Search Results - "Nashimoto, Masayuki"

TRUE Gene Silencing by Nashimoto, Masayuki

“…TRUE gene silencing is an RNA-mediated gene expression control technology and is termed after tRNase Z -utilizing efficacious gene silencing. In this review, I…”
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Large-Scale Isolation of Three O-Methyl Anthocyanins from Bilberry (Vaccinium myrtillus L.) Extract by Ichiyanagi, Takashi, Kashiwada, Yoshiki, Nashimoto, Masayuki

“…Three O-methyl anthocyanidin 3-O-β-D-glucopyranosides were isolated from bilberry extract on a large-scale basis together with two non O-methyl analogues…”
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RNA-hydrolyzing activity of metallo-β-lactamase IMP-1 by Kato, Yoshiki, Takahashi, Masayuki, Seki, Mineaki, Nashimoto, Masayuki, Shimizu-Ibuka, Akiko

“…Metallo-β-lactamases (MBLs) hydrolyze a wide range of β-lactam antibiotics. While all MBLs share a common αβ/βα-fold, there are many other proteins with the…”
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Polypeptide N-acetylgalactosaminyltransferase-15 regulates adipogenesis in human SGBS cells by Takahashi, Asuka, Koike, Ryo, Watanabe, Shota, Kuribayashi, Kyoko, Wabitsch, Martin, Miyamoto, Masahiko, Komuro, Akihiko, Seki, Mineaki, Nashimoto, Masayuki, Shimizu-Ibuka, Akiko, Yamashita, Kikuji, Iwata, Takeo

“…Adipogenesis involves intricate molecular mechanisms regulated by various transcription factors and signaling pathways. In this study, we aimed to identify…”
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Perturbing the Normal Level of SIDT1 Suppresses the Naked ASO Effect by Takahashi, Masayuki, Seki, Mineaki, Nashimoto, Masayuki, Kabuta, Tomohiro

“…Although antisense oligonucleotide (ASO) therapeutics can be taken up by living cells without carrier molecules, a large part of incorporated ASOs are trapped…”
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Modulation of gene expression by human cytosolic tRNase Z(L) through 5'-half-tRNA by Elbarbary, Reyad A, Takaku, Hiroaki, Uchiumi, Naoto, Tamiya, Hiroko, Abe, Mayumi, Takahashi, Masayuki, Nishida, Hiroshi, Nashimoto, Masayuki

“…A long form (tRNase Z(L)) of tRNA 3' processing endoribonuclease (tRNase Z, or 3' tRNase) can cleave any target RNA at any desired site under the direction of…”
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Regulation of CXCL12 expression by canonical Wnt signaling in bone marrow stromal cells by Tamura, Masato, Sato, Mari M., Nashimoto, Masayuki

“…CXCL12 (stromal cell-derived factor-1, SDF-1), produced by stromal and endothelial cells including cells of the bone marrow, binds to its receptor CXCR4 and…”
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Growth inhibition of head and neck squamous cell carcinoma cells by sgRNA targeting the cyclin D1 mRNA based on TRUE gene silencing by Iizuka, Satoshi, Oridate, Nobuhiko, Nashimoto, Masayuki, Fukuda, Satoshi, Tamura, Masato

“…Head and neck squamous cell carcinoma (HNSCC) exhibits increased expression of cyclin D1 (CCND1). Previous studies have shown a correlation between poor…”
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TRUE Gene Silencing: Screening of a Heptamer-type Small Guide RNA Library for Potential Cancer Therapeutic Agents by Haino, Arisa, Ishikawa, Tatsuya, Seki, Mineaki, Nashimoto, Masayuki

“…TRUE gene silencing (termed after tRNase Z(L)-utilizing efficacious gene silencing) is one of the RNA-directed gene silencing technologies, which utilizes an…”
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Potential physiological roles of the 31/32-nucleotide Y4-RNA fragment in human plasma by Ninomiya, Sho, Ishikawa, Tatsuya, Takahashi, Masayuki, Seki, Mineaki, Nashimoto, Masayuki

“…The 31- and 32-nt 5′-fragments of Y4-RNA (Y4RNAfr) exist abundantly in human plasma. The Y4RNAfr can function as 5′-half-tRNA-type sgRNA for tRNase ZL,…”
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Bone morphogenetic protein-2 down-regulates miR-206 expression by blocking its maturation process by Sato, Mari M., Nashimoto, Masayuki, Katagiri, Takenobu, Yawaka, Yasutaka, Tamura, Masato

“…MicroRNAs (miRNAs) are small non-coding RNAs that are emerging as important post-transcriptional gene regulators. miR-206 is unique in that it is expressed…”
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The heptamer sgRNA targeting the human OCT4 mRNA can upregulate the OCT4 expression by Nozaki, Tadasuke, Takahashi, Masayuki, Ishikawa, Tatsuya, Haino, Arisa, Seki, Mineaki, Kikuchi, Hidetomo, Yuan, Bo, Nashimoto, Masayuki

“…TRUE gene silencing is one of the gene suppression technologies. This technology exploits the enzymatic property of the tRNA 3′ processing endoribonuclease…”
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Dual activity of PNGM-1 pinpoints the evolutionary origin of subclass B3 metallo-β-lactamases: a molecular and evolutionary study by Lee, Jung Hun, Takahashi, Masayuki, Jeon, Jeong Ho, Kang, Lin-Woo, Seki, Mineaki, Park, Kwang Seung, Hong, Myoung-Ki, Park, Yoon Sik, Kim, Tae Yeong, Karim, Asad Mustafa, Lee, Jung-Hyun, Nashimoto, Masayuki, Lee, Sang Hee

“…Resistance to β-lactams is one of the most serious problems associated with Gram-negative infections. β-Lactamases are able to hydrolyze β-lactams such as…”
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Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit by Muhs, Margarita, Yamamoto, Hiroshi, Ismer, Jochen, Takaku, Hiroaki, Nashimoto, Masayuki, Uchiumi, Toshio, Nakashima, Nobuhiko, Mielke, Thorsten, Hildebrand, Peter W., Nierhaus, Knud H., Spahn, Christian M. T.

“…Some viruses exploit internal initiation for their propagation in the host cell. This type of initiation is facilitated by structured elements (internal…”
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Expanding the utility of heptamer-type sgRNA for TRUE gene silencing by Sano, Takako, Takahashi, Masayuki, Nozaki, Tadasuke, Takahashi, Yoshiaki, Tamura, Masato, Nashimoto, Masayuki

“…► TRUE gene silencing is a novel technology for suppressing gene expression. ► This is based on the property that tRNase ZL can cleave any target RNA under the…”
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Potential small guide RNAs for tRNase ZL from human plasma, peripheral blood mononuclear cells, and cultured cell lines by Ninomiya, Sho, Kawano, Mitsuoki, Abe, Takashi, Ishikawa, Tatsuya, Takahashi, Masayuki, Tamura, Masato, Takahashi, Yoshiaki, Nashimoto, Masayuki

“…Several pieces of evidence suggest that small RNA degradation products together with tRNase ZL appear to form another layer of the whole gene regulatory…”
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The Y4-RNA fragment, a potential diagnostic marker, exists in saliva by Ishikawa, Tatsuya, Haino, Arisa, Seki, Mineaki, Terada, Hiroshi, Nashimoto, Masayuki

“…The 94-nt full-length Y4-RNA is thought to have roles in the initiation of DNA replication and RNA quality control. Although its 31/32-nt fragment also exists…”
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Crystal Structure of the tRNA 3′ Processing Endoribonuclease tRNase Z from Thermotoga maritima by Ishii, Ryohei, Minagawa, Asako, Takaku, Hiroaki, Takagi, Masamichi, Nashimoto, Masayuki, Yokoyama, Shigeyuki

“…The maturation of the tRNA 3′ end is catalyzed by a tRNA 3′ processing endoribonuclease named tRNase Z (RNase Z or 3′-tRNase) in eukaryotes, Archaea, and some…”
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A Novel Endonucleolytic Mechanism to Generate the CCA 3′ Termini of tRNA Molecules in Thermotoga maritima by Minagawa, Asako, Takaku, Hiroaki, Takagi, Masamichi, Nashimoto, Masayuki

“…The tRNA 3′-terminal CCA sequence is essential for aminoacylation of the tRNAs and for translation on the ribosome. The tRNAs are transcribed as larger…”
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The 31-nucleotide Y4-RNA fragment in plasma is a potential novel biomarker by Ishikawa, Tatsuya, Haino, Arisa, Seki, Mineaki, Kurihara, Taro, Hirose, Takayuki, Imai, Yosuke, Ishiguro, Takuro, Chou, Takaaki, Toshima, Muneatsu, Terada, Hiroshi, Nashimoto, Masayuki

“…The 31- and 32-nt 5′-fragment of Y4-RNA (Y4RNAfr) exists abundantly in human peripheral blood plasma. Although physiological roles of the plasma Y4RNAfr are…”
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