Effect of endoscopic sinus surgery on clinical outcomes in DeltaF508 cystic fibrosis patients

Effect of endoscopic sinus surgery on clinical outcomes in DeltaF508 cystic fibrosis patients

Objectives Chronic rhinosinusitis (CRS) is prevalent in the Cystic Fibrosis (CF) population. CRS exacerbations in CF are thought to contribute to pulmonary exacerbations. Literature regarding the impact of endoscopic sinus surgery (ESS) is inconclusive. This study examines rates of lung function dec...

Full description

Saved in:
Bibliographic Details
Published in:Clinical otolaryngology Vol. 46; no. 5; pp. 941 - 947
Main Authors: Dadgostar, Anali, Nassiri, Sepehr, Quon, Bradley S., Manji, Jamil, Alsalihi, Salahuddin, Javer, Amin
Format: Journal Article
Language:English
Published: England Wiley Subscription Services, Inc 01-09-2021
Subjects:
Adult
Antibiotics
Chronic Disease
Cystic fibrosis
Cystic Fibrosis - complications
Cystic Fibrosis - physiopathology
Endoscopy
Endoscopy - methods
Female
forced expiratory volume
Genotypes
Humans
lung function
Lungs
Male
Medical records
nasal polyposis
outcomes
Patients
Respiratory function
Respiratory Function Tests
Retrospective Studies
Rhinitis - etiology
Rhinitis - surgery
Rhinosinusitis
sinus surgery
sinusitis
Sinusitis - etiology
Sinusitis - surgery
Surgery
Symptom Flare Up
lung function
outcomes
cystic fibrosis
sinus surgery
forced expiratory volume
sinusitis
nasal polyposis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives Chronic rhinosinusitis (CRS) is prevalent in the Cystic Fibrosis (CF) population. CRS exacerbations in CF are thought to contribute to pulmonary exacerbations. Literature regarding the impact of endoscopic sinus surgery (ESS) is inconclusive. This study examines rates of lung function decline and pulmonary exacerbation in CF patients who have undergone ESS. Design Retrospective review of medical records. Setting Academic Hospital. Participants 40 adult CF patients. Main outcome measures Rate of lung function decline (% predicted Forced Expiratory Volume in 1 second [ppFEV1]), number of pulmonary exacerbations (IV/oral antibiotic therapy ± hospital admission) and total number days hospitalised 2‐year postoperatively was collected. CRS patients undergoing ESS were matched to those without ESS by gender, age, and F508del genotype. Results Forty patients (mean age 37.4, 60% male) were reviewed. No significant difference was found between the surgical group and controls in baseline ppFEV1(72.5% vs. 72.7%, P = .98), 2‐year preoperative number of pulmonary exacerbations (3.05 vs. 1.65, P = .10), or Lund‐Mackay scores (12.25 vs. 11.55, P = .71). No significant difference was found in 1‐year (70.5% vs. 72.8%, P = .84) or 2‐year (70.4% vs. 72.6% P = .80) postoperative ppFEV1 and 2‐year postoperative pulmonary exacerbations (1.7 vs. 1.45, P = .87). A significant increase was identified in total number days hospitalised postoperatively (4.85, P = .02). In the surgical group, no significant difference was identified between preoperative and postoperative ppFEV1, 1 year (−2.51%, P = .32) and 2 years after ESS (−3.10%, P = .51), postoperative rate of pulmonary exacerbations (−1.28, P = .11), or in total number days hospitalised (3.74, P = .14). Conclusions In this study, ESS does not appear to significantly improve ppFEV1 or decrease the number of pulmonary exacerbations postoperatively.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1749-4478
1749-4486
DOI:10.1111/coa.13751