Search Results - "Nash, Samuel"
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Amorphous solid dispersions: Utilization and challenges in preclinical drug development within AstraZeneca
Published in International journal of pharmaceutics (25-02-2022)“…[Display omitted] The poor aqueous solubility of many active pharmaceutical ingredients (APIs) dominates much of the early drug development portfolio and poses…”
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Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase
Published in Journal of medicinal chemistry (09-12-2021)“…Aberrant activity of the histone methyltransferase polycomb repressive complex 2 (PRC2) has been linked to several cancers, with small-molecule inhibitors of…”
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Far from barbaric: Re-assessing the sophistication of merovingian metalworking
Published in JOM (1989) (01-08-2005)“…The seven axes sampled of possible Merovingian date belonged to two categories: three were belt axes for general use (1924.02.0026,0027 (Figure 6), and 0315)…”
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Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS G12C with Demonstrable CNS Penetration
Published in Journal of medicinal chemistry (13-07-2023)“…The glycine to cysteine mutation at codon 12 of Kirsten rat sarcoma (KRAS) represents an Achilles heel that has now rendered this important GTPase druggable…”
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Metal-forming practices among the seventeenth century Illinois, 1640–1682
Published in Materials characterization (01-10-2000)“…When European copper-based metal trade goods, primarily kettles, first became available to native Americans early in the contact period, they frequently…”
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To The Editor Of The Times
Published in Times (London, England : 1788) (27-08-1822)Get full text
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CAN WE LEARN TO GOVERN? ESTABLISHING SCHOOLS OF CHOICE
Published in American journal of orthopsychiatry (01-07-1970)“…Our society's startling success in solving the problems of production, an epochal human achievement, has thrust us into an era of great transition. The purpose…”
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Renal biopsy as an aid to diagnosis in the cat and dog
Published 01-01-1984“…During the last 30 years needle biopsy has become a standard procedure in the diagnosis of human renal disease, particularly diffuse disorders like…”
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Dissertation