Gastrointestinal Microflora Studies in Late-Onset Autism

Some cases of late-onset (regressive) autism may involve abnormal flora because oral vancomycin, which is poorly absorbed, may lead to significant improvement in these children. Fecal flora of children with regressive autism was compared with that of control children, and clostridial counts were hig...

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Bibliographic Details
Published in:	Clinical infectious diseases Vol. 35; no. Supplement-1; pp. S6 - S16
Main Authors:	Finegold, Sydney M., Molitoris, Denise, Song, Yuli, Liu, Chengxu, Vaisanen, Marja-Liisa, Bolte, Ellen, McTeague, Maureen, Sandler, Richard, Wexler, Hannah, Marlowe, Elizabeth M., Collins, Matthew D., Lawson, Paul A., Summanen, Paula, Baysallar, Mehmet, Tomzynski, Thomas J., Read, Erik, Johnson, Eric, Rolfe, Rial, Nasir, Palwasha, Shah, Haroun, Haake, David A., Manning, Patricia, Kaul, Ajay
Format:	Journal Article Conference Proceeding
Language:	English
Published:	Chicago, IL The University of Chicago Press 01-09-2002 University of Chicago Press
Subjects:	Age of Onset Anaerobic bacteria Antimicrobials Autistic disorder Autistic Disorder - microbiology Autistic Disorder - physiopathology Bacteria Biological and medical sciences Child Child clinical studies Child growth Child health services Child, Preschool Children Clostridium Clostridium - classification Clostridium - isolation & purification Developmental disorders Digestive System - microbiology Flora Humans Infantile autism Medical sciences Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Small intestine Human Eubacteriales Pathogenesis Clostridium difficile Gut Clostridiales Microflora Developmental disorder Peptococcaceae Gastrointestinal Autism Microbiological investigation Clostridiaceae Ruminococcus Bacteria Feces Child
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Summary:	Some cases of late-onset (regressive) autism may involve abnormal flora because oral vancomycin, which is poorly absorbed, may lead to significant improvement in these children. Fecal flora of children with regressive autism was compared with that of control children, and clostridial counts were higher. The number of clostridial species found in the stools of children with autism was greater than in the stools of control children. Children with autism had 9 species of Clostridium not found in controls, whereas controls yielded only 3 species not found in children with autism. In all, there were 25 different clostridial species found. In gastric and duodenal specimens, the most striking finding was total absence of non—spore-forming anaerobes and microaerophilic bacteria from control children and significant numbers of such bacteria from children with autism. These studies demonstrate significant alterations in the upper and lower intestinal flora of children with late-onset autism and may provide insights into the nature of this disorder.
Bibliography:	istex:A9FABEEBBF94A8B65B379F4FB4430F83F92C0CDD ark:/67375/HXZ-JWP1F5JD-8 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	1058-4838 1537-6591
DOI:	10.1086/341914