Search Results - "Nasser, Arafat"

Common HTR2A variants and 5‐HTTLPR are not associated with human in vivo serotonin 2A receptor levels by Spies, Marie, Nasser, Arafat, Ozenne, Brice, Jensen, Peter S., Knudsen, Gitte M., Fisher, Patrick M.

“…The serotonin 2A receptor (5‐HT2AR) is implicated in the pathophysiology and treatment of various psychiatric disorders. [18F]altanserin and [11C]Cimbi‐36…”
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Genetic contributions to brain serotonin transporter levels in healthy adults by Bruzzone, Silvia Elisabetta Portis, Nasser, Arafat, Aripaka, Sagar Sanjay, Spies, Marie, Ozenne, Brice, Jensen, Peter Steen, Knudsen, Gitte Moos, Frokjaer, Vibe Gedsoe, Fisher, Patrick MacDonald

“…The serotonin transporter (5-HTT) critically shapes serotonin neurotransmission by regulating extracellular brain serotonin levels; it remains unclear to what…”
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Stress-Hormone Dynamics and Working Memory in Healthy Women Who Use Oral Contraceptives Versus Non-Users by Høgsted, Emma Sofie, Borgsted, Camilla, Dam, Vibeke H, Nasser, Arafat, Rye Jørgensen, Niklas, Ozenne, Brice, Stenbæk, Dea Siggaard, Frokjaer, Vibe G

“…Women who use oral contraceptives (OCs) may have a higher risk of developing a depression, which is associated with both vulnerability to stress and cognitive…”
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Associations between the cortisol awakening response and patient-evaluated stress and mood instability in patients with bipolar disorder: an exploratory study by Faurholt-Jepsen, Maria, Frøkjær, Vibe Gedsø, Nasser, Arafat, Jørgensen, Niklas Rye, Kessing, Lars Vedel, Vinberg, Maj

“…Objective The Cortisol Awakening Response (CAR) measured as the transient increase in cortisol levels following morning awakening appears to be a distinct…”
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Chronic administration of the selective P2X3, P2X2/3 receptor antagonist, A-317491, transiently attenuates cancer-induced bone pain in mice by Hansen, Rikke Rie, Nasser, Arafat, Falk, Sarah, Baldvinsson, Signe B., Ohlsson, Pernille H., Bahl, Justyna M.C., Jarvis, Michael F., Ding, Ming, Heegaard, Anne-Marie

“…The purinergic P2X3 and P2X2/3 receptors are in the peripheral nervous system almost exclusively confined to afferent sensory neurons, where they are found…”
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An in vivo Pig Model for Testing Novel Positron Emission Tomography Radioligands Targeting Cerebral Protein Aggregates by Raval, Nakul Ravi, Nasser, Arafat, Madsen, Clara Aabye, Beschorner, Natalie, Beaman, Emily Eufaula, Juhl, Morten, Lehel, Szabolcs, Palner, Mikael, Svarer, Claus, Plavén-Sigray, Pontus, Jørgensen, Louise Møller, Knudsen, Gitte Moos

“…Positron emission tomography (PET) has become an essential clinical tool for diagnosing neurodegenerative diseases with abnormal accumulation of proteins like…”
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Intraplantar injection of tetrahydrobiopterin induces nociception in mice by Nasser, Arafat, Ali, Sawsan, Wilsbech, Signe, Bjerrum, Ole J., Møller, Lisbeth B.

“…•Tetrahydrobiopterin induces pro-nociceptive effects following peripheral injection.•Local pre-treatment with morphine attenuate tetrahydrobiopterin evoked…”
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Blocking of efflux transporters in rats improves translational validation of brain radioligands by Shalgunov, Vladimir, Xiong, Mengfei, L’Estrade, Elina T., Raval, Nakul R., Andersen, Ida V., Edgar, Fraser G., Speth, Nikolaj R., Baerentzen, Simone L., Hansen, Hanne D., Donovan, Lene L., Nasser, Arafat, Peitersen, Siv T., Kjaer, Andreas, Knudsen, Gitte M., Syvänen, Stina, Palner, Mikael, Herth, Matthias M.

“…Background Positron emission tomography (PET) is a molecular imaging technique that can be used to investigate the in vivo pharmacology of drugs. Initial…”
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Anxiety- and depression-like phenotype of hph-1 mice deficient in tetrahydrobiopterin by Nasser, Arafat, Møller, Lisbeth B., Olesen, Jess H., Konradsen, Louise S., Andreasen, Jesper T.

“…•The hph-1 mouse is a model of BH4 deficiency implicated in affective disorders.•Hph-1 mice display altered anxiety- and depression-like behaviours.•The…”
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Reliability of three versus five saliva sampling times for assessing the cortisol awakening response by Nasser, Arafat, Ozenne, Brice, Høgsted, Emma Sofie, Jensen, Peter Steen, Frokjaer, Vibe G.

“…The cortisol awakening response (CAR) describes the sharp increase in cortisol secretion within 60 min after awakening. A summary of the CAR, the area under…”
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Assessment of cerebral drug occupancy in humans using a single PET-scan: A 11CUCB-J PET study by Marstrand-Joergensen, Maja R, Laurell, Gjertrud L, Herrmann, Susan, Nasser, Arafat, Johansen, Annette, Lund, Anton, Andersen, Thomas L, Knudsen, Gitte M, Pinborg, Lars H

“…Here, we evaluate a PET displacement model with a Single-step and Numerical solution in healthy individuals using the synaptic vesicle glycoprotein (SV2A)…”
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Assessment of cerebral drug occupancy in humans using a single PET-scan: A [11C]UCB-J PET study by Marstrand-Joergensen, Maja R., Laurell, Gjertrud L., Herrmann, Susan, Nasser, Arafat, Johansen, Annette, Lund, Anton, Andersen, Thomas L., Knudsen, Gitte M., Pinborg, Lars H.

“…Purpose Here, we evaluate a PET displacement model with a Single-step and Numerical solution in healthy individuals using the synaptic vesicle glycoprotein…”
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Effects of escitalopram on synaptic density in the healthy human brain: a randomized controlled trial by Johansen, Annette, Armand, Sophia, Plavén-Sigray, Pontus, Nasser, Arafat, Ozenne, Brice, Petersen, Ida N., Keller, Sune H., Madsen, Jacob, Beliveau, Vincent, Møller, Kirsten, Vassilieva, Alexandra, Langley, Christelle, Svarer, Claus, Stenbæk, Dea S., Sahakian, Barbara J., Knudsen, Gitte M.

“…Selective serotonin reuptake inhibitors (SSRIs) are widely used for treating neuropsychiatric disorders. However, the exact mechanism of action and why effects…”
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Stress Hormone Dynamics Are Coupled to Brain Serotonin 4 Receptor Availability in Unmedicated Patients With Major Depressive Disorder: A NeuroPharm Study by Vulpius, Gunild M, Köhler-Forsberg, Kristin, Ozenne, Brice, Larsen, Søren V, Nasser, Arafat, Svarer, Claus, Gillings, Nic, Keller, Sune H, Jørgensen, Martin B, Knudsen, Gitte M, Frokjaer, Vibe G

“…Abstract Background A prominent finding in major depressive disorder (MDD) is distorted stress hormone dynamics, which is regulated by serotonergic brain…”
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Kinetic models for estimating occupancy from single-scan PET displacement studies by Laurell, Gjertrud Louise, Plavén-Sigray, Pontus, Johansen, Annette, Raval, Nakul Ravi, Nasser, Arafat, Aabye Madsen, Clara, Madsen, Jacob, Hansen, Hanne Demant, Donovan, Lene Lundgaard, Knudsen, Gitte Moos, Lammertsma, Adriaan A, Ogden, R Todd, Svarer, Claus, Schain, Martin

“…The traditional design of PET target engagement studies is based on a baseline scan and one or more scans after drug administration. We here evaluate an…”
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Evaluation of the α-synuclein PET radiotracer (d3)-[11C]MODAG-001 in pigs by Raval, Nakul Ravi, Madsen, Clara Aabye, Shalgunov, Vladimir, Nasser, Arafat, Battisti, Umberto Maria, Beaman, Emily Eufaula, Juhl, Morten, Jørgensen, Louise Møller, Herth, Matthias Manfred, Hansen, Hanne Demant, Plavén-Sigray, Pontus, Knudsen, Gitte Moos

“…A positron emission tomography (PET) radiotracer to neuroimage α-synuclein aggregates would be a crucial addition for early diagnosis and treatment development…”
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P2X7 receptor-deficient mice are susceptible to bone cancer pain by Hansen, Rikke Rie, Nielsen, Christian K., Nasser, Arafat, Thomsen, Stine I.M., Eghorn, Laura F., Pham, Yen, Schulenburg, Cecilia, Syberg, Susanne, Ding, Ming, Stojilkovic, Stanko S., Jorgensen, Niklas R., Heegaard, Anne-Marie

“…The purinergic P2X7 receptor is implicated in both neuropathic and inflammatory pain, and has been suggested as a possible target in pain treatment. However,…”
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Heterozygous mutations in GTP-cyclohydrolase-1 reduce BH4 biosynthesis but not pain sensitivity by Nasser, Arafat, Møller, Anette Torvin, Hellmund, Vibe, Thorborg, Sidsel Salling, Jespersgaard, Cathrine, Bjerrum, Ole J., Dupont, Erik, Nachman, Gösta, Lykkesfeldt, Jens, Jensen, Troels Staehelin, Møller, Lisbeth Birk

“…Human studies have demonstrated a correlation between noncoding polymorphisms of "the pain protective" haplotype in the GCH1 gene that encodes for GTP…”
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Corrigendum to “Anxiety- and depression-like phenotype of the hph-1 mice deficient in tetrahydrobiopterin” [Neurosci. Res. 89 (2014) 44–53] by Nasser, Arafat, Møller, Lisbeth B., Olesen, Jess H., Refsgaard, Louise K., Andreasen, Jesper T.

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GCH1 variants, tetrahydrobiopterin and their effects on pain sensitivity by Nasser, Arafat, Møller, Lisbeth Birk

“…Highlights • GCH1 gene mutations decrease pain sensitivity in experimental models of pain in humans and mice. • GCH1 gene variants in the general population…”
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