Search Results - "Nassir, Fatiha"

NAFLD: Mechanisms, Treatments, and Biomarkers by Nassir, Fatiha

“…Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-associated fatty liver disease (MAFLD), is one of the most common causes of liver diseases…”
Get full text

Sirtuins and nonalcoholic fatty liver disease by Nassir, Fatiha, Ibdah, Jamal A

“…Mammalian sirtuins are seven members belonging to the silent information regulator 2 family, a group of Class Ⅲ histone/protein deacetylases. Sirtuins(SIRT…”
Get full text

Role of mitochondria in nonalcoholic fatty liver disease by Nassir, Fatiha, Ibdah, Jamal A

“…Nonalcoholic fatty liver disease (NAFLD) affects about 30% of the general population in the United States and includes a spectrum of disease that includes…”
Get full text

Role of acetylation in nonalcoholic fatty liver disease: a focus on SIRT1 and SIRT3 by Nassir, Fatiha

“…Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent liver chronic disease worldwide. The pathogenesis of NAFLD is complex and involves many…”
Get full text

Role of mitochondria in alcoholic liver disease by Nassir, Fatiha, Ibdah, Jamal A

“…Alcohol abuse is the leading cause of liver related morbidity and mortality.Chronic or binge alcohol drinking causes hepatic steatosis which can develop to…”
Get full text

Regulation of mitochondrial trifunctional protein modulates nonalcoholic fatty liver disease in mice by Nassir, Fatiha, Arndt, Justin J., Johnson, Sarah A., Ibdah, Jamal A.

“…Mitochondrial trifunctional protein (MTP) plays a critical role in the oxidation of long-chain fatty acids. We previously reported that aging mice (>9 months…”
Get full text

CD36 deletion reduces VLDL secretion, modulates liver prostaglandins, and exacerbates hepatic steatosis in ob/ob mice[S] by Nassir, Fatiha, Adewole, Okunade L., Brunt, Elizabeth M., Abumrad, Nada A.

“…Recent findings described the role of CD36-mediated signaling in regulating cellular calcium and the release of various bioactive molecules, including the…”
Get full text

CD36 Is Important for Fatty Acid and Cholesterol Uptake by the Proximal but Not Distal Intestine by Nassir, Fatiha, Wilson, Brody, Han, Xianlin, Gross, Richard W., Abumrad, Nada A.

“…CD36, a membrane protein that facilitates fatty acid uptake, is highly expressed in the intestine on the luminal surface of enterocytes. Cd36 null (Cd36–/–)…”
Get full text

Non-Alcoholic Fatty Pancreas Disease (NAFPD): A Silent Spectator or the Fifth Component of Metabolic Syndrome? A Literature Review by Romana, Bhupinder S, Chela, Harleen, Dailey, Francis E, Nassir, Fatiha, Tahan, Veysel

“…Fat accumulation in the pancreas has remained a relatively unknown disease since it was initially described in 1926. However, it has gained increasing…”
Get more information

CD36 Is Important for Chylomicron Formation and Secretion and May Mediate Cholesterol Uptake in the Proximal Intestine by Nauli, Andromeda M., Nassir, Fatiha, Zheng, Shuqin, Yang, Qing, Lo, Chun–Min, VonLehmden, Sarah B., Lee, Dana, Jandacek, Ronald J., Abumrad, Nada A., Tso, Patrick

“…Background & Aims: Studies are aimed to determine the role of CD36 in intestinal lipid absorption. Methods: Knock-out (KO) and wild-type (WT) lymph fistula…”
Get full text

Enhanced hepatic apoA-I secretion and peripheral efflux of cholesterol and phospholipid in CD36 null mice by Yue, Pin, Chen, Zhouji, Nassir, Fatiha, Bernal-Mizrachi, Carlos, Finck, Brian, Azhar, Salman, Abumrad, Nada A

“…CD36 facilitates oxidized low density lipoprotein uptake and is implicated in development of atherosclerotic lesions. CD36 also binds unmodified high and very…”
Get full text

Hepatic secretion of small lipoprotein particles in apobec-1-/- mice is regulated by the LDL receptor by Nassir, Fatiha, Xie, Yan, Patterson, Bruce W, Luo, Jianyang, Davidson, Nicholas O

“…Recent studies have examined the role of the LDL receptor (LDLR) in regulating murine hepatic lipoprotein production and apolipoprotein B (apoB) secretion,…”
Get full text

Homeodomain Factor Nkx2-3 Controls Regional Expression of Leukocyte Homing Coreceptor MAdCAM-1 in Specialized Endothelial Cells of the Viscera by Wang, Cheng-Chun, Biben, Christine, Robb, Lorraine, Nassir, Fatiha, Barnett, Louise, Davidson, Nicholas O., Koentgen, Frank, Tarlinton, David, Harvey, Richard P.

“…Regulated emigration of blood-borne leukocytes plays a defining role in lymphoid organ development, immune surveillance, and inflammatory responses. We report…”
Get full text

Pathogenesis and Prevention of Hepatic Steatosis by Nassir, Fatiha, Rector, R Scott, Hammoud, Ghassan M, Ibdah, Jamal A

“…Hepatic steatosis is defined as intrahepatic fat of at least 5% of liver weight. Simple accumulation of triacylglycerols in the liver could be…”
Get full text

Thyroid Hormone Regulates Hepatic Triglyceride Mobilization and Apolipoprotein B Messenger Ribonucleic Acid Editing in a Murine Model of Congenital Hypothyroidism by Mukhopadhyay, Debnath, Plateroti, Michelina, Anant, Shrikant, Nassir, Fatiha, Samarut, Jacques, Davidson, Nicholas O

“…Thyroid hormone modulates the expression of numerous genes that in turn regulate lipoprotein metabolism in vivo. We have examined the thyroid hormone-dependent…”
Get full text

Apolipoprotein(a) Synthesis and Secretion from Hepatoma Cells Is Coupled to Triglyceride Synthesis and Secretion by Nassir, F, Bonen, D K, Davidson, N O

“…Apolipoprotein(a) (apo(a)) is synthesized and secreted from liver cells and represents one of the two major protein components of the atherogenic lipoprotein,…”
Get full text

Apolipoprotein[a] secretion from hepatoma cells is regulated in a size-dependent manner by alterations in disulfide bond formation by Nassir, Fatiha, Xie, Yan, Davidson, Nicholas O

“…Apolipoprotein[a] (apo[a]) is a large disulfide linked glycoprotein synthesized by hepatocytes. We have examined the role of disulfide bond formation in the…”
Get full text

CD36‐dependent signaling mediates fatty acid‐induced gut release of secretin and cholecystokinin by Sundaresan, Sinju, Shahid, Rafiq, Riehl, Terrence E., Chandra, Rashmi, Nassir, Fatiha, Stenson, William F., Liddle, Rodger A., Abumrad, Nada A.

“…Genetic variants in the fatty acid (FA) translocase FAT/CD36 associate with abnormal postprandial lipids and influence risk for the metabolic syndrome. CD36 is…”
Get full text

Luminal Lipid Regulates CD36 Levels and Downstream Signaling to Stimulate Chylomicron Synthesis by Tran, Thi Thu Trang, Poirier, Hélène, Clément, Lionel, Nassir, Fatiha, Pelsers, Maurice M.A.L., Petit, Valérie, Degrace, Pascal, Monnot, Marie-Claude, Glatz, Jan F.C., Abumrad, Nada A., Besnard, Philippe, Niot, Isabelle

“…The membrane glycoprotein CD36 binds nanomolar concentrations of long chain fatty acids (LCFA) and is highly expressed on the luminal surface of enterocytes…”
Get full text

Inhibition of N-linked glycosylation results in retention of intracellular apo[a] in hepatoma cells, although nonglycosylated and immature forms of apolipoprotein[a] are competent to associate with apolipoprotein B-100 in vitro by Bonen, D K, Nassir, F, Hausman, A M, Davidson, N O

“…Apolipoprotein[a] (apo[a]) is a highly polymorphic glycoprotein that forms a covalent complex with apolipoprotein B-100 (apoB-100), producing a lipoprotein…”
Get full text