Search Results - "Nash, Kevin R."

Neuroinflammation and fractalkine signaling in Alzheimer's disease by Finneran, Dylan J, Nash, Kevin R

“…Alzheimer's disease (AD) is a progressive, neurodegenerative disorder, and the most common form of dementia. As the understanding of AD has progressed, it is…”
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T cell infiltration and upregulation of MHCII in microglia leads to accelerated neuronal loss in an α-synuclein rat model of Parkinson's disease by Subbarayan, Meena S, Hudson, Charles, Moss, Lauren D, Nash, Kevin R, Bickford, Paula C

“…Parkinson's disease (PD) is the second most prevalent movement disorder characterized by up to 80% loss of dopamine (DA) neurons and accumulation of Lewy body…”
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Reelin Signaling in Neurodevelopmental Disorders and Neurodegenerative Diseases by Joly-Amado, Aurelie, Kulkarni, Neel, Nash, Kevin R

“…Reelin is an extracellular matrix glycoprotein involved in neuronal migration during embryonic brain development and synaptic plasticity in the adult brain…”
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Lung infection by Pseudomonas aeruginosa induces neuroinflammation and blood-brain barrier dysfunction in mice by Villalba, Nuria, Ma, Yonggang, Gahan, Sarah A, Joly-Amado, Aurelie, Spence, Sam, Yang, Xiaoyuan, Nash, Kevin R, Yuan, Sarah Y

“…Severe lung infection can lead to brain dysfunction and neurobehavioral disorders. The mechanisms that regulate the lung-brain axis of inflammatory response to…”
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Therapeutic Delivery of Soluble Fractalkine Ameliorates Vascular Dysfunction in the Diabetic Retina by Rodriguez, Derek, Church, Kaira A, Smith, Chelsea T, Vanegas, Difernando, Cardona, Sandra M, Muzzio, Isabel A, Nash, Kevin R, Cardona, Astrid E

“…Diabetic retinopathy (DR)-associated vision loss is a devastating disease affecting the working-age population. Retinal pathology is due to leakage of serum…”
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Fractalkine isoforms differentially regulate microglia-mediated inflammation and enhance visual function in the diabetic retina by Rodriguez, Derek, Church, Kaira A, Pietramale, Alicia N, Cardona, Sandra M, Vanegas, Difernando, Rorex, Colin, Leary, Micah C, Muzzio, Isabel A, Nash, Kevin R, Cardona, Astrid E

“…Diabetic retinopathy (DR) affects about 200 million people worldwide, causing leakage of blood components into retinal tissues, leading to activation of…”
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CNS-Wide over Expression of Fractalkine Improves Cognitive Functioning in a Tauopathy Model by Finneran, Dylan J., Morgan, Dave, Gordon, Marcia N., Nash, Kevin R.

“…Accumulating evidence increasingly implicates regulation of neuroinflammation as a potential therapeutic target in Alzheimer’s disease and other…”
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Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology by Sandusky-Beltran, Leslie A, Kovalenko, Andrii, Placides, Devon S, Ratnasamy, Kevin, Ma, Chao, Hunt, Jr, Jerry B, Liang, Huimin, Calahatian, John Ivan T, Michalski, Camilla, Fahnestock, Margaret, Blair, Laura J, Darling, April L, Baker, Jeremy D, Fontaine, Sarah N, Dickey, Chad A, Gamsby, Joshua J, Nash, Kevin R, Abner, Erin, Selenica, Maj-Linda B, Lee, Daniel C

“…Tauopathies display a spectrum of phenotypes from cognitive to affective behavioral impairments; however, mechanisms promoting tau pathology and how tau…”
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Toward Development of Neuron Specific Transduction After Systemic Delivery of Viral Vectors by Finneran, Dylan J, Njoku, Ikenna P, Flores-Pazarin, Diego, Ranabothu, Meghana R, Nash, Kevin R, Morgan, David, Gordon, Marcia N

“…Widespread transduction of the CNS with a single, non-invasive systemic injection of adeno-associated virus is now possible due to the creation of blood-brain…”
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Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy by Hunt, Jr, Jerry B, Nash, Kevin R, Placides, Devon, Moran, Peter, Selenica, Maj-Linda B, Abuqalbeen, Firas, Ratnasamy, Kevin, Slouha, Nina, Rodriguez-Ospina, Santiago, Savlia, Miloni, Ranaweera, Yashobha, Reid, Patrick, Dickey, Chad A, Uricia, Rodrigo, Yang, Clement G Y, Sandusky, Leslie A, Gordon, Marcia N, Morgan, Dave, Lee, Daniel C

“…Tau accumulation remains one of the closest correlates of neuronal loss in Alzheimer's disease. In addition, tau associates with several other…”
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Diverse activation of microglia by chemokine (C-C motif) ligand 2 overexpression in brain by Selenica, Maj-Linda B, Alvarez, Jennifer A, Nash, Kevin R, Lee, Daniel C, Cao, Chuanhai, Lin, Xiaoyang, Reid, Patrick, Mouton, Peter R, Morgan, Dave, Gordon, Marcia N

“…The chemokine (C-C motif) ligand 2 (CCL2) is a monocyte chemoattractant protein that mediates macrophage recruitment and migration during peripheral and…”
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Intracranial injection of AAV expressing NEP but not IDE reduces amyloid pathology in APP+PS1 transgenic mice by Carty, Nikisha, Nash, Kevin R, Brownlow, Milene, Cruite, Dana, Wilcock, Donna, Selenica, Maj-Linda B, Lee, Daniel C, Gordon, Marcia N, Morgan, Dave

“…The accumulation of β-amyloid peptides in the brain has been recognized as an essential factor in Alzheimer's disease pathology. Several proteases, including…”
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Spermidine/spermine-N 1 -acetyltransferase ablation impacts tauopathy-induced polyamine stress response by Sandusky-Beltran, Leslie A, Kovalenko, Andrii, Ma, Chao, Calahatian, John Ivan T, Placides, Devon S, Watler, Mallory D, Hunt, Jerry B, Darling, April L, Baker, Jeremy D, Blair, Laura J, Martin, Mackenzie D, Fontaine, Sarah N, Dickey, Chad A, Lussier, April L, Weeber, Edwin J, Selenica, Maj-Linda B, Nash, Kevin R, Gordon, Marcia N, Morgan, Dave, Lee, Daniel C

“…Tau stabilizes microtubules; however, in Alzheimer's disease (AD) and tauopathies, tau becomes hyperphosphorylated, aggregates, and results in neuronal death…”
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371 Fractalkine isoforms using gene therapy differentially regulate microglia activation and vascular damage in the diabetic retina by Rodriguez, Derek, Church, Kaira A., Pietramale, Alicia N., Cardona, Sandra M., Vanegas, Difernando, Muzzio, Isabel A., Nash, Kevin R., Cardona, Astrid E.

“…OBJECTIVES/GOALS: Retinal inflammation caused by the activation of resident macrophages (microglia) during diabetes exacerbates glial cell dysfunction,…”
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CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases by Subbarayan, Meena S., Joly-Amado, Aurelie, Bickford, Paula C., Nash, Kevin R.

“…Neuroinflammation was initially thought of as a consequence of neurodegenerative disease pathology, but more recently it is becoming clear that it plays a…”
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Adenylyl cyclase 2 expression and function in neurological diseases by Gray, Marsilla, Nash, Kevin R., Yao, Yao

“…Adenylyl cyclases (Adcys) catalyze the formation of cAMP, a secondary messenger essential for cell survival and neurotransmission pathways in the CNS. Adcy2,…”
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Recovery of Angelman syndrome rat deficits with UBE3A protein supplementation by Dodge, Andie, Morrill, Nicole K., Weeber, Edwin J., Nash, Kevin R.

“…We recently generated a novel Angelman syndrome (AS) rat model with a complete Ube3a gene deletion, that recapitulates the loss of UBE3A protein and shows…”
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Reelin central fragment supplementation improves cognitive deficits in a mouse model of Fragile X Syndrome by Morrill, Nicole K., Joly-Amado, Aurelie, Li, Qingyou, Prabhudeva, Sahana, Weeber, Edwin J., Nash, Kevin R.

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Small-Scale Recombinant Adeno-Associated Virus Purification by Burger, Corinna, Nash, Kevin R

“…Recombinant adeno-associated virus (rAAV) vectors have become increasingly popular in research and clinical trials due to their efficient gene transfer and…”
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Fractalkine Over Expression Suppresses α-Synuclein-mediated Neurodegeneration by Nash, Kevin R, Moran, Peter, Finneran, Dylan J, Hudson, Charles, Robinson, Jesse, Morgan, Dave, Bickford, Paula C

“…In Parkinson's disease, α-synuclein is known to activate microglia and this activation has been proposed as one of the mechanisms of neurodegeneration. There…”
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