The efficacy of pentazocine + diclofenac versus paracetamol + diclofenac for post- caesarean section analgesia

The efficacy of pentazocine + diclofenac versus paracetamol + diclofenac for post- caesarean section analgesia

Background: The most common major obstetric procedure is caesarean section (CS) and one of the greatest concerns for women after CS is to have optimal pain relief. Aim: This study aims to compare the efficacy of pentazocine + diclofenac and paracetamol + diclofenac on post-operative analgesia after...

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Bibliographic Details
Published in:The Nigerian postgraduate medical journal Vol. 28; no. 3; pp. 187 - 192
Main Authors: Garba, Jamila, Panti, Abubakar, Nnadi, Daniel, Ango, Ibrahim, Tunau, Karima, Bello, Saratu, Zubairu, Saad, Nasir, Asmau'u, Ibrahim, Rukayya
Format: Journal Article
Language:English
Published: Nigeria Wolters Kluwer India Pvt. Ltd 01-07-2021
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Wolters Kluwer Medknow Publications
Subjects:
Acetaminophen
Acetaminophen - therapeutic use
Analgesia
Analgesics
Analgesics, Opioid - therapeutic use
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
caesarean section
Cesarean section
Cesarean Section - adverse effects
Comparative analysis
Complications and side effects
Diclofenac
Diclofenac - therapeutic use
Dosage and administration
Double-Blind Method
Drug therapy
Drug therapy, Combination
Female
Humans
Methods
Nigeria
Nonsteroidal anti-inflammatory drugs
Pain
Pain, Postoperative
Pain, Postoperative - drug therapy
Pain, Postoperative - etiology
Pain, Postoperative - prevention & control
paracetamol
Patient outcomes
Pentazocine
Pentazocine - therapeutic use
post-operative pain relief
Pregnancy
Risk factors
Single-Blind Method
Nigeria
Caesarean section
post-operative pain relief
paracetamol
diclofenac
pentazocine
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Summary:Background: The most common major obstetric procedure is caesarean section (CS) and one of the greatest concerns for women after CS is to have optimal pain relief. Aim: This study aims to compare the efficacy of pentazocine + diclofenac and paracetamol + diclofenac on post-operative analgesia after CS. Methodology: This was a single-blind, randomised trial. Pregnant women that had CS were randomized into two groups. Group A received intramuscular pentazocine + rectal diclofenac postoperatively. Group B received intramuscular paracetamol + rectal diclofenac postoperatively. Post-operative pain was assessed by numeric rating scale at 1 h after the surgery, at 6 h, 12 h and 24 h. The result obtained was analysed using SPSS Version 22 and P < 0.05 was considered statistically significant. Results: The median pain scores in both groups ranged from 2 to 3 across all periods of assessment. The pain relief was slightly better in the pentazocine + diclofenac group with no significant difference in the pain score between the two groups at all periods of assessment. The satisfaction level was good in 66.3% and 69.5% of the participants in the pentazocine + diclofenac and paracetamol + diclofenac group respectively but the difference was not statistically significant (χ2 = 4.14, P = 0. 12). Nausea, vomiting and drowsiness were significantly more in the pentazocine + diclofenac combination (P < 0.001). Conclusion: Both combination of analgesics provided adequate analgesia but pentazocine + diclofenac combination had better pain relief but was more associated with side effects.
Bibliography:ObjectType-Article-1
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content type line 23
ISSN:1117-1936
2468-6875
DOI:10.4103/npmj.npmj_404_21