Search Results - "Nassar, Alaa"

Biotransformation and Rearrangement of Laromustine by Nassar, Alaa-Eldin F, Wisnewski, Adam V, King, Ivan

“…This review highlights the recent research into the biotransformations and rearrangement of the sulfonylhydrazine-alkylating agent laromustine. Incubation of…”
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Improving the decision-making process in the structural modification of drug candidates: enhancing metabolic stability by Nassar, Alaa-Eldin F., Kamel, Amin M., Clarimont, Caroline

“…Metabolite characterization has become one of the key drivers of the drug discovery process, helping to optimize ADME properties and increase the success rate…”
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Strategies for dealing with metabolite elucidation in drug discovery and development by Nassar, Alaa-Eldin F, Talaat, Rasmy E

“…Structural information on metabolites can be a considerable asset for enhancing and streamlining the process of developing new drug candidates. Modern…”
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Proton-Coupled Electron Transfer from Electrodes to Myoglobin in Ordered Biomembrane-like Films by Nassar, Alaa-Eldin F, Zhang, Zhe, Hu, Naifei, Rusling, James F, Kumosinski, Thomas F

“…Voltammetry and visible and infrared spectroscopy were used to explore protonation equilibria coupled to electron transfer between electrodes and the heme…”
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Improving the decision-making process in structural modification of drug candidates: reducing toxicity by NASSAR, Alaa-Eldin F, KAMEL, Amin M, CLARIMONT, Caroline

“…The rule of three, relating to activity-exposure-toxicity, presents the single most difficult challenge in the design and advancement of drug candidates to the…”
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An in Vitro Evaluation of the Victim and Perpetrator Potential of the Anticancer Agent Laromustine (VNP40101M), Based on Reaction Phenotyping and Inhibition and Induction of Cytochrome P450 Enzymes by NASSAR, Alaa-Eldin F, KING, Ivan, PARKINSON, Andrew, PARIS, Brandy L, HAUPT, Lois, NDIKUM-MOFFOR, Florence, CAMPBELL, Rebecca, USUKI, Etsuko, SKIBBE, Jennifer, BROBST, Dan, OGILVIE, Brian W

“…Laromustine (VNP40101M, also known as Cloretazine) is a novel sulfonylhydrazine alkylating (anticancer) agent. Laromustine generates two types of reactive…”
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Enhanced electron transfer for myoglobin in surfactant films on electrodes by Rusling, James F, Nassar, Alaa Eldin F

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Electron Transfer from Electrodes to Myoglobin: Facilitated in Surfactant Films and Blocked by Adsorbed Biomacromolecules by Nassar, Alaa-Eldin F, Willis, William S, Rusling, James F

“…In previous work, greatly enhanced rates of electron transfer were found for myoglobin (Mb) in ordered films of surfactants on pyrolytic graphite (PG)…”
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Symbiotic impact of carbon quantum dots on microstructural development and mechanical behaviour of cement mortars by Jayachandra, Reddy, Y.Ramalinga, Nassar, Alaa Hussein, Kangda, Mohd Zain, Yashwanth, H.J., Khan, Mohammad Amir, Asiri, Abdullah Naser M., Islam, Saiful, Algburi, Sameer

“…Carbon Quantum Dots (CQDs) are a new environmentally pleasant material of the carbon family that has gained great interest in construction engineering due to…”
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Catalytic Reduction of Organohalide Pollutants by Myoglobin in a Biomembrane-like Surfactant Film by Nassar, Alaa-Eldin F, Bobbitt, James M, Stuart, James D, Rusling, James F

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Electron Transfer between Electrodes and Heme Proteins in Protein−DNA Films by Nassar, Alaa-Eldin F, Rusling, James F, Nakashima, Naotoshi

“…Electrodes with immobilized DNA can be used as DNA sensors, and for many other applications. Herein we report stable films of calf thymus (CT) double stranded…”
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Molecular detection of two virulence factors of Pseudomonas aeruginosa isolated from burn patients by al-Maliki, Haydar Khamis, Degaim, Zaynab Dakhil, Nasir, Ahmad A., Nassar, Ala Mithqal

“…The present study aimed to identify two virulence genes in P. aeruginosa isolated from infected burn wound. Out of 70 burn swabs, 54 (77%) showed positive…”
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Separation of Chemical Warfare Agent Degradation Products by the Reversal of Electroosmotic Flow in Capillary Electrophoresis by Nassar, Alaa-Eldin F, Lucas, Samuel V, Jones, William R, Hoffland, Lynn D

“…We report the development of analyses for nerve agent degradation products or related species by the reversal of electroosmotic flow in capillary…”
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Determination of Chemical Warfare Agent Degradation Products at Low-Part-per-Billion Levels in Aqueous Samples and Sub-Part-per-Million Levels in Soils Using Capillary Electrophoresis by Nassar, Alaa-Eldin F, Lucas, Samuel V, Hoffland, Lynn D

“…A significant enhancement in the method detection limits is observed in the analysis of chemical warfare agent (CWA) degradation products in environmental…”
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Quantitative Analysis of Chemical Warfare Agent Degradation Products in Reaction Masses Using Capillary Electrophoresis by Nassar, Alaa-Eldin F, Lucas, Samuel V, Myler, Craig A, Jones, William R, Campisano, Michael, Hoffland, Lynn D

“…Quantitative methods have been developed for the analysis of chemical warfare agent degradation products in reaction masses using capillary electrophoresis…”
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Drug interactions: concerns and current approaches by Nassar, Alaa-Eldin F, Talaat, Rasmy E, Tokuno, Hajime

“…Following the recent withdrawal of several prominent drugs from US and European markets because of detrimental drug-drug interactions, metabolic drug…”
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Electrochemistry of cast films of ferredoxin and lipid bilayers on electrodes by Nassar, Alaa-Eldin F., Rusling, James F., Tominaga, Masato, Yanagimoto, Junko, Nakashima, Naotoshi

“…Structural stability and electrochemistry of Chlorella ferredoxin immobilized in a cast film of molecular bilayer membranes of a biological lipid,…”
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Incorporation and Direct Electron Transfer of Chlorella Ferredoxin in the Bilayer Films of Cationic Lipids on Electrodes by Tominaga, Masato, Yanagimoto, Junko, Nassar, Alaa-Eldin F, Rusling, James F, Nakashima, Naotoshi

“…Chlorella ferredoxin in solution was found to be incorporated into the cast films of ammonium lipids on basal plane pyrolytic graphite (BPG) electrodes via ion…”
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Electron Transfer Rates in Electroactive Films from Normal Pulse Voltammetry. Myoglobin-Surfactant Films by Rusling, James F, Nassar, Alaa-Eldin F

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Salt and pH effects on electrochemistry of myoglobin in thick films of a bilayer-forming surfactant by Nassar, Alaa-Eldin F., Rusling, James F., Kumosinski, Thomas F.

“…Salt concentration and pH of external solutions were shown to control the electrochemistry of the heme protein myoglobin (MbFe(III)H 2O) in stable, ordered…”
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