Search Results - "Nash, Andrew D."

A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk by Larsson, Magnus, Rayzman, Veronika, Nolte, Marc W, Nickel, Katrin F, Björkqvist, Jenny, Jämsä, Anne, Hardy, Matthew P, Fries, Marion, Schmidbauer, Stefan, Hedenqvist, Patricia, Broomé, Michael, Pragst, Ingo, Dickneite, Gerhard, Wilson, Michael J, Nash, Andrew D, Panousis, Con, Renné, Thomas

“…Currently used anticoagulants prevent thrombosis but increase bleeding. We show an anticoagulation therapy without bleeding risk based on a plasma protease…”
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HDX-MS study on garadacimab binding to activated FXII reveals potential binding interfaces through differential solvent exposure by Ow, Saw Yen, Kapp, Eugene A, Tomasetig, Vesna, Zalewski, Anton, Simmonds, Jason, Panousis, Con, Wilson, Michael J, Nash, Andrew D, Pelzing, Matthias

“…Hageman factor (FXII) is an essential component in the intrinsic coagulation cascade and a therapeutic target for the prophylactic treatment of hereditary…”
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Therapeutic Targeting of the G-CSF Receptor Reduces Neutrophil Trafficking and Joint Inflammation in Antibody-Mediated Inflammatory Arthritis by Campbell, Ian K, Leong, David, Edwards, Kirsten M, Rayzman, Veronika, Ng, Milica, Goldberg, Gabrielle L, Wilson, Nicholas J, Scalzo-Inguanti, Karen, Mackenzie-Kludas, Charley, Lawlor, Kate E, Wicks, Ian P, Brown, Lorena E, Baz Morelli, Adriana, Panousis, Con, Wilson, Michael J, Nash, Andrew D, McKenzie, Brent S, Andrews, Arna E

“…G-CSF is a hemopoietic growth factor that has a role in steady state granulopoiesis, as well as in mature neutrophil activation and function. G-CSF- and G-CSF…”
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Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody by Broughton, Sophie E., Hercus, Timothy R., Hardy, Matthew P., McClure, Barbara J., Nero, Tracy L., Dottore, Mara, Huynh, Huy, Braley, Hal, Barry, Emma F., Kan, Winnie L., Dhagat, Urmi, Scotney, Pierre, Hartman, Dallas, Busfield, Samantha J., Owczarek, Catherine M., Nash, Andrew D., Wilson, Nicholas J., Parker, Michael W., Lopez, Angel F.

“…Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Here, we report the…”
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A potential association between IL‐3 and type I and III interferons in systemic lupus erythematosus by Oon, Shereen, Monaghan, Katherine, Ng, Milica, Hoi, Alberta, Morand, Eric, Vairo, Gino, Maraskovsky, Eugene, Nash, Andrew D, Wicks, Ian P, Wilson, Nicholas J

“…Objectives Plasmacytoid dendritic cells (pDCs), through the production of type 1 interferons (IFNs) and other cytokines, are major contributors to systemic…”
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Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells by Rigau, Marc, Ostrouska, Simone, Fulford, Thomas S, Johnson, Darryl N, Woods, Katherine, Ruan, Zheng, McWilliam, Hamish E G, Hudson, Christopher, Tutuka, Candani, Wheatley, Adam K, Kent, Stephen J, Villadangos, Jose A, Pal, Bhupinder, Kurts, Christian, Simmonds, Jason, Pelzing, Matthias, Nash, Andrew D, Hammet, Andrew, Verhagen, Anne M, Vairo, Gino, Maraskovsky, Eugene, Panousis, Con, Gherardin, Nicholas A, Cebon, Jonathan, Godfrey, Dale I, Behren, Andreas, Uldrich, Adam P

“…Gamma delta (γδ) T cells are essential to protective immunity. In humans, most γδ T cells express Vγ9Vδ2 T cell receptors (TCRs) that respond to…”
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Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1 by Redpath, Nicholas T, Xu, Yibin, Wilson, Nicholas J, Fabri, Louis J, Baca, Manuel, Andrews, Arna E, Braley, Hal, Lu, Ping, Ireland, Cheryl, Ernst, Robin E, Woods, Andrea, Forrest, Gail, An, Zhiqiang, Zaller, Dennis M, Strohl, William R, Luo, Cindy S, Czabotar, Peter E, Garrett, Thomas P J, Hilton, Douglas J, Nash, Andrew D, Zhang, Jian-Guo, Nicola, Nicos A

“…Gene deletion studies in mice have revealed critical roles for IL (interleukin)-4 and -13 in asthma development, with the latter controlling lung airways…”
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An Anti-VEGF-B Antibody Fragment Induces Regression of Pre-Existing Blood Vessels in the Rat Cornea by Irani, Yazad D, Scotney, Pierre D, Klebe, Sonja, Mortimer, Lauren A, Nash, Andrew D, Williams, Keryn A

“…We tested the ability of an antibody fragment with specificity for vascular endothelial growth factor-B (VEGF-B) to regress nascent and established corneal…”
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Anti‐βc mAb CSL311 inhibits human nasal polyp pathophysiology in a humanized mouse xenograft model by Yip, Kwok Ho, Wilson, Nicholas J., Pant, Harshita, Brown, Christopher L., Busfield, Samantha, Ng, Milica, Alhamdoosh, Monther, Woodman, Naomi, Schembri, Mark, Tumes, Damon J., Vairo, Gino, Lopez, Angel F., Nash, Andrew D., Wilson, Michael J., Grimbaldeston, Michele A., Owczarek, Catherine M.

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Role of the β Common (βc) Family of Cytokines in Health and Disease by Hercus, Timothy R, Kan, Winnie L T, Broughton, Sophie E, Tvorogov, Denis, Ramshaw, Hayley S, Sandow, Jarrod J, Nero, Tracy L, Dhagat, Urmi, Thompson, Emma J, Shing, Karen S Cheung Tung, McKenzie, Duncan R, Wilson, Nicholas J, Owczarek, Catherine M, Vairo, Gino, Nash, Andrew D, Tergaonkar, Vinay, Hughes, Timothy, Ekert, Paul G, Samuel, Michael S, Bonder, Claudine S, Grimbaldeston, Michele A, Parker, Michael W, Lopez, Angel F

“…The β common ([βc]/CD131) family of cytokines comprises granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5, all of which…”
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CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors by Panousis, Con, Dhagat, Urmi, Edwards, Kirsten M, Rayzman, Veronika, Hardy, Matthew P, Braley, Hal, Gauvreau, Gail M, Hercus, Timothy R, Smith, Steven, Sehmi, Roma, McMillan, Laura, Dottore, Mara, McClure, Barbara J, Fabri, Louis J, Vairo, Gino, Lopez, Angel F, Parker, Michael W, Nash, Andrew D, Wilson, Nicholas J, Wilson, Michael J, Owczarek, Catherine M

“…The β common-signaling cytokines interleukin (IL)-3, granulocyte-macrophage colony stimulating factor (GM-CSF) and IL-5 stimulate pro-inflammatory activities…”
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SOCS2 negatively regulates growth hormone action in vitro and in vivo by Greenhalgh, Christopher J., Rico-Bautista, Elizabeth, Lorentzon, Mattias, Thaus, Anne L., Morgan, Phillip O., Willson, Tracy A., Zervoudakis, Panagiota, Metcalf, Donald, Street, Ian, Nicola, Nicos A., Nash, Andrew D., Fabri, Louis J., Norstedt, Gunnar, Ohlsson, Claes, Flores-Morales, Amilcar, Alexander, Warren S., Hilton, Douglas J.

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SOCS2 negatively regulates growth hormone action in vitro and in vivo by Greenhalgh, Christopher J, Rico-Bautista, Elizabeth, Lorentzon, Mattias, Thaus, Anne L, Morgan, Phillip O, Willson, Tracy A, Zervoudakis, Panagiota, Metcalf, Donald, Street, Ian, Nicola, Nicos A, Nash, Andrew D, Fabri, Louis J, Norstedt, Gunnar, Ohlsson, Claes, Flores-Morales, Amilcar, Alexander, Warren S, Hilton, Douglas J

“…Mice deficient in SOCS2 display an excessive growth phenotype characterized by a 30-50% increase in mature body size. Here we show that the SOCS2-/- phenotype…”
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A cytotoxic anti-IL-3Rα antibody targets key cells and cytokines implicated in systemic lupus erythematosus by Oon, Shereen, Huynh, Huy, Tai, Tsin Yee, Ng, Milica, Monaghan, Katherine, Biondo, Mark, Vairo, Gino, Maraskovsky, Eugene, Nash, Andrew D, Wicks, Ian P, Wilson, Nicholas J

“…To date, the major target of biologic therapeutics in systemic lupus erythematosus (SLE) has been the B cell, which produces pathogenic autoantibodies…”
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Suppressor of Cytokine Signaling-3 Preferentially Binds to the SHP-2-Binding Site on the Shared Cytokine Receptor Subunit gp130 by Nicholson, Sandra E., De Souza, David, Fabri, Louis J., Corbin, Jason, Willson, Tracy A., Zhang, Jian-Guo, Silva, Anabel, Asimakis, Maria, Farley, Alison, Nash, Andrew D., Metcalf, Donald, Hilton, Douglas J., Nicola, Nicos A., Baca, Manuel

“…Suppressor of cytokine signaling-3 (SOCS-3) is one member of a family of intracellular inhibitors of signaling pathways initiated by cytokines that use, among…”
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The biology of vascular endothelial growth factor-B (VEGF-B) by Nash, Andrew D., Baca, Manuel, Wright, Christine, Scotney, Pierre D.

“…The formation of new blood vessels (angiogenesis) is critical for both embryonic development and a variety of normal postnatal physiological processes. Various…”
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Crystal Structure of Human Vascular Endothelial Growth Factor-B: Identification of Amino Acids Important for Receptor Binding by Iyer, Shalini, Scotney, Pierre D., Nash, Andrew D., Ravi Acharya, K.

“…The development of blood vessels (angiogenesis) is critical throughout embryogenesis and in some normal postnatal physiological processes. Pathological…”
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Crystal Structure of Vascular Endothelial Growth Factor-B in Complex with a Neutralising Antibody Fab Fragment by Leonard, Philip, Scotney, Pierre D., Jabeen, Talat, Iyer, Shalini, Fabri, Louis J., Nash, Andrew D., Acharya, K. Ravi

“…Vascular endothelial growth factor (VEGF) B effects blood vessel formation by binding to VEGF receptor 1. To study the specifics of the biological profile of…”
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Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362 by Broughton, Sophie E., Hercus, Timothy R., Nero, Tracy L., Dhagat, Urmi, Owczarek, Catherine M., Hardy, Matthew P., Fabri, Louis J., Scotney, Pierre D., Nash, Andrew D., Wilson, Nicholas J., Lopez, Angel F., Parker, Michael W.

“…Interleukin‐3 (IL‐3) is a member of the beta common family of cytokines that regulate multiple functions of myeloid cells. The IL‐3 receptor‐specific alpha…”
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Towards a Structure-Function Relationship for Vascular Endothelial Growth Factor-B (VEGF-B) by Scrofani, Sergio D.B, Nash, Andrew D

“…The vascular endothelial growth factor (VEGF), or VEGF-A, is intimately involved in both physiological and pathological forms of angiogenesis. VEGF-A is now…”
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