Search Results - "Nasir, K"

Allosteric Inhibition of a Semaphorin 4D Receptor Plexin B1 by a High-Affinity Macrocyclic Peptide by Matsunaga, Yukiko, Bashiruddin, Nasir K, Kitago, Yu, Takagi, Junichi, Suga, Hiroaki

“…Semaphorin axonal guidance factors are multifunctional proteins that play important roles in immune response, cancer cell proliferation, and organogenesis,…”
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Construction and screening of vast libraries of natural product-like macrocyclic peptides using in vitro display technologies by Bashiruddin, Nasir K, Suga, Hiroaki

“…•Ribosomal expression of vast libraries of up to trillions of macrocyclic peptides.•Rapid screening of bioactive molecules by in vitro display…”
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Cardio-renal safety of non-steroidal anti-inflammatory drugs by Radi, Zaher A., Khan, K. Nasir

“…Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used therapeutic class in clinical medicine. These are sub-divided based on their…”
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Development challenges associated with rAAV-based gene therapies by Bolt, Michael W., Brady, Joseph T., Whiteley, Lawrence O., Khan, K. Nasir

“…The number of gene therapies in development continues to increase, as they represent a novel method to treat, and potentially cure, many diseases. Gene…”
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Development of cyclic peptides with potent in vivo osteogenic activity through RaPID-based affinity maturation by Bashiruddin, Nasir K., Hayashi, Mikihito, Nagano, Masanobu, Wu, Yan, Matsunaga, Yukiko, Takagi, Junichi, Nakashima, Tomoki, Suga, Hiroaki

“…Osteoporosis is caused by a disequilibrium between bone resorption and bone formation. Therapeutics for osteoporosis can be divided into antiresorptives that…”
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Mechanistic Investigation of Bone Marrow Suppression Associated with Palbociclib and its Differentiation from Cytotoxic Chemotherapies by Hu, Wenyue, Sung, Tae, Jessen, Bart A, Thibault, Stephane, Finkelstein, Martin B, Khan, Nasir K, Sacaan, Aida I

“…Palbociclib (PD-0332991) is the first selective cyclin-dependent kinase (CDK) 4/6 inhibitor approved for metastatic breast cancer. Hematologic effects,…”
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Facile Synthesis of Dimeric Thioether–Macrocyclic Peptides with Antibody-like Affinity against Plexin-B1 by Bashiruddin, Nasir K, Matsunaga, Yukiko, Nagano, Masanobu, Takagi, Junichi, Suga, Hiroaki

“…Macrocyclic peptides have gained increasing attention due to their ease of discovery through various in vitro display platforms as well as their potential in…”
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De novo Fc-based receptor dimerizers differentially modulate PlexinB1 function by Sugano-Nakamura, Nozomi, Matoba, Kyoko, Hirose, Mika, Bashiruddin, Nasir K., Matsunaga, Yukiko, Yamashita, Keitaro, Hirata, Kunio, Yamamoto, Masaki, Arimori, Takao, Suga, Hiroaki, Takagi, Junichi

“…Signaling by single-pass transmembrane receptors often involves a formation of ligand-induced receptor dimers with particular conformation, and bivalent…”
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Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins by Mihara, Emiko, Watanabe, Satoshi, Bashiruddin, Nasir K., Nakamura, Nozomi, Matoba, Kyoko, Sano, Yumi, Maini, Rumit, Yin, Yizhen, Sakai, Katsuya, Arimori, Takao, Matsumoto, Kunio, Suga, Hiroaki, Takagi, Junichi

“…Protein engineering has great potential for devising multifunctional recombinant proteins to serve as next-generation protein therapeutics, but it often…”
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Myocarditis in Cynomolgus Monkeys Following Treatment with Immune Checkpoint Inhibitors by Ji, Changhua, Roy, Marc D, Golas, Jonathan, Vitsky, Allison, Ram, Sripad, Kumpf, Steven W, Martin, Matthew, Barletta, Frank, Meier, William A, Hooper, Andrea T, Sapra, Puja, Khan, Nasir K, Finkelstein, Martin, Guffroy, Magali, Buetow, Bernard S

“…Immune checkpoint inhibitors (ICI) targeting PD1, PDL1, or CTLA4 are associated with immune-related adverse events (irAE) in multiple organ systems including…”
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Non-clinical combination toxicology studies: strategy, examples and future perspective by Sacaan, Aida, Hashida, Satoko Nonaka, Khan, Nasir K.

“…Over the last decade, combination of drugs in all stages of pharmaceutical development has accelerated availability of promising new therapies for difficult to…”
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Impact of coronary artery calcium on coronary heart disease events in individuals at the extremes of traditional risk factor burden: the Multi-Ethnic Study of Atherosclerosis by Silverman, Michael G, Blaha, Michael J, Krumholz, Harlan M, Budoff, Matthew J, Blankstein, Ron, Sibley, Christopher T, Agatston, Arthur, Blumenthal, Roger S, Nasir, Khurram

“…We sought to evaluate the impact of coronary artery calcium (CAC) in individuals at the extremes of risk factor (RF) burden. 6698 individuals from the…”
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Enzalutamide and Apalutamide: In Vitro Chemical Reactivity Studies and Activity in a Mouse Drug Allergy Model by Ji, Changhua, Guha, Mausumee, Zhu, Xu, Whritenour, Jessica, Hemkens, Michelle, Tse, Susanna, Walker, Gregory S, Evans, Ellen, Khan, Nasir K, Finkelstein, Martin B, Callegari, Ernesto, Obach, R. Scott

“…Enzalutamide and apalutamide are two androgen receptor inhibitors approved for the treatment of castration-resistant prostate cancer (CRPC) and nonmetastatic…”
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Translation of nonclinical to clinical safety findings for 27 biotherapeutics by Leach, Michael W., Rana, Payal, Hu, Wenyue, Mittapalli, Rajendar K., Pinkstaff, Jason, Potter, David, Qiu, Xing Min, Ramaiah, Lila, Rohde, Cynthia, Xia, Feng, Khan, K. Nasir

“…Human adverse drug reactions (ADRs), and in vivo nonclinical adverse and nonadverse findings, were identified in 27 biotherapeutic programs and placed into…”
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Changes in optical characteristics induced by polymer blending in printed colloidal quantum dots microlasers by Wan, Lei, Chen, Cong, Zhu, Junfeng, Nasir, K T Abdul, Cui, Qingyu, Chen, Zhenshi, Yoshioka, Hiroaki, Liu, Weiping, Oki, Yuji, Li, Zhaohui

“…On-chip microlasers are desirable to meet the different control requirements and unique demands in different application scenarios. In this work, we obtained…”
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Central nervous system tumors in 2-year rat carcinogenicity studies: perspectives on human risk assessment by Sacaan, Aida, Thibault, Stephane, Khan, K. Nasir

“…Rodent in vivo carcinogenicity bioassays are required for human risk assessment and have been utilized in this capacity for decades. Accordingly, there is an…”
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The Role of Lipid-Lowering Therapy in Post-Stroke Patients: Update and Recommendations by Avenatti, E., Carrasco-Avila, J. A., Heidari, B., Hagan, K., Taha, M., Nasir, K.

“…Purpose of Review Stroke is the second leading cause of death and disability-adjusted life years worldwide, and the global lifetime risk of stroke is rising…”
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Flame synthesis of graphene films in open environments by Memon, Nasir K., Tse, Stephen D., Al-Sharab, Jafar F., Yamaguchi, Hisato, Goncalves, Alem-Mar B., Kear, Bernard H., Jaluria, Yogesh, Andrei, Eva Y., Chhowalla, Manish

“…Few-layer graphene is grown on copper and nickel substrates at high rates using a novel flame synthesis method in open-atmosphere environments. Transmittance…”
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Diagnostic Evaluation of Autism Spectrum Disorder in Pediatric Primary Care by Nasir, Arwa K, Strong-Bak, Whitney, Bernard, Marie

“…Children with autism spectrum disorder (ASD) continue to experience significant delays in diagnosis and interventions. One of the main factors contributing to…”
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The metabolic syndrome and diabetes mellitus as predictors of thoracic aortic calcification as detected by non-contrast computed tomography in the Multi-Ethnic Study of Atherosclerosis by Katz, R., Budoff, M. J., O'Brien, K. D., Wong, N. D., Nasir, K.

“…Aims The metabolic syndrome (MetS) is a clustering of low levels of HDL cholesterol, hyperglycaemia, high waist circumference, hypertension and elevated…”
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