Search Results - "Nasseri, Seyed A"
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Bioelectrocatalysis with a palladium membrane reactor
Published in Nature communications (31-03-2023)“…Enzyme catalysis is used to generate approximately 50,000 tons of value-added chemical products per year. Nearly a quarter of this production requires a…”
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2
Bacterial catabolism of acetovanillone, a lignin-derived compound
Published in Proceedings of the National Academy of Sciences - PNAS (25-10-2022)“…Bacterial catabolic pathways have considerable potential as industrial biocatalysts for the valorization of lignin, a major component of plant-derived biomass…”
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3
N -Alkylated Iminosugar Based Ligands: Synthesis and Inhibition of Human Lysosomal β-Glucocerebrosidase
Published in Molecules (Basel, Switzerland) (11-10-2020)“…The scope of a series of -alkylated iminosugar based inhibitors in the d- as well as d- configuration towards their interaction with human lysosomal…”
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Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C -5a-Substituted Derivatives of 4- epi -Isofagomine
Published in Molecules (Basel, Switzerland) (03-09-2020)“…Glycosidase inhibitors have shown great potential as pharmacological chaperones for lysosomal storage diseases. In light of this, a series of new…”
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Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols
Published in Molecules (Basel, Switzerland) (20-03-2018)“…From 1,2;3,4-di- -isopropylidene-d-galactopyranose, a preliminary series of highly functionalized amino(hydroxymethyl)cyclopentanes was easily available. These…”
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6
Characterization of a new family of 6-sulfo-N-acetylglucosaminidases
Published in The Journal of biological chemistry (01-10-2023)“…Sulfation is widespread in nature and plays an important role in modulating biological function. Among the strategies developed by microbes to access sulfated…”
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Synthesis and glycosidase inhibition of 3,4,5-trihydroxypiperidines using a one-pot amination-cyclisation cascade reaction
Published in Carbohydrate research (01-09-2024)“…Trihydroxypiperidines are a therapeutically valuable class of iminosugar. We applied a one-pot amination-cyclisation cascade reaction to synthesise…”
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8
Ligand-Directed Chemistry on Glycoside Hydrolases - A Proof of Concept Study
Published in Chembiochem : a European journal of chemical biology (01-12-2023)“…Selective covalent labelling of enzymes using small molecule probes has advanced the scopes of protein profiling. The covalent bond formation to a specific…”
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9
N‐Methyl‐N‐Alkylaminocyclopentanes: Powerful and Selective β‐d‐Glucocerebrosidase Inhibitors
Published in Helvetica chimica acta (01-04-2024)“…Building upon a previously established (2+3)‐cycloaddition strategy, a series of N,N‐dialkylated aminocyclopentanes was synthesized using a partially protected…”
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New α-galactosidase-inhibiting aminohydroxycyclopentanes
Published in RSC advances (29-04-2021)“…A set of cyclopentanoid α-galactosidase ligands was prepared from a partially protected ω-eno-aldose via a reliable (2 + 3)-cycloaddition protocol with…”
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Synthesis of modified 1,5-imino-d-xylitols as ligands for lysosomal β-glucocerebrosidase
Published in Monatshefte für Chemie (01-01-2019)“…Modified 1,5-dideoxy-1,5-imino- d -xylitol analogues with different substitution patterns involving position C-1 and/or the ring nitrogen were prepared, which…”
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Biologically active branched-chain aminocyclopentane tetraols from d-galactose
Published in Monatshefte für Chemie (01-05-2019)“…From 1,2;3,4-di- O -isopropylidene- d -galactopyranose, a series of highly functionalized branched-chain cyclopentanes was easily available. The initial…”
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13
Ultrahigh-Throughput Single Emulsion Droplet Screening for the Discovery of New B Antigen Cleaving Enzymes
Published in ACS catalysis (06-09-2024)“…In search of efficient α-galactosidases that can convert B red blood cells (RBCs) to universal type RBCs, we have developed a simple and robust system for…”
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Cobalt as a Cofactor for α‑Galactosaminidase-Catalyzed Cleavage of Blood Group Antigens
Published in ACS catalysis (06-09-2024)“…Enzymatic cleavage of the terminal α-N-acetylgalactosamine of the A-antigen of red blood cells by gut commensal organisms such as Flavonifractor plautii is…”
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