Search Results - "Nasser S.M. Ismail"

Molecular modeling based approach, synthesis and in vitro assay to new indole inhibitors of hepatitis C NS3/4A serine protease by Ismail, Nasser S.M., Hattori, Masao

“…In an attempt to identify potential HCV NS3 protease inhibitors lead compounds, a series of novel indoles (10a–g) was designed. Molecular modeling study,…”
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Design, synthesis and biological study of novel pyrido[2,3-d]pyrimidine as anti-proliferative CDK2 inhibitors by Ibrahim, Diaa A., Ismail, Nasser S.M.

“…The design and synthesis of a small library of 4-aminopyrido[2,3-d]pyrimidine derivatives is reported. The potential activity of these compounds as CDK2/Cyclin…”
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Design and Synthesis of New CDK2 Inhibitors Containing Thiazolone and Thiazolthione Scafold with Apoptotic Activity by Nour E. A. Abd El-Sattar, Badawy, Eman H. K., AbdEl-Hady, Wafaa H., Abo-Alkasem, Mohamed I., Mandour, Asmaa A., Ismail, Nasser S. M.

“…Cyclin dependent kinase 2 (CDK2) inhibition is a well-established strategy for treating cancer. Different series of novel thiazolone (1, 7–9) together with…”
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Therapeutic Potential of Vanillin and its Main Metabolites to Regulate the Inflammatory Response and Oxidative Stress by Bezerra-Filho, Carlos S M, Barboza, Joice N, Souza, Marilia T S, Sabry, Peter, Ismail, Nasser S M, de Sousa, Damião P

“…Many phenolic compounds found in foods and medicinal plants have shown interesting therapeutic potential and have attracted the attention of the pharmaceutical…”
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Synthesis and biological activity of new 18β-glycyrrhetinic acid derivatives by Radwan, Mohamed O., Ismail, Mohamed A.H., El-Mekkawy, Sahar, Ismail, Nasser S.M., Hanna, Atef G.

“…In an attempt to find out new, potent and safe anti-inflammatory molecules and as a contribution in the chemistry of triterpenes, a series of…”
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Regioselective synthesis and molecular modeling study of vasorelaxant active 7,9-dioxa-1,2-diaza-spiro[4.5]dec-2-ene-6,10-diones by Girgis, Adel S., Ismail, Nasser S.M., Farag, Hanaa, El-Eraky, Wafaa I., Saleh, Dalia O., Tala, Srinivasa R., Katritzky, Alan R.

“…Nitrilimines (PhC −:N +:NR′) generated in situ from hydrazonoyl chlorides 2a,b reacted regioselectively with 5-arylidene-2,2-dimethyl[1,3]dioxane-4,6-diones…”
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Analogs design, synthesis and biological evaluation of peptidomimetics with potential anti-HCV activity by Lasheen, Deena S., Ismail, Mohamed A.H., Abou El Ella, Dalal A., Ismail, Nasser S.M., Eid, Sameh, Vleck, Susan, Glenn, Jeffrey S., Watts, Andrew G., Abouzid, Khaled A.M.

“…Peptidomimetics bearing a C-terminal carboxylate or vinyl sulfonate functionality as HCV NS3 protease inhibitors. Two series of peptidomimetics were designed,…”
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Recent advances in 4-aminoquinazoline based scaffold derivatives targeting EGFR kinases as anticancer agents by Rania S.M. Ismail, Nasser S.M. Ismail, Sahar Abuserii, Dalal A. Abou El Ella

“…Quinazoline derivatives are fused heterocyclic ring systems which have been explored for their inhibitory activity towards various protein kinase enzymes and…”
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A molecular docking study repurposes FDA approved iron oxide nanoparticles to treat and control COVID-19 infection by Abo-zeid, Yasmin, Ismail, Nasser S.M., McLean, Gary R., Hamdy, Nadia M.

“…COVID-19, is a disease resulting from the SARS-CoV-2 global pandemic. Due to the current global emergency and the length of time required to develop specific…”
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Medicinal attributes of pyrazolo[1,5-a]pyrimidine based scaffold derivatives targeting kinases as anticancer agents by Nasser S.M. Ismail, Ghada M.E. Ali, Diaa A. Ibrahim, Amira M. Elmetwali

“…Pyrazolo pyrimidines are fused heterocyclic ring systems which known as bioisosteres of adenine, that are necessary for every aspect of cell life…”
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Pyrazolo[3,4-d]pyrimidine based scaffold derivatives targeting kinases as anticancer agents by Nasser S.M. Ismail, Eslam M.H. Ali, Diaa A. Ibrahim, Rabah A.T. Serya, Dalal A. Abou El Ella

“…Pyrazolopyrimidines are fused heterocyclic ring systems which structurally can consider as bioisosteres of adenine, which is fundamental for every aspect of…”
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Alkaloids: Therapeutic Potential against Human Coronaviruses by Fielding, Burtram C, da Silva Maia Bezerra Filho, Carlos, Ismail, Nasser S M, Sousa, Damião Pergentino de

“…Alkaloids are a class of natural products known to have wide pharmacological activity and have great potential for the development of new drugs to treat a wide…”
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Discovery of pyrazolo[3,4-]pyrimidine and pyrazolo[4,3-][1,2,4]triazolo[1,5-]pyrimidine derivatives as novel CDK2 inhibitors: synthesis, biological and molecular modeling investigations by Nassar, Ibrahim F, Abdel Aal, Mohammed T, El-Sayed, Wael A, E Shahin, Mahmoud, Elsakka, Elsayed G. E, Mokhtar, Mahmoud Mohamed, Hegazy, Maghawry, Hagras, Mohamed, Mandour, Asmaa A, Ismail, Nasser S. M

“…CDK2 inhibition is an appealing target for cancer treatment that targets tumor cells in a selective manner. A new set of small molecules featuring the…”
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Synthesis and QSAR study of novel cytotoxic spiro[3 H-indole-3,2′(1′ H)-pyrrolo[3,4- c]pyrrole]-2,3′,5′(1 H,2′ aH,4′ H)-triones by Girgis, Adel S., Stawinski, Jacek, Ismail, Nasser S.M., Farag, Hanaa

“…1,3-Dipolar cycloaddition reaction of 1-aryl-1 H-pyrrole-2,5-diones 1a-e with non-stabilized azomethine ylides, generated in situ via decarboxylative…”
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Design, synthesis and QSAR studies of dispiroindole derivatives as new antiproliferative agents by George, Riham F., Ismail, Nasser S.M., Stawinski, Jacek, Girgis, Adel S.

“…A variety of 4′-aryl-3-(arylmethylidene)-1″-[(cyclic-amino)methylene]-1′-methyl-dispiro[cyclohexane-1,3′-pyrrolidine-2′,3″-[3H]indole]-2,2″(1″H)-diones 4a–u…”
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Development of pyrolo[2,3-c]pyrazole, pyrolo[2,3-d]pyrimidine and their bioisosteres as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological evaluation and molecular dynamics investigations by Azmy, Eman M., Hagras, Mohamed, Ewida, Menna A., Doghish, Ahmed S., Gamil Khidr, Emad, El-Husseiny, Ahmed A., Gomaa, Maher H., Refaat, Hanan M., Ismail, Nasser S.M., Nassar, Ibrahim F., Lashin, Walaa H.

“…[Display omitted] •A novel series of pyrolo[2,3-c]pyrazole, pyrolo[2,3-c]isoaxazole and pyrolo[2,3-d]pyrimidine, pyrolo[3,2-c]pyridine & indole scaffolds were…”
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Design, synthesis and biological evaluation of certain CDK2 inhibitors based on pyrazole and pyrazolo[1,5-a] pyrimidine scaffold with apoptotic activity by Ali, Ghada M.E., Ibrahim, Diaa A., Elmetwali, Amira M., Ismail, Nasser S.M.

“…[Display omitted] •19 Compounds were screened against CDK2/cyclin A2 enzyme.•Target compounds were assessed in vitro against MCF-7, HepG2, A549 and Caco-2…”
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Design, synthesis and molecular modeling study of certain VEGFR-2 inhibitors based on thienopyrimidne scaffold as cancer targeting agents by Ghith, Amna, Youssef, Khairia M., Ismail, Nasser S.M., Abouzid, Khaled A.M.

“…[Display omitted] •25 compounds were screened against VEGFR-2 kinase enzyme.•Selected compounds were assessed in vitro against full NCI 60 cell lines.•10a…”
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Novel series of 6-(2-substitutedacetamido)-4-anilinoquinazolines as EGFR-ERK signal transduction inhibitors in MCF-7 breast cancer cells by Ismail, Rania S.M., Abou-Seri, Sahar M., Eldehna, Wagdy M., Ismail, Nasser S.M., Elgazwi, Sara M., Ghabbour, Hazem A., Ahmed, Mahmoud Salama, Halaweish, Fathi T., Abou El Ella, Dalal A.

“…Epidermal growth factor receptor (EGFR) signaling pathway has been previously investigated for its significant role in the progression of different types of…”
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Design and Synthesis of New Quinoxaline Derivatives as Anticancer Agents and Apoptotic Inducers by El Newahie, Aliya M S, Nissan, Yassin M, Ismail, Nasser S M, Abou El Ella, Dalal A, Khojah, Sohair M, Abouzid, Khaled A M

“…The quinoxaline scaffold is a promising platform for the discovery of active chemotherapeutic agents. Three series of quinoxaline derivatives were synthesized…”
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