeted therapy in lung cancer patients by Kamphorst, Alice O., Pillai, Rathi N., Yang, Shu, Nasti, Tahseen H., Akondy, Rama S., Wieland, Andreas, Sica, Gabriel L., Yu, Ke, Koenig, Lydia, Patel, Nikita T., Behera, Madhusmita, Wu, Hong, McCausland, Megan, Chen, Zhengjia, Zhang, Chao, Khuri, Fadlo R., Owonikoko, Taofeek K., Ahmed, Rafi, Ramalingam, Suresh S.

“…Exhausted T cells in chronic infections and cancer have sustained expression of the inhibitory receptor programmed cell death 1 (PD-1). Therapies that block…”
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4-1BB (CD137) and radiation therapy: A case report and literature review by Shiao, Jay C., BS MSc, Bowers, Nathan, BS PhD, Nasti, Tahseen H., PhD, Khosa, Faisal, MD, Khan, Mohammad K., MD PhD

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Low‐dose whole‐lung radiation for COVID‐19 pneumonia: Planned day 7 interim analysis of a registered clinical trial by Hess, Clayton B., Buchwald, Zachary S., Stokes, William, Nasti, Tahseen H., Switchenko, Jeffrey M., Weinberg, Brent D., Steinberg, James P., Godette, Karen D., Murphy, David, Ahmed, Rafi, Curran, Walter J., Khan, Mohammad K.

“…Background Individuals of advanced age with comorbidities face a higher risk of death from coronavirus disease 2019 (COVID‐19), especially once they are…”
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The antiproliferative function of violacein-like purple violet pigment (PVP) from an Antarctic Janthinobacterium sp. Ant5-2 in UV-induced 2237 fibrosarcoma by Mojib, Nazia, Nasti, Tahseen H., Andersen, Dale T., Attigada, Venkatram R., Hoover, Richard B., Yusuf, Nabiha, Bej, Asim K.

“…Background  In this study, we have investigated the chemotherapeutic potential of a purple violet pigment (PVP), which was isolated from a previously…”
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Exosome-Containing Preparations From Postirradiated Mouse Melanoma Cells Delay Melanoma Growth In Vivo by a Natural Killer Cell–Dependent Mechanism by Jella, Kishore Kumar, Nasti, Tahseen H., Li, Zhentian, Lawson, David H., Switchenko, Jeffrey M., Ahmed, Rafi, Dynan, William S., Khan, Mohammad K.

“…To investigate the ability of radiation to stimulate exosome release from melanoma cells and to characterize the resulting exosome-containing vesicle…”
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Characteristics and anatomic location of PD-1 + TCF1 + stem-like CD8 T cells in chronic viral infection and cancer by Im, Se Jin, Obeng, Rebecca C, Nasti, Tahseen H, McManus, Daniel, Kamphorst, Alice O, Gunisetty, Sivaram, Prokhnevska, Nataliya, Carlisle, Jennifer W, Yu, Ke, Sica, Gabriel L, Cardozo, Lucas E, Gonçalves, André N A, Kissick, Haydn T, Nakaya, Helder I, Ramalingam, Suresh S, Ahmed, Rafi

“…CD8 T cells play an essential role in antitumor immunity and chronic viral infections. Recent findings have delineated the differentiation pathway of CD8 T…”
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