Search Results - "Nassar, Mohammed A."

Painful and painless mutations of SCN9A and SCN11A voltage-gated sodium channels by Baker, Mark D., Nassar, Mohammed A.

“…Chronic pain is a global problem affecting up to 20% of the world’s population and has a significant economic, social and personal cost to society. Sensory…”
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Pain without Nociceptors? Nav1.7-Independent Pain Mechanisms by Minett, Michael S., Falk, Sarah, Santana-Varela, Sonia, Bogdanov, Yury D., Nassar, Mohammed A., Heegaard, Anne-Marie, Wood, John N.

“…Nav1.7, a peripheral neuron voltage-gated sodium channel, is essential for pain and olfaction in mice and humans. We examined the role of Nav1.7 as well as…”
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Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain by Abrahamsen, Bjarke, Zhao, Jing, Asante, Curtis O, Cendan, Cruz Miguel, Marsh, Steve, Martinez-Barbera, Juan Pedro, Nassar, Mohammed A, Dickenson, Anthony H, Wood, John N

“…Peripheral pain pathways are activated by a range of stimuli. We used diphtheria toxin to kill all mouse postmitotic sensory neurons expressing the sodium…”
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NaV1.7 and pain: contribution of peripheral nerves by Hoffmann, Tal, Sharon, Ohad, Wittmann, Jürgen, Carr, Richard W., Vyshnevska, Alina, Col, Roberto De, Nassar, Mohammed A., Reeh, Peter W., Weidner, Christian

“…The sodium channel NaV1.7 contributes to action potential (AP) generation and propagation. Loss-of-function mutations in patients lead to congenital…”
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Parallel “Pain” Pathways Arise from Subpopulations of Primary Afferent Nociceptor by Braz, Joao M., Nassar, Mohammed A., Wood, John N., Basbaum, Allan I.

“…A major unanswered question concerning “pain” circuitry is the extent to which different populations of primary afferent nociceptor engage the same or…”
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Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia by Gaveriaux-Ruff, Claire, Nozaki, Chihiro, Nadal, Xavier, Hever, Xavier C., Weibel, Raphael, Matifas, Audrey, Reiss, David, Filliol, Dominique, Nassar, Mohammed A., Wood, John N., Maldonado, Rafael, Kieffer, Brigitte L.

“…Opioid receptors are major actors in pain control and are broadly distributed throughout the nervous system. A major challenge in pain research is the…”
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Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain by Deuis, Jennifer R, Wingerd, Joshua S, Winter, Zoltan, Durek, Thomas, Dekan, Zoltan, Sousa, Silmara R, Zimmermann, Katharina, Hoffmann, Tali, Weidner, Christian, Nassar, Mohammed A, Alewood, Paul F, Lewis, Richard J, Vetter, Irina

“…Loss-of-function mutations of Na(V)1.7 lead to congenital insensitivity to pain, a rare condition resulting in individuals who are otherwise normal except for…”
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Veratridine produces distinct calcium response profiles in mouse Dorsal Root Ganglia neurons by Mohammed, Zainab A., Doran, Ciara, Grundy, David, Nassar, Mohammed A.

“…Nociceptors are a subpopulation of dorsal root ganglia (DRG) neurons that detect noxious stimuli and signal pain. Veratridine (VTD) is a voltage-gated sodium…”
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Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds by Zhao, Jing, Lee, Man-Cheung, Momin, Ali, Cendan, Cruz-Miguel, Shepherd, Samuel T, Baker, Mark D, Asante, Curtis, Bee, Lucy, Bethry, Audrey, Perkins, James R, Nassar, Mohammed A, Abrahamsen, Bjarke, Dickenson, Anthony, Cobb, Bradly S, Merkenschlager, Matthias, Wood, John N

“…To examine the role of small RNAs in peripheral pain pathways, we deleted the enzyme Dicer in mouse postmitotic damage-sensing neurons. We used a Nav1.8-Cre…”
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GTP up-regulated persistent Na+ current and enhanced nociceptor excitability require NaV1.9 by Ostman, Johan A R, Nassar, Mohammed A, Wood, John N, Baker, Mark D

“…Persistent tetrodotoxin-resistant (TTX-r) sodium currents up-regulated by intracellular GTP have been invoked as the site of action of peripheral inflammatory…”
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Mouse DRG Cell Line with Properties of Nociceptors by Doran, Ciara, Chetrit, Jonathan, Holley, Matthew C, Grundy, David, Nassar, Mohammed A

“…In vitro cell lines from DRG neurons aid drug discovery because they can be used for early stage, high-throughput screens for drugs targeting pain pathways,…”
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GRK2: A Novel Cell-Specific Regulator of Severity and Duration of Inflammatory Pain by Eijkelkamp, Niels, Heijnen, Cobi J, Willemen, Hanneke L. D. M, Deumens, Ronald, Joosten, Elbert A. J, Kleibeuker, Wendy, den Hartog, Ilona J. M, van Velthoven, Cindy T. J, Nijboer, Cora, Nassar, Mohammed A, Dorn, Gerald W., II, Wood, John N, Kavelaars, Annemieke

“…Chronic pain associated with inflammation is a common clinical problem, and the underlying mechanisms have only begun to be unraveled. GRK2 regulates cellular…”
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Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons by Minett, Michael S., Nassar, Mohammed A., Clark, Anna K., Passmore, Gayle, Dickenson, Anthony H., Wang, Fan, Malcangio, Marzia, Wood, John N.

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RET Signaling Is Required for Survival and Normal Function of Nonpeptidergic Nociceptors by Golden, Judith P, Hoshi, Masato, Nassar, Mohammed A, Enomoto, Hideki, Wood, John N, Milbrandt, Jeffrey, Gereau, Robert W., IV, Johnson, Eugene M., Jr, Jain, Sanjay

“…Small unmyelinated sensory neurons classified as nociceptors are divided into two subpopulations based on phenotypic differences, including expression of…”
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Nociceptor-Expressed Ephrin-B2 Regulates Inflammatory and Neuropathic Pain by Zhao, Jing, Yuan, Guanglu, Cendan, Cruz M, Nassar, Mohammed A, Lagerström, Malin C, Kullander, Klas, Gavazzi, Isabella, Wood, John N

“…Background: EphB receptors and their ephrin-B ligands play an important role in nervous system development, as well as synapse formation and plasticity in the…”
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Sodium Channels and Mammalian Sensory Mechanotransduction by Raouf, Ramin, Rugiero, Francois, Kiesewetter, Hannes, Hatch, Rachel, Hummler, Edith, Nassar, Mohammed A, Wang, Fan, Wood, John N

“…Background: Members of the degenerin/epithelial (DEG/ENaC) sodium channel family are mechanosensors in C elegans, and Nav1.7 and Nav1.8 voltage-gated sodium…”
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An unbiased and efficient assessment of excitability of sensory neurons for analgesic drug discovery by Mohammed, Zainab A., Kaloyanova, Katerina, Nassar, Mohammed A.

“…Alleviating chronic pain is challenging, due to lack of drugs that effectively inhibit nociceptors without off-target effects on motor or central neurons…”
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Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons by Minett, Michael S., Nassar, Mohammed A., Clark, Anna K., Passmore, Gayle, Dickenson, Anthony H., Wang, Fan, Malcangio, Marzia, Wood, John N.

“…Human acute and inflammatory pain requires the expression of voltage-gated sodium channel Nav1.7 but its significance for neuropathic pain is unknown. Here we…”
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Deletion of Annexin 2 Light Chain p11 in Nociceptors Causes Deficits in Somatosensory Coding and Pain Behavior by Foulkes, Thomas, Nassar, Mohammed A, Lane, Tim, Matthews, Elizabeth A, Baker, Mark D, Gerke, Volker, Okuse, Kenji, Dickenson, Anthony H, Wood, John N

“…The S100 family protein p11 (S100A10, annexin 2 light chain) is involved in the trafficking of the voltage-gated sodium channel Na(V)1.8, TWIK-related…”
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Mice lacking Kcns1 in peripheral neurons show increased basal and neuropathic pain sensitivity by Tsantoulas, Christoforos, Denk, Franziska, Signore, Massimo, Nassar, Mohammed A., Futai, Kensuke, McMahon, Stephen B.

“…Voltage-gated potassium (Kv) channels are increasingly recognised as key regulators of nociceptive excitability. Kcns1 is one of the first potassium channels…”
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